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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone
SV Ley, M O'Brien
– Tetrahedron
(2018)
74,
5319
(doi: 10.1016/j.tet.2018.06.041)
A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles
SV Ley, E Godineau, C Battilocchio, M Lehmann, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, AC O'Sullivan
– OPRD
(2018)
(doi: 10.1021/acs/oprd.8b00095)
A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles
E Godineau, C Battilocchio, M Lehmann, SV Ley, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, ACC O'sullivan
– Organic Process Research & Development
(2018)
22,
955
(doi: 10.1021/acs.oprd.8b00095)
Engineering chemistry for the future of organic synthesis Preface
SV Ley
– Tetrahedron
(2018)
74,
3085
(doi: 10.1016/j.tet.2018.05.046)
Professor Steven V Ley CBE FRS FMedSci
SV Ley
– Tetrahedron
(2018)
74,
3086
(doi: 10.1016/j.tet.2018.05.047)
Continuous flow hydration of pyrazine-2-carbonitrile in a manganese dioxide column reactor
C Battilocchio, SH Lau, JM Hawkins, SV Ley
– Organic Syntheses
(2018)
94,
34
(doi: 10.1002/0471264229.os094.03)
Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.
DJ Ritson, C Battilocchio, SV Ley, JD Sutherland
– Nature Communications
(2018)
9,
1821
(doi: 10.1038/s41467-018-04147-2)
The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony
SV Ley
– Angewandte Chemie International Edition
(2018)
57,
5182
(doi: 10.1002/anie.201802383)
Editorial: Harmonische Zusammenarbeit von Mensch und Maschine in der chemischen Synthese
SV Ley
– Angewandte Chemie
(2018)
130,
5278
(doi: 10.1002/ange.201802383)
Diastereoselective Synthesis of Functionalized Indolines Using in situ Generated Allyl Boronic Species
JA Forni, SH Lau, JS Poh, C Battilocchio, SV Ley, JC Pastre
– Synlett
(2018)
29,
825
(doi: 10.1055/s-0036-1589164)
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Research Group

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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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