Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow‐Generated Diazo Compounds and Propargylated Amines
– Angewandte Chemie
(2017)
129,
1890
(doi: 10.1002/ange.201611067)
Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines
– Angewandte Chemie International Edition
(2017)
56,
1864
(doi: 10.1002/anie.201611067)
On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2- a ]quinazolin-5(1 H)-ones
– Synthesis (Germany)
(2017)
49,
135
(doi: 10.1055/s-0035-1562792)
Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides
– Reaction Chemistry and Engineering
(2017)
2,
822
(doi: 10.1039/c7re00164a)
Engineering chemistry for the future of chemical synthesis
– Tetrahedron
(2017)
74,
3087
(doi: 10.1016/j.tet.2017.08.050)
Engineering chemistry: Integrating batch and flow reactions on a single, automated reactor platform
– Reaction Chemistry and Engineering
(2016)
1,
629
(doi: 10.1039/c6re00160b)
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp$^2$)-C(sp$^3$) Cross-Couplings in Flow
– Angewandte Chemie International Edition
(2016)
55,
14291
(doi: 10.1002/anie.201605548)
Combination of Enabling Technologies to Improve and Describe the Stereoselectivity of Wolff–Staudinger Cascade Reaction
– Synthesis
(2016)
48,
3515
(doi: 10.1055/s-0035-1562579)
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
– Sci Adv
(2016)
2,
e1600760
(doi: 10.1126/sciadv.1600760)
Continuous Processing and Efficient $\textit{in Situ}$ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy
– Organic Process Research & Development
(2016)
20,
1603
(doi: 10.1021/acs.oprd.6b00177)
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