Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Editorial - Flow Chemistry and Catalysis

SV Ley

Catalysis Science & Technology

(2016)

6

4676

(doi: 10.1039/c6cy90064j)

Correction: Controlled generation and use of CO in flow

SVF Hansen, ZE Wilson, T Ulven, SV Ley

Reaction Chemistry & Engineering

(2016)

1

340

(doi: 10.1039/c6re90010k)

Welcome to Reaction Chemistry & Engineering

SA Khan, IR Baxendale, JM Hawkins, SV Ley, K Jensen, V Hessel, G Luo, D Blackmond, A Katz, DG Vlachos, ME Davis

Reaction Chemistry & Engineering

(2016)

1

8

(doi: 10.1039/c6re90001a)

Continuous-Flow Synthesis of 2 H -Azirines and Their Diastereoselective Transformation to Aziridines

M Baumann, I Baxendale

Synlett

(2015)

27

159

(doi: 10.1055/s-0035-1560391)

Controlled Flow Precipitation as a Valuable Tool for Synthesis

P Filipponi, A Gioiello, IR Baxendale

Organic Process Research & Development

(2015)

20

371

(doi: 10.1021/acs.oprd.5b00331)

Synthesis of 1,3,6-Trisubstituted Azulenes

TO Leino, M Baumann, J Yli-Kauhaluoma, IR Baxendale, EAA Wallén

Journal of Organic Chemistry

(2015)

80

11513

(doi: 10.1021/acs.joc.5b02271)

A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis

DE Fitzpatrick, C Battilocchio, SV Ley

Organic Process Research & Development

(2015)

20

386

(doi: 10.1021/acs.oprd.5b00313)

Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade

M Baumann, IR Baxendale

Journal of Organic Chemistry

(2015)

80

10806

(doi: 10.1021/acs.joc.5b01982)

Synthesis of a Precursor to Sacubitril Using Enabling Technologies.

S-H Lau, SL Bourne, B Martin, B Schenkel, G Penn, SV Ley

Org Lett

(2015)

17

5436

(doi: 10.1021/acs.orglett.5b02806)

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors (vol 101, pg 573, 2015)

D de Lucia, OM Lucio, B Musio, A Bender, M Listing, S Dennhardt, A Koeberle, U Garscha, R Rizzo, S Manfredini, O Werz, SV Ley

European Journal of Medicinal Chemistry

(2015)

103

223

(doi: 10.1016/j.ejmech.2015.08.050)