Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Continuous photochemistry: The flow synthesis of ibuprofen: Via a photo-Favorskii rearrangement

M Baumann, IR Baxendale

Reaction Chemistry and Engineering

(2016)

1

147

(doi: 10.1039/c5re00037h)

Controlled generation and use of CO in flow

SVF Hansen, ZE Wilson, T Ulven, SV Ley

Reaction Chemistry & Engineering

(2016)

1

280

(doi: 10.1039/c6re00020g)

Welcome to Reaction Chemistry & Engineering

SA Khan, IR Baxendale, JM Hawkins, SV Ley, K Jensen, V Hessel, G Luo, D Blackmond, A Katz, DG Vlachos, ME Davis

Reaction Chemistry & Engineering

(2016)

1

8

(doi: 10.1039/c6re90001a)

Controlled generation and use of CO in flow (vol 1, pg 280, 2016)

SVF Hansen, ZE Wilson, T Ulven, SV Ley

Reaction Chemistry & Engineering

(2016)

1

340

(doi: 10.1039/c6re90010k)

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

N Holmes, GR Akien, RJD Savage, C Stanetty, IR Baxendale, AJ Blacker, BA Taylor, RL Woodward, RE Meadows, RA Bourne

Reaction Chemistry & Engineering

(2016)

1

96

(doi: 10.1039/c5re00083a)

Continuous-Flow Synthesis of 2H-Azirines and Their Diastereoselective Transformation to Aziridines

M Baumann, I Baxendale

Synlett

(2015)

27

159

(doi: 10.1055/s-0035-1560391)

Controlled Flow Precipitation as a Valuable Tool for Synthesis

P Filipponi, A Gioiello, IR Baxendale

Organic Process Research & Development

(2015)

20

371

(doi: 10.1021/acs.oprd.5b00331)

A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis

DE Fitzpatrick, C Battilocchio, SV Ley

Organic Process Research & Development

(2015)

20

386

(doi: 10.1021/acs.oprd.5b00313)

Synthesis of 1,3,6-Trisubstituted Azulenes

TO Leino, M Baumann, J Yli-Kauhaluoma, IR Baxendale, EAA Wallén

J Org Chem

(2015)

80

11513

(doi: 10.1021/acs.joc.5b02271)

Synthesis of a Precursor to Sacubitril Using Enabling Technologies.

S-H Lau, SL Bourne, B Martin, B Schenkel, G Penn, SV Ley

Organic letters

(2015)

17

5436

(doi: 10.1021/acs.orglett.5b02806)