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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Nitro-Sulfinate Reductive Coupling to Access (Hetero)aryl Sufonamides
SE Gatarz, OM Griffiths, HA Esteves, W Jiao, P Morse, EL Fisher, DC Blakemore, SV Ley
– J Org Chem
(2024)
89,
1898
Photoredox-Catalyzed Preparation of Sulfones Using Bis-Piperidine Sulfur Dioxide - An Underutilized Reagent for SO2 Transfer.
OM Griffiths, HA Esteves, DC Emmet, SV Ley
– Chemistry
(2023)
e202303976
Automated multistep synthesis of 2-pyrazolines in continuous flow
SV Ley, R Labes, JC Pastre, RJ Ingham, C Battilocchio, HM Marçon, MCFCB Damião, DN Tran
– Reaction Chemistry & Engineering
(2023)
The Evolution of Flow Chemistry: An Opinion on Factors Driving Innovation.
SL Bourne, F Amann, SV Ley
– Chimia (Aarau)
(2023)
77,
288
Exploring the chemical space of phenyl sulfide oxidation by automated optimization
P Mueller, A Vriza, AD Clayton, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne
– Reaction Chemistry & Engineering
(2023)
8,
538
Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis
OM Griffiths, SV Ley
– Journal of Organic Chemistry
(2022)
87,
13204
Automated multi-objective reaction optimisation: which algorithm should I use?
P Müller, AD Clayton, J Manson, S Riley, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne
– Reaction Chemistry and Engineering
(2022)
7,
987
Outlook, future directions, and emerging applications
SV Ley, OS May, OM Griffiths, K Sowa
(2021)
313
Flow Chemistry – Fundamentals
F Darvas, G Dormán, V Hessel, SV Ley
(2021)
1,
1
Flow Chemistry: Volume 2: Applications
F Darvas, G Dormán, V Hessel, SV Ley
(2021)
1
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk