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Yusuf Hamied Department of Chemistry

 

Professor Rosana Collepardo-Guevara

Professor of Computational and Molecular Biophysics

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Charged mutations in the FUS low-complexity domain modulate condensate ageing kinetics
E Pedraza, D Hoyos, A Feito, F Gamez, I Sanchez-Burgos, R Collepardo-Guevara, A R. Tejedor, J R. Espinosa
(2025)
(doi: 10.1101/2025.03.26.645197)
Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organisation
L Tamon, Z Fahmi, J Ashford, R Collepardo-Guevara, A Sahakyan
(2025)
(doi: 10.1101/2025.03.16.643527)
Molecular insights on the mechanism ofα1-antitrypsin condensate formation and maturation
I Sanchez-Burgos, A Tejedor, R Collepardo-Guevara, JB de la Serna, J Espinosa
(2025)
(doi: 10.1101/2025.03.11.642656)
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells
M Shimazoe, C Phillips, J Huertas, S Ide, S Tamura, S Farr, SS Ashwin, M Sasai, R Collepardo-Guevara, K Maeshima
(2025)
(doi: 10.1101/2025.03.05.641622)
Compositional control of ageing kinetics in TDP-43 condensates
N Espejo, A Feito, I Sanchez-Burgos, A Garaizar, M Conde, A Rey, A Castro, R Collepardo-Guevara, A Tejedor, J Espinosa
(2025)
(doi: 10.1101/2025.02.21.639421)
Cold-induced nucleosome dynamics linked to silencing of ArabidopsisFLC
M Montez, D Zhu, J Huertas Martin, MJ Maristany, B Rutjens, M Nielsen, R Collepardo-Guevara, C Dean
(2025)
(doi: 10.1101/2025.02.17.638618)
Decoding phase separation of prion-like domains through data-driven scaling laws
MJ Maristany, AA Gonzalez, JR Espinosa, J Huertas, R Collepardo-Guevara, JA Joseph
– Elife
(2025)
13,
rp99068
(doi: 10.7554/elife.99068.3)
Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates.
A R Tejedor, A Aguirre Gonzalez, MJ Maristany, PY Chew, K Russell, J Ramirez, JR Espinosa, R Collepardo-Guevara
– ACS central science
(2025)
11,
302
(doi: 10.1021/acscentsci.4c01617)
Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates
A Feito, I Sanchez-Burgos, I Tejero, E Sanz, A Rey, R Collepardo-Guevara, AR Tejedor, JR Espinosa
– PLoS Comput Biol
(2025)
21,
e1012737
(doi: 10.1371/journal.pcbi.1012737)
Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws
MJ Maristany, A Aguirre Gonzalez, JR Espinosa, J Huertas, R Collepardo-Guevara, JA Joseph
(2025)
(doi: 10.7554/elife.99068.2)
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Research Interest Group

Email address

rc597@cam.ac.uk

College

Clare College

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    Research at Cambridge