Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Unveiling the role of boroxines in metal-free carbon–carbon homologations using diazo compounds and boronic acids

C Bomio-Confaglia, Ley, Kabeshov, Battilocchio, lau, lit, ehlert

Chem Sci

(2017)

8

6071

(doi: 10.1039/C7SC02264F)

Flow synthesis of cyclobutanones $\textit{via}$ [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

C Battilocchio, G Iannucci, S Wang, E Godineau, A Krieger, A De Mesmaeker, SV Ley

Reaction Chemistry & Engineering

(2017)

2

295

(doi: 10.1039/C7RE00020K)

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides

JC Serrano, J Sipthorp, W Xu, LS Itzhaki, SV Ley

Chembiochem

(2017)

18

1066

(doi: 10.1002/cbic.201700075)

Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes

SS Mohapatra, ZE Wilson, S Roy, SV Ley

Tetrahedron

(2017)

73

1812

(doi: 10.1016/j.tet.2017.02.026)

One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N-Tosylhydrazones: Access to 1,2,4-Triazines.

L Crespin, L Biancalana, T Morack, DC Blakemore, SV Ley

Organic letters

(2017)

19

1084

(doi: 10.1021/acs.orglett.7b00101)

Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines

J-S Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley

Angewandte Chemie International Edition (English)

(2017)

56

1864

(doi: 10.1002/anie.201611067)

Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines

J Poh, S Makai, T von Keutz, DN Tran, C Battilocchio, P Pasau, SV Ley

Angewandte Chemie

(2017)

129

1890

(doi: 10.1002/ange.201611067)

On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2- a ]quinazolin-5(1 H)-ones

C Sutherell, S Ley

Synthesis Germany

(2017)

49

135

(doi: 10.1055/s-0035-1562792)

Engineering chemistry for the future of chemical synthesis

DE Fitzpatrick, SV Ley

Tetrahedron

(2017)

74

3087

(doi: 10.1016/j.tet.2017.08.050)

Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides

MA Kabeshov, B Musio, SV Ley

Reaction Chemistry & Engineering

(2017)

2

822

(doi: 10.1039/c7re00164a)