Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Editorial: Harmonische Zusammenarbeit von Mensch und Maschine in der chemischen Synthese
Angewandte Chemie
(2018)
130
5278
(doi: 10.1002/ange.201802383)
Diastereoselective Synthesis of Functionalized Indolines Using in situ Generated Allyl Boronic Species
Synlett
(2018)
29
825
(doi: 10.1055/s-0036-1589164)
Rapid, selective and stable HaloTag-Lb ADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides
Reaction Chemistry & Engineering
(2018)
3
8
(doi: 10.1039/c7re00173h)
Award Address (Arthur C. Cope Award sponsored by the Arthur C. Cope Fund). Natural product synthesis as an inspiration for discovery
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow
Chem Commun (Camb)
(2018)
54
5606
(doi: 10.1039/c8cc02169d)
C-H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow.
Chemical communications (Cambridge, England)
(2018)
54
11685
(doi: 10.1039/c8cc06202a)
Real-time spectroscopic analysis enabling quantitative and safe consumption of fluoroform during nucleophilic trifluoromethylation in flow.
ACS Sustainable Chemistry and Engineering
(2018)
6
1489
Preparation of homoallylic amines via a three-component coupling process
Organic and Biomolecular Chemistry
(2018)
16
6652
(doi: 10.1039/c8ob01831f)
Engineering Chemistry to Enable Bioactive Small Molecule Discovery
(2018)
10
184
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