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Department of Chemistry

 
Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)

Publications

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines
R Grainger, TD Heightman, SV Ley, F Lima, CN Johnson
– Chem Sci
(2019)
10,
2264
Direct Oxidation of Csp3 -H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow.
M Lesieur, C Battilocchio, R Labes, J Jacq, C Genicot, SV Ley, P Pasau
– Chemistry
(2018)
25,
1203
Fast Continuous Alcohol Amination Employing a Hydrogen Borrowing Protocol
R Labes, C Mateos, C Battilocchio, Y Chen, P Dingwall, GR Cumming, JA Rincón, MJ Nieves-Remacha, SV Ley
– Green Chemistry
(2019)
21,
59
Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow
Y Chen, M Leonardi, P Dingwall, R Labes, P Pasau, DC Blakemore, S Ley
– The Journal of Organic Chemistry
(2018)
83,
15558
Across-the-world automated optimization and continuous flow synthesis of pharmaceutical agents operating through a cloud-based server
DE Fitzpatrick, T Maujean, AC Evans, SV Ley
– Angewandte Chemie - International Edition
(2018)
57,
15128
Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor.
Y Chen, DC Blakemore, P Pasau, SV Ley
– Org Lett
(2018)
20,
6569
Integrated plug flow synthesis and crystallisation of pyrazinamide
C Daniel Scott, R Labes, M Depardieu, C Battilocchio, MG Davidson, SV Ley, CC Wilson, K Robertson
– Reaction Chemistry and Engineering
(2018)
3,
631
In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system
DE Fitzpatrick, RJ Mutton, SV Ley
– Reaction Chemistry & Engineering
(2018)
3,
799
Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone
M O'Brien, A Weber, G Hardy, SV Ley
– Tetrahedron
(2018)
74,
5319
A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles
E Godineau, C Battilocchio, M Lehmann, SV Ley, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, AC O'Sullivan
– Organic Process Research & Development
(2018)
22,
955
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk