Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Combination of Enabling Technologies to Improve and Describe the Stereoselectivity of Wolff–Staudinger Cascade Reaction

B Musio, F Mariani, EP Śliwiński, MA Kabeshov, H Odajima, SV Ley

Synthesis Germany

(2016)

3515

(doi: 10.1055/s-0035-1562579)

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia

S Picaud, K Leonards, J-P Lambert, O Dovey, C Wells, O Fedorov, O Monteiro, T Fujisawa, C-Y Wang, H Lingard, C Tallant, N Nikbin, L Guetzoyan, R Ingham, SV Ley, P Brennan, S Muller, A Samsonova, A-C Gingras, J Schwaller, G Vassiliou, S Knapp, P Filippakopoulos

Science Advances

(2016)

e1600760

(doi: 10.1126/sciadv.1600760)

Continuous Processing and Efficient $\textit{in Situ}$ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy

B Ahmed-Omer, E Sliwinski, JP Cerroti, SV Ley

Organic Process Research & Development

(2016)

1603

(doi: 10.1021/acs.oprd.6b00177)

The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B

S Fenner, ZE Wilson, SV Ley

Chemistry - A European Journal

(2016)

15902

(doi: 10.1002/chem.201603157)

Flow Chemistry in Europe

V Hessel, SV Ley

Journal of Flow Chemistry

(2016)

135

(doi: 10.1556/1846.2016.22222)

Taming hazardous chemistry by continuous flow technology

M Movsisyan, EIP Delbeke, JKET Berton, C Battilocchio, SV Ley, CV Stevens

Chemical Society reviews

(2016)

4892

(doi: 10.1039/c5cs00902b)

A multicomponent approach for the preparation of homoallylic alcohols.

J-S Poh, S-H Lau, IG Dykes, DN Tran, C Battilocchio, SV Ley

Chem Sci

(2016)

6803

(doi: 10.1039/c6sc02581a)

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.

J-S Poh, C García-Ruiz, A Zúñiga, F Meroni, DC Blakemore, DL Browne, SV Ley

Organic and Biomolecular Chemistry

(2016)

5983

(doi: 10.1039/c6ob00970k)

Identification and Development of 2,3-Dihydropyrrolo[1,2‑a]quinazolin-5(1H)‑one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

CL Sutherell, C Tallant, OP Monteiro, C Yapp, JE Fuchs, O Fedorov, P Siejka, S Müller, S Knapp, JD Brenton, PE Brennan, SV Ley

J Med Chem

(2016)

5095

(doi: 10.1021/acs.jmedchem.5b01997)

Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification

T Ouchi, RJ Mutton, V Rojas, DE Fitzpatrick, DG Cork, C Battilocchio, SV Ley

ACS Sustainable Chemistry and Engineering

(2016)

1912

(doi: 10.1021/acssuschemeng.6b00287)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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