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Professor Steve Ley CBE FRS FMedSci

Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)

Publications

Rapid Continuous Ru-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines
R Labes, D González-Calderón, C Battilocchio, C Mateos, GR Cumming, O de Frutos, JA Rincón, SV Ley
– Synlett
(2017)
28,
Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols
R Labes, C Battilocchio, C Mateos, GR Cumming, O De Frutos, JA Rincón, K Binder, SV Ley
– Organic Process Research and Development
(2017)
21,
1419
Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids
C Bomio, MA Kabeshov, AR Lit, SH Lau, J Ehlert, C Battilocchio, SV Ley
– Chem. Sci.
(2017)
8,
6071
Flow synthesis of cyclobutanones \textit{via} [2 + 2] cycloaddition of keteneiminium salts and ethylene gas
C Battilocchio, G Iannucci, S Wang, E Godineau, A Krieger, MA De, SV Ley
– Reaction Chemistry & Engineering
(2017)
2,
295
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
SS Mohapatra, ZE Wilson, S Roy, SV Ley
– Tetrahedron
(2017)
73,
1812
One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N -Tosylhydrazones: Access to 1,2,4-Triazines
L Crespin, L Biancalana, T Morack, DC Blakemore, SV Ley
– Organic Letters
(2017)
19,
1084
Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor
C Battilocchio, SH Lau, JM Hawkins, SV Ley
– Organic Syntheses
(2017)
94,
34
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie
(2017)
129,
1890
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley
– Angewandte Chemie International Edition (English)
(2017)
56,
1864
On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2- a ]quinazolin-5(1 H)-ones
CL Sutherell, SV Ley
– Synthesis (Germany)
(2016)
49,
135
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk