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Yusuf Hamied Department of Chemistry

 

Professor Rosana Collepardo-Guevara

Professor of Computational and Molecular Biophysics

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws
MJ Maristany, A Aguirre Gonzalez, JR Espinosa, J Huertas, R Collepardo-Guevara, JA Joseph
(2025)
(doi: 10.7554/elife.99068.2)
Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly
L Chen, MJ Maristany, SE Farr, J Luo, BA Gibson, LK Doolittle, JR Espinosa, J Huertas, S Redding, R Collepardo-Guevara, MK Rosen
(2024)
(doi: 10.1101/2024.12.23.627571)
Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation
I Sanchez-Burgos, A Tejedor, A Castro, A Feito, R Collepardo-Guevara, J Espinosa
(2024)
(doi: 10.1101/2024.12.16.628676)
Capturing single-molecule properties does not ensure accurate prediction of biomolecular phase diagrams
A Feito, I Sanchez-Burgos, A Rey, R Collepardo-Guevara, JR Espinosa, AR Tejedor
– Molecular Physics
(2024)
122,
e2425757
(doi: 10.1080/00268976.2024.2425757)
Dynamically arrested condensate fusion creates complex structures with varying material properties
N Erkamp, I Sanchez-Burgos, A Zhou, T Krug, S Qamar, T Sneideris, E Zhang, K Nakajima, A Chen, R Collepardo-Guevara, J van Hest, P St George-Hyslop, D Weitz, J Espinosa, T Knowles
(2024)
(doi: 10.1101/2024.11.15.623768)
Capturing single-molecule properties does not ensure accurate prediction of biomolecular phase diagrams
A Feito, I Sanchez-Burgos, A Rey, R Collepardo-Guevara, J Espinosa, A Tejedor
(2024)
(doi: 10.1101/2024.10.24.619983)
Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates
A Feito, I Sanchez-Burgos, I Tejero, E Sanz, A Rey, R Collepardo-Guevara, A Tejedor, J Espinosa
(2024)
(doi: 10.1101/2024.08.28.610132)
Chemically-informed coarse-graining of electrostatic forces in charge-rich biomolecular condensates
A Tejedor, AA Gonzalez, J Maristany, PY Chew, K Russell, J Ramirez, J Espinosa, R Collepardo-Guevara
(2024)
(doi: 10.1101/2024.07.26.605370)
Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws
MJ Maristany, AA Gonzalez, JR Espinosa, J Huertas, R Collepardo-Guevara, JA Joseph
(2024)
(doi: 10.7554/elife.99068.1)
Energy Landscapes and Heat Capacity Signatures for Peptides Correlate with Phase Separation Propensity
Nicy, R Collepardo-Guevara, JA Joseph, DJ Wales
– QRB Discovery
(2023)
4,
e7
(doi: 10.1017/qrd.2023.5)
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Research Interest Group

Email address

rc597@cam.ac.uk

College

Clare College

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