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Yusuf Hamied Department of Chemistry

University Lecturer

Rosana is an Interdisciplinary Associate Professor in the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Dr Collepardo discusses her research


Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– Nano letters
Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides.
J Gorman, SRE Orsborne, A Sridhar, R Pandya, P Budden, A Ohmann, NA Panjwani, Y Liu, JL Greenfield, S Dowland, V Gray, STJ Ryan, S De Ornellas, AH El-Sagheer, T Brown, JR Nitschke, J Behrends, UF Keyser, A Rao, R Collepardo-Guevara, E Stulz, RH Friend, F Auras
– J Am Chem Soc
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
J Joseph, A Reinhardt, A Aguirre, PY Chew, K Russell, J Rene Espinosa, A Garaizar, R Collepardo Guevara
– Nature Computational Science
Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
G da Rosa, L Grille, V Calzada, K Ahmad, JP Arcon, F Battistini, G Bayarri, T Bishop, P Carloni, T Cheatham, R Collepardo-Guevara, J Czub, JR Espinosa, R Galindo-Murillo, SA Harris, A Hospital, C Laughton, JH Maddocks, A Noy, M Orozco, M Pasi, A Pérez, D Petkevičiūtė-Gerlach, R Sharma, R Sun, PD Dans
– Biophysical Reviews
Intermolecular reorganisation of single-component condensates during ageing promotes multiphase architectures
A Garaizar, J Espinosa, J Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins
I Sanchez-Burgos, J Espinosa, J Joseph, R Collepardo-Guevara
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
A Garaizar, J Espinosa, J Joseph, R Collepardo-Guevara
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence
SM Lichtinger, A Garaizar, R Collepardo-Guevara, A Reinhardt
– PLoS computational biology
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
– Scientific Reports
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
SE Farr, EJ Woods, JA Joseph, A Garaizar, R Collepardo-Guevara
– Nature communications
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