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Department of Chemistry

 
Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

A practical method for continuous production of sp3-rich compounds from (hetero)aryl halides and redox-active esters.
Y Chen, E Watanabe, O May, SV Ley
– Chemistry
(2019)
chem.201905048
Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source
P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
– The Journal of organic chemistry
(2019)
84,
14394
A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow.
Y Chen, O May, DC Blakemore, SV Ley
– Organic Letters
(2019)
21,
6140
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.
R Grainger, TD Heightman, SV Ley, F Lima, CN Johnson
– Chem Sci
(2019)
10,
2264
Direct Oxidation of Csp(3)-H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow
M Lesieur, C Battilocchio, R Labes, J Jacq, C Genicot, SV Ley, P Pasau
– Chemistry – A European Journal
(2019)
25,
1203
A New World for Chemical Synthesis?
SV Ley, Y Chen, DE Fitzpatrick, O May
– CHIMIA International Journal for Chemistry
(2019)
73,
792
Fast continuous alcohol amination employing a hydrogen borrowing protocol
R Labes, C Mateos, C Battilocchio, Y Chen, P Dingwall, GR Cumming, JA Rincón, MJ Nieves-Remacha, SV Ley
– Green Chemistry
(2019)
21,
59
Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow
Y Chen, M Leonardi, P Dingwall, R Labes, P Pasau, DC Blakemore, SV Ley
– J Org Chem
(2018)
83,
15558
Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.
DE Fitzpatrick, T Maujean, AC Evans, SV Ley
– Angewandte Chemie - International Edition
(2018)
57,
15128
Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server
DE Fitzpatrick, T Maujean, AC Evans, SV Ley
– Angewandte Chemie
(2018)
130,
15348
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk