University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Electrostatic control of chromatin compaction safeguards against apoptotic DNA release
(2026)
(doi: 10.64898/2026.02.23.707452)
Condensate-Driven Transcriptional Reprogramming Defines Core Vulnerabilities in Esophageal and Gastric Cancers
(2026)
(doi: 10.64898/2026.02.23.707358)
A Goldilocks zone of DNA flexibility defines stable yet plastic nucleosomes, tuned by histone chemistry
(2026)
(doi: 10.64898/2026.02.16.706184)
Determination of Nucleotide–Nucleotide and Nucleotide–Amino Acid Binding Interactions from All-Atom Potential-of-Mean-Force Calculations
ACS Physical Chemistry Au
(2026)
acsphyschemau.5c00120
Compositional Control of Aging Kinetics in TDP-43 Condensates
PRX Life
(2025)
3
043018
(doi: 10.1103/w7g3-6rsd)
Multiscale structure of chromatin condensates explains phase separation and material properties.
Science (New York, N.Y.)
(2025)
390
eadv6588
(doi: 10.1126/science.adv6588)
Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organization
Nar Genomics and Bioinformatics
(2025)
7
lqaf146
(doi: 10.1093/nargab/lqaf146)
Determination of nucleotide-nucleotide and nucleotide-amino acid binding interactions from all-atom potential-of-mean-force calculations
(2025)
(doi: 10.1101/2025.10.27.684844)
Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry
Nature Communications
(2025)
16
9296
(doi: 10.1038/s41467-025-64335-9)
Oct4 clusters promote DNA accessibility by enhancing chromatin plasticity
(2025)
(doi: 10.1101/2025.10.20.683403)
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