Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation

J-S Poh, C García-Ruiz, A Zúñiga, F Meroni, DC Blakemore, DL Browne, SV Ley

Organic & biomolecular chemistry

(2016)

14

5983

(doi: 10.1039/c6ob00970k)

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.

CL Sutherell, C Tallant, OP Monteiro, C Yapp, JE Fuchs, O Fedorov, P Siejka, S Müller, S Knapp, JD Brenton, PE Brennan, SV Ley

J Med Chem

(2016)

59

5095

(doi: 10.1021/acs.jmedchem.5b01997)

Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification

T Ouchi, RJ Mutton, V Rojas, DE Fitzpatrick, DG Cork, C Battilocchio, SV Ley

ACS Sustainable Chemistry and Engineering

(2016)

4

1912

(doi: 10.1021/acssuschemeng.6b00287)

Development of the industrial synthesis of vitamin A

GL Parker, LK Smith, IR Baxendale

Tetrahedron

(2016)

72

1645

(doi: 10.1016/j.tet.2016.02.029)

The Generation of a Library of Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis

P Filipponi, IR Baxendale

European Journal of Organic Chemistry

(2016)

2016

2000

(doi: 10.1002/ejoc.201600222)

Enabling technologies for the future of chemical synthesis

DE Fitzpatrick, C Battilocchio, SV Ley

ACS Cent Sci

(2016)

2

131

(doi: 10.1021/acscentsci.6b00015)

Iterative reactions of transient boronic acids enable sequential C-C bond formation

C Battilocchio, F Feist, A Hafner, M Simon, DN Tran, DM Allwood, DC Blakemore, SV Ley

Nat Chem

(2016)

8

360

(doi: 10.1038/nchem.2439)

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.

D Lücke, T Dalton, SV Ley, ZE Wilson

Chemistry A European Journal

(2016)

22

4206

(doi: 10.1002/chem.201504457)

A multistep continuous flow synthesis machine for the preparation of pyrazoles

J-S Poh, DL Browne, SV Ley

React Chem Eng

(2016)

1

101

(doi: 10.1039/c5re00082c)

Continuous photochemistry: The flow synthesis of ibuprofen: Via a photo-Favorskii rearrangement

M Baumann, IR Baxendale

Reaction Chemistry and Engineering

(2016)

1

147

(doi: 10.1039/c5re00037h)