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Yusuf Hamied Department of Chemistry

 

University Assistant Professor

Rosana is an Interdisciplinary Associate Professor in the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Dr Collepardo discusses her research

Publications

Aging can transform single-component protein condensates into multiphase architectures.
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
– Proceedings of the National Academy of Sciences
(2022)
119,
e2119800119
Designing multiphase biomolecular condensates by coevolution of protein mixtures
PY Chew, J Joseph, R Collepardo-Guevara, A Reinhardt
– bioRxiv
(2022)
Multiscale modelling of chromatin organisation: Resolving nucleosomes at near-atomistic resolution inside genes
J Huertas, EJ Woods, R Collepardo-Guevara
– Current Opinion in Cell Biology
(2022)
75,
102067
Ageing critically transforms the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
A Tejedor, I Sanchez-Burgos, M Estevez-Espinosa, A Garaizar, R Collepardo-Guevara, J Ramirez, J Espinosa
(2022)
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
A Garaizar, JR Espinosa, JA Joseph, R Collepardo-Guevara
– Scientific reports
(2022)
12,
4390
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
JA Joseph, A Reinhardt, A Aguirre, PY Chew, KO Russell, JR Espinosa, A Garaizar, R Collepardo-Guevara
– Biophysical Journal
(2022)
121,
307A
Study on stability, composition, and protein arrangement within bio-condensates formed via liquid-liquid phase separation
IS Burgos, JR Espinosa, A Garaizar, R Collepardo-Guevara, JA Joseph
– BIOPHYSICAL JOURNAL
(2022)
121,
357A
Comparison of experimental phase diagrams and residue-level coarse-grained simulations of intrinsically disordered proteins
MJ Maristany, R Collepardo-Guevara, JA Joseph, A Reinhardt
– Biophysical Journal
(2022)
121,
471A
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins.
I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara
– PLoS Comput Biol
(2022)
18,
e1009810
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– Nano letters
(2022)
22,
612
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Research Groups

Research Interest Group

Email address

rc597@cam.ac.uk