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Yusuf Hamied Department of Chemistry


Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.


Nitro-Sulfinate Reductive Coupling to Access (Hetero)aryl Sufonamides
SE Gatarz, OM Griffiths, HA Esteves, W Jiao, P Morse, EL Fisher, DC Blakemore, SV Ley
– The Journal of organic chemistry
Photoredox‐Catalyzed Preparation of Sulfones Using Bis‐Piperidine Sulfur Dioxide – An Underutilized Reagent for SO2 Transfer
OM Griffiths, HA Esteves, DC Emmet, SV Ley
– Chemistry - A European Journal
Automated multistep synthesis of 2-pyrazolines in continuous flow
SV Ley, R Labes, JC Pastre, RJ Ingham, C Battilocchio, HM Marçon, MCFCB Damião, DN Tran
– Reaction Chemistry & Engineering
The Evolution of Flow Chemistry: An Opinion on Factors Driving Innovation
SL Bourne, F Amann, SV Ley
– CHIMIA International Journal for Chemistry
Exploring the chemical space of phenyl sulfide oxidation by automated optimization
P Mueller, A Vriza, AD Clayton, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne
– Reaction Chemistry & Engineering
Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis.
OM Griffiths, SV Ley
– Journal of Organic Chemistry
Automated multi-objective reaction optimisation: which algorithm should I use?
P Müller, AD Clayton, J Manson, S Riley, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne
– Reaction Chemistry & Engineering
Flow chemistry - Fundamentals: Second edition
F Darvas, G Dormán, V Hessel, SV Ley
Outlook, future directions, and emerging applications
SV Ley, OS May, OM Griffiths, K Sowa
Flow Chemistry – Applications
F Darvas, G Dormán, V Hessel, SV Ley
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01223 336398

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