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Department of Chemistry

 
Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Living with our machines: Towards a more sustainable future
SV Ley, Y Chen, DE Fitzpatrick, OS May
– Current Opinion in Green and Sustainable Chemistry
(2020)
25,
100353
Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin
JC Pastre, PRD Murray, DL Browne, GA Brancaglion, RS Galaverna, RA Pilli, SV Ley
– ACS omega
(2020)
5,
18472
Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins
Y Chen, N McNamara, O May, T Pillaiyar, DC Blakemore, SV Ley
– Org Lett
(2020)
22,
5746
In silico rationalisation of selectivity and reactivity in Pd-catalysed C-H activation reactions.
L Cao, M Kabeshov, SV Ley, AA Lapkin
– Beilstein J Org Chem
(2020)
16,
1465
A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions
DE Fitzpatrick, M O'Brien, SV Ley
– Reaction Chemistry and Engineering
(2020)
5,
201
A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.
E Watanabe, Y Chen, O May, SV Ley
– Chemistry – A European Journal
(2020)
26,
186
Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source
P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
– Journal of Organic Chemistry
(2019)
84,
14394
A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow
Y Chen, O May, DC Blakemore, SV Ley
– Org Lett
(2019)
21,
6140
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.
R Grainger, TD Heightman, SV Ley, F Lima, CN Johnson
– Chemical Science
(2019)
10,
2264
Direct Oxidation of Csp(3)-H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow
M Lesieur, C Battilocchio, R Labes, J Jacq, C Genicot, SV Ley, P Pasau
– Chemistry - A European Journal
(2018)
25,
1203
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk