Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Rapid, selective and stable HaloTag- Lb ADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides
– Reaction Chemistry & Engineering
(2018)
3,
8
(doi: 10.1039/c7re00173h)
Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow
– Chem Commun (Camb)
(2018)
54,
5606
(doi: 10.1039/c8cc02169d)
Real-time spectroscopic analysis enabling quantitative and safe consumption of fluoroform during nucleophilic trifluoromethylation in flow.
– ACS Sustainable Chemistry & Engineering
(2018)
6,
1489
Preparation of homoallylic amines via a three-component coupling process
– Organic & Biomolecular Chemistry
(2018)
16,
6652
(doi: 10.1039/C8OB01831F)
Engineering Chemistry to Enable Bioactive Small Molecule Discovery
(2018)
10,
184
C-H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow.
– Chemical communications (Cambridge, England)
(2018)
54,
11685
(doi: 10.1039/c8cc06202a)
A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions
– Angewandte Chemie
(2017)
129,
16829
(doi: 10.1002/ange.201710445)
Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N‑Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives
– Journal of Organic Chemistry
(2017)
82,
13093
(doi: 10.1021/acs.joc.7b02146)
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