Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

In- line separation of multicomponent reaction mixtures using a new semi- continuous supercritical fluid chromatography system

DE Fitzpatrick, RJ Mutton, SV Ley

Reaction Chemistry & Engineering

(2018)

799

(doi: 10.1039/c8re00107c)

Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone

SV Ley, M O'Brien

Tetrahedron

(2018)

5319

(doi: 10.1016/j.tet.2018.06.041)

A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles

SV Ley, E Godineau, C Battilocchio, M Lehmann, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, AC O'Sullivan

OPRD

(2018)

(doi: 10.1021/acs/oprd.8b00095)

A Convergent Continuous Multistep Process for the Preparation of C₄-Oxime-Substituted Thiazoles

E Godineau, C Battilocchio, M Lehmann, SV Ley, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, ACC O'sullivan

Organic Process Research & Development

(2018)

955

(doi: 10.1021/acs.oprd.8b00095)