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Yusuf Hamied Department of Chemistry

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In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.


CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells.
S Roy, J Sipthorp, B Mahata, J Pramanik, ML Hennrich, A-C Gavin, SV Ley, SA Teichmann
– iScience
A Comment on Continuous Flow Technologies within the Agrochemical Industry
SV Ley, Y Chen, A Robinson, B Otter, E Godineau, C Battilocchio
– Organic Process Research & Development
Formation and utility of reactive ketene intermediates under continuous flow conditions
HR Smallman, JA Leitch, T McBride, SV Ley, DL Browne
– Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
Living with our machines: Towards a more sustainable future
SV Ley, Y Chen, DE Fitzpatrick, OS May
– Current Opinion in Green and Sustainable Chemistry
Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin
J Pastre, P Murray, D Browne, G Brancaglion, R Galaverna, R Pilli, SV Ley
– ACS Omega
In silico rationalisation of selectivity and reactivity in Pd-catalysed C-H activation reactions.
L Cao, M Kabeshov, SV Ley, AA Lapkin
– Beilstein J Org Chem
Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins.
SV Ley, Y Chen, N McNamara, O May, T Pillaiyara, D Blakemore
– Organic Letters
A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions
DE Fitzpatrick, M O'Brien, SV Ley
– Reaction Chemistry and Engineering
A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters
E Watanabe, Y Chen, O May, SV Ley
– Chemistry: A European Journal
Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source
P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
– J Org Chem
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01223 336398

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