Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters
– Angewandte Chemie - International Edition
(2017)
56,
15136
(doi: 10.1002/anie.201709690)
A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions.
– Angew Chem Int Ed Engl
(2017)
56,
16602
(doi: 10.1002/anie.201710445)
Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3‑Bromoisoxazolines
– Organic Process Research & Development
(2017)
21,
1588
(doi: 10.1021/acs.oprd.7b00229)
Rapid Continuous Ru-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines
– Synlett
(2017)
28,
2855
(doi: 10.1055/s-0036-1589096)
Chemoselective Continuous Ru-Catalyzed Hydrogen-transfer Oppenauer-type Oxidation of Secondary Alcohols
– Organic Process Research & Development
(2017)
21,
1419
(doi: 10.1021/acs.oprd.7b00190)
Unveiling the role of boroxines in metal-free carbon–carbon homologations using diazo compounds and boronic acids
– Chemical science
(2017)
8,
6071
(doi: 10.1039/c7sc02264f)
Flow synthesis of cyclobutanones $\textit{via}$ [2 + 2] cycloaddition of keteneiminium salts and ethylene gas
– Reaction Chemistry & Engineering
(2017)
2,
295
(doi: 10.1039/C7RE00020K)
A New Methodology for Incorporating Chiral Linkers into Stapled Peptides
– Chembiochem : a European journal of chemical biology
(2017)
18,
1066
(doi: 10.1002/cbic.201700075)
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
– Tetrahedron
(2017)
73,
1812
(doi: 10.1016/j.tet.2017.02.026)
One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N-Tosylhydrazones: Access to 1,2,4-Triazines.
– Organic Letters
(2017)
19,
1084
(doi: 10.1021/acs.orglett.7b00101)
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