University Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

PepSpace: An Automated, Physics-Driven Directed Evolution Platform for the De Novo Design of Specific Peptide Binders and Condensate Modulators
J Oller-Iscar, AR Tejedor, A Feito, M Velasco-Estevez, A Ocaña, R Collepardo-Guevara, JR Espinosa
(2026)
Molecular simulations of chromatin-associated biomolecular condensates.
MJ Maristany, K Russell, I Perez Lopez, J Huertas, R Collepardo-Guevara
Current Opinion in Structural Biology
(2026)
101
Capsid stabilization reprograms the nuclear fate of the HIV genome
T Mourer, M Harastani, C Cuche, JI Perez-Lopez, S Tornambe, S Tachon, G Corre, MJ Maristany, J-Y Tinevez, A Gazi, V Poletti, R Collepardo-Guevara, A Sartori-Rupp, F Di Nunzio
Science advances
(2026)
12
Compositional control of FUS condensate ageing through aggregation-prone interaction networks
E Pedraza, Ó Rebato, A Feito, F Gámez, P Llombart, AR Tejedor, R Collepardo-Guevara, JR Espinosa
(2026)
A Spectrum of Free Energy Landscape Topologies Encodes Chromatin Polymorphism and Phase Separation
Y Chen, J Huertas, MJ Maristany, K Russell, M Zhang, SE Farr, JR Espinosa, R Collepardo-Guevara
(2026)
hexABC seeking the physical code of DNA
F Battistini, M Wieczór, A Hospital, M Pasi, JP Arcón, I Serrano-Chacón, A Sala, S Deb, A García-Doñate, M Burman, EW Chan, L Chang, G da Rosa, JR Espinosa, GL Hoang, KA Hossain, M Jurkowski, R Poupon, R Sharma, R Sun, TC Bishop, P Carloni, TE Cheatham, R Collepardo-Guevara, J Czub, PD Dans, SA Harris, C Laughton, R Galindo-Murillo, JH Maddocks, A Noy, A Pérez, D Petkevičiūtė-Gerlach, M Orozco
Nat Commun
(2026)
17
Single-molecule nucleosome spacing coordinates chromatin fiber interactions
K Zhang, MJ Maristany, J Huertas, R Collepardo-Guevara, V Ramani
(2026)
RNA synthesis and degradation regulate biomolecular condensates through non-equilibrium feedback
I Sanchez-Burgos, AR Tejedor, A Ocana, JR Espinosa, R Collepardo-Guevara
(2026)
RNA2PS: A sequence-specific coarse-grained RNA model linking structure, thermodynamics and phase separation
AR Tejedor, J Luengo-Márquez, J Oller-Iscar, J Ramirez, A Ocana, R Collepardo-Guevara, P Llombart, JR Espinosa
(2026)
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells
MA Shimazoe, J Huertas, C Phillips, S Ide, S Tamura, S Farr, SS Ashwin, M Sasai, R Collepardo-Guevara, K Maeshima
Science Advances
(2026)
12

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