Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Fast Continuous Alcohol Amination Employing a Hydrogen Borrowing Protocol
– Green Chemistry
(2019)
21,
59
(doi: 10.1039/C8GC03328E)
Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow.
– The Journal of Organic Chemistry
(2018)
83,
15558
(doi: 10.1021/acs.joc.8b02721)
Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server
– Angewandte Chemie
(2018)
130,
15348
(doi: 10.1002/ange.201809080)
Across-the-world automated optimization and continuous flow synthesis of pharmaceutical agents operating through a cloud-based server
– Angewandte Chemie International Edition
(2018)
57,
15128
(doi: 10.1002/anie.201809080)
Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor.
– Organic Letters
(2018)
20,
6569
(doi: 10.1021/acs.orglett.8b02907)
In- line separation of multicomponent reaction mixtures using a new semi- continuous supercritical fluid chromatography system
– Reaction Chemistry and Engineering
(2018)
3,
799
(doi: 10.1039/c8re00107c)
Integrated plug flow synthesis and crystallisation of pyrazinamide
– Reaction Chemistry and Engineering
(2018)
3,
631
(doi: 10.1039/C8RE00087E)
Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone
– Tetrahedron
(2018)
74,
5319
(doi: 10.1016/j.tet.2018.06.041)
A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles
– OPRD
(2018)
(doi: 10.1021/acs/oprd.8b00095)
A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles
– Organic Process Research & Development
(2018)
22,
955
(doi: 10.1021/acs.oprd.8b00095)
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