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Yusuf Hamied Department of Chemistry

 

Professor Rosana Collepardo-Guevara

Professor of Computational and Molecular Biophysics

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation
I Sanchez-Burgos, AR Tejedor, A Castro, A Feito, R Collepardo-Guevara, JR Espinosa
– Nature communications
(2025)
16,
8050
(doi: 10.1038/S41467-025-62686-X)
Nucleosome spacing can fine-tune higher-order chromatin assembly
L Chen, MJ Maristany, SE Farr, J Luo, BA Gibson, LK Doolittle, JR Espinosa, J Huertas, S Redding, R Collepardo-Guevara, MK Rosen
– Nat Commun
(2025)
16,
6315
(doi: 10.1038/s41467-025-61482-x)
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
M Montez, D Zhu, J Huertas, MJ Maristany, B Rutjens, M Nielsen, R Collepardo-Guevara, C Dean
– Nature Communications
(2025)
16,
5550
(doi: 10.1038/s41467-025-60735-z)
Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration
E Pedraza, A Tejedor, A Feito, F Gámez, R Collepardo-Guevara, E Sanz, J Espinosa
(2025)
(doi: 10.1101/2025.05.09.653068)
Charged mutations in the FUS low-complexity domain modulate condensate ageing kinetics
E Pedraza, D Hoyos, A Feito, F Gamez, I Sanchez-Burgos, R Collepardo-Guevara, A R. Tejedor, J R. Espinosa
(2025)
(doi: 10.1101/2025.03.26.645197)
Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organisation
L Tamon, Z Fahmi, J Ashford, R Collepardo-Guevara, A Sahakyan
(2025)
(doi: 10.1101/2025.03.16.643527)
Molecular insights on the mechanism of α1-antitrypsin condensate formation and maturation
I Sanchez-Burgos, A Tejedor, R Collepardo-Guevara, JB de la Serna, J Espinosa
(2025)
(doi: 10.1101/2025.03.11.642656)
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells
M Shimazoe, C Phillips, J Huertas, S Ide, S Tamura, S Farr, SS Ashwin, M Sasai, R Collepardo-Guevara, K Maeshima
(2025)
(doi: 10.1101/2025.03.05.641622)
Compositional control of ageing kinetics in TDP-43 condensates
N Espejo, A Feito, I Sanchez-Burgos, A Garaizar, M Conde, A Rey, A Castro, R Collepardo-Guevara, A Tejedor, J Espinosa
(2025)
(doi: 10.1101/2025.02.21.639421)
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
M Montez, D Zhu, J Huertas Martin, MJ Maristany, B Rutjens, M Nielsen, R Collepardo-Guevara, C Dean
(2025)
(doi: 10.1101/2025.02.17.638618)
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Research Interest Group

Email address

rc597@cam.ac.uk

College

Clare College

    Study at Cambridge

    About the University

    Research at Cambridge