Professor Steve Ley CBE FRS FMedSci | Page 4 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow.

Y Chen, O May, DC Blakemore, SV Ley

– Organic letters

(2019)

21,

6140

(doi: 10.1021/acs.orglett.9b02307)

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines

R Grainger, TD Heightman, SV Ley, F Lima, CN Johnson

– Chem Sci

(2019)

10,

2264

(doi: 10.1039/C8SC04789H)

Direct Oxidation of Csp³−H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow

M Lesieur, C Battilocchio, R Labes, J Jacq, C Genicot, SV Ley, P Pasau

– Chemistry – A European Journal

(2019)

25,

1203

(doi: 10.1002/chem.201805657)

Fast Continuous Alcohol Amination Employing a Hydrogen Borrowing Protocol

R Labes, C Mateos, C Battilocchio, Y Chen, P Dingwall, GR Cumming, JA Rincón, MJ Nieves-Remacha, SV Ley

– Green Chemistry

(2019)

21,

59

(doi: 10.1039/c8gc03328e)

Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow

Y Chen, M Leonardi, P Dingwall, R Labes, P Pasau, DC Blakemore, SV Ley

– J Org Chem

(2018)

83,

15558

(doi: 10.1021/acs.joc.8b02721)

Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server

DE Fitzpatrick, T Maujean, AC Evans, SV Ley

– Angewandte Chemie

(2018)

130,

15348

(doi: 10.1002/ange.201809080)

Across-the-world automated optimization and continuous flow synthesis of pharmaceutical agents operating through a cloud-based server

DE Fitzpatrick, T Maujean, AC Evans, SV Ley

– Angewandte Chemie International Edition

(2018)

57,

15128

(doi: 10.1002/anie.201809080)

Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor.

Y Chen, D Blakemore, P Pasau, S Ley

– Org Lett

(2018)

20,

6569

(doi: 10.1021/acs.orglett.8b02907)

In- line separation of multicomponent reaction mixtures using a new semi- continuous supercritical fluid chromatography system

DE Fitzpatrick, RJ Mutton, SV Ley

– Reaction Chemistry and Engineering

(2018)

3,

799

(doi: 10.1039/c8re00107c)

Integrated plug flow synthesis and crystallisation of pyrazinamide

CD Scott, R Labes, MJ Depardieu, C Battilocchio, MG Davidson, SV Ley, CC Wilson, K Robertson

– Reaction Chemistry and Engineering

(2018)

3,

631

(doi: 10.1039/C8RE00087E)