Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server
Angewandte Chemie
(2018)
130
15348
(doi: 10.1002/ange.201809080)
Three-component assembly of multiply-substituted homoallylic alcohols and amines using a flow chemistry photoreactor
Org Lett
(2018)
20
6569
(doi: 10.1021/acs.orglett.8b02907)
Integrated plug flow synthesis and crystallisation of pyrazinamide
Reaction Chemistry & Engineering
(2018)
3
631
(doi: 10.1039/C8RE00087E)
In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system
Reaction Chemistry & Engineering
(2018)
3
799
(doi: 10.1039/c8re00107c)
Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone
Tetrahedron
(2018)
74
5319
(doi: 10.1016/j.tet.2018.06.041)
Award Address (Arthur C. Cope Award sponsored by the Arthur C. Cope Fund). Natural product synthesis as an inspiration for discovery
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles
OPRD
(2018)
(doi: 10.1021/acs/oprd.8b00095)
A Convergent Continuous Multistep Process for the Preparation of C4‑Oxime-Substituted Thiazoles
Organic Process Research & Development
(2018)
22
955
(doi: 10.1021/acs.oprd.8b00095)
Engineering chemistry for the future of organic synthesis
Tetrahedron
(2018)
74
3085
(doi: 10.1016/j.tet.2018.05.046)
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