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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Exploring the chemical space of phenyl sulfide oxidation by automated optimization
P Mueller, A Vriza, AD Clayton, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne
– Reaction Chemistry & Engineering
(2023)
8,
538
(DOI: 10.1039/d2re00552b)
Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis.
OM Griffiths, SV Ley
– Journal of Organic Chemistry
(2022)
87,
13204
(DOI: 10.1021/acs.joc.2c01684)
Automated multi-objective reaction optimisation: which algorithm should I use?
P Müller, AD Clayton, J Manson, S Riley, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne
– Reaction Chemistry & Engineering
(2022)
7,
987
(DOI: 10.1039/d1re00549a)
Photoredox-Catalyzed Dehydrogenative Csp3-Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow.
OM Griffiths, HA Esteves, Y Chen, K Sowa, OS May, P Morse, DC Blakemore, SV Ley
– J Org Chem
(2021)
86,
13559
(DOI: 10.1021/acs.joc.1c01621)
Enzymatic pretreatment of recycled grease trap waste in batch and continuous-flow reactors for biodiesel production
NN Tran, ME Gelonch, S Liang, Z Xiao, MM Sarafraz, M Tišma, HJ Federsel, SV Ley, V Hessel
– Chemical Engineering Journal
(2021)
426,
131703
(DOI: 10.1016/j.cej.2021.131703)
Formation and utility of reactive ketene intermediates under continuous flow conditions
HR Smallman, JA Leitch, T McBride, SV Ley, DL Browne
– Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
(2021)
93,
132305
(DOI: 10.1016/j.tet.2021.132305)
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells.
S Roy, J Sipthorp, B Mahata, J Pramanik, ML Hennrich, A-C Gavin, SV Ley, SA Teichmann
– iScience
(2021)
24,
102485
(DOI: 10.1016/j.isci.2021.102485)
A Comment on Continuous Flow Technologies within the Agrochemical Industry
SV Ley, Y Chen, A Robinson, B Otter, E Godineau, C Battilocchio
– Organic Process Research and Development
(2021)
25,
713
(DOI: 10.1021/acs.oprd.0c00534)
Living with our machines: Towards a more sustainable future
SV Ley, Y Chen, DE Fitzpatrick, OS May
– Current Opinion in Green and Sustainable Chemistry
(2020)
25,
100353
(DOI: 10.1016/j.cogsc.2020.100353)
Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin.
J Pastre, P Murray, D Browne, G Brancaglion, R Galaverna, R Pilli, SV Ley
– ACS Omega
(2020)
5,
18472
(DOI: 10.1021/acsomega.0c02390)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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    About the University

    Research at Cambridge