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Yusuf Hamied Department of Chemistry

 

Professor Rosana Collepardo-Guevara

Professor of Computational and Molecular Biophysics

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Time-Dependent Material Properties of Aging Biomolecular Condensates from Different Viscoelasticity Measurements in Molecular Dynamics Simulations.
AR Tejedor, R Collepardo-Guevara, J Ramírez, JR Espinosa
– J Phys Chem B
(2023)
127,
4441
(doi: 10.1021/acs.jpcb.3c01292)
Theoretical and Data-Driven Approaches for Biomolecular Condensates.
KL Saar, D Qian, LL Good, AS Morgunov, R Collepardo-Guevara, RB Best, TPJ Knowles
– Chemical reviews
(2023)
123,
8988
(doi: 10.1021/acs.chemrev.2c00586)
Energy landscapes and heat capacity signatures for peptides correlate with phase separation propensity
Nicy, J Joseph, R Collepardo-Guevara, D Wales
(2023)
(doi: 10.1101/2023.05.05.539523)
Aromatic and arginine content drives multiphasic condensation of protein–RNA mixtures
PY Chew, J Joseph, R Collepardo-Guevara, A Reinhardt
(2023)
(doi: 10.1101/2023.04.05.535720)
Thermodynamic origins of two-component multiphase condensates of proteins
PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt
– Chemical Science
(2023)
14,
2022.04.22.489187
(doi: 10.1039/d2sc05873a)
Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation
K Brown, PY Chew, S Ingersoll, J Espinosa, A Aguirre, T Kutateladze, RC Guevara, X Ren
(2022)
(doi: 10.1101/2022.12.26.521954)
Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates
S Blazquez, I Sanchez-Burgos, J Ramirez, T Higginbotham, M Conde, R Collepardo-Guevara, A Tejedor, J Espinosa
(2022)
(doi: 10.1101/2022.12.14.520383)
Time-dependent material properties of ageing biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations
A Tejedor, R Collepardo-Guevara, J Ramírez, J Espinosa
(2022)
(doi: 10.1101/2022.12.07.519428)
Surfactants or scaffolds? RNAs of different lengths exhibit heterogeneous distributions and play diverse roles in RNA-protein condensates
I Sanchez-Burgos, L Herriott, R Collepardo-Guevara, J Espinosa
(2022)
(doi: 10.1101/2022.11.09.515827)
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it.
AR Tejedor, I Sanchez-Burgos, M Estevez-Espinosa, A Garaizar, R Collepardo-Guevara, J Ramirez, JR Espinosa
– Nat Commun
(2022)
13,
5717
(doi: 10.1038/s41467-022-32874-0)
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