University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry
KK Nakashima, FZ Mihoubi, JS Saraya, KO Russell, F Rahmatova, JD Robinson, MJ Maristany, J Huertas, R Rubio-Sánchez, R Collepardo-Guevara, DK O’Flaherty, C Bonfio
Nature Communications
(2025)
16
Oct4 clusters promote DNA accessibility by enhancing chromatin plasticity
J Huertas, MJ Maristany, R Collepardo-Guevara
(2025)
Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration.
E Pedraza, AR Tejedor, A Feito, F Gámez, R Collepardo-Guevara, E Sanz, JR Espinosa
J Chem Theory Comput
(2025)
21
Charged mutations in the FUS low-complexity domain modulate condensate aging kinetics
E Pedraza, D Hoyos, A Feito, F Gámez, I Sanchez-Burgos, R Collepardo-Guevara, AR Tejedor, JR Espinosa
Cell Reports Physical Science
(2025)
6
An electrostatic repulsion model of centromere organisation
C Bell, L Chen, MJ Maristany, C Blaukopf, H Zhou, J Huertas, JI Perez Lopez, CCH Langer, TL Steinacker, N Schütte, LK Doolittle, JR Espinosa, S Redding, R Collepardo-Guevara, MK Rosen, DW Gerlich
bioRxiv
(2025)
Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation
I Sanchez-Burgos, AR Tejedor, A Castro, A Feito, R Collepardo-Guevara, JR Espinosa
Nat Commun
(2025)
16
Current practices in the study of biomolecular condensates: a community comment.
S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag
Nat Commun
(2025)
16
Nucleosome spacing can fine-tune higher-order chromatin assembly.
L Chen, MJ Maristany, SE Farr, J Luo, BA Gibson, LK Doolittle, JR Espinosa, J Huertas, S Redding, R Collepardo-Guevara, MK Rosen
Nat Commun
(2025)
16
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
M Montez, D Zhu, J Huertas, MJ Maristany, B Rutjens, M Nielsen, R Collepardo-Guevara, C Dean
Nat Commun
(2025)
16
Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration
E Pedraza, AR Tejedor, A Feito, F Gámez, R Collepardo-Guevara, E Sanz, JR Espinosa
(2025)

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