University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Capsid stabilization reprograms the nuclear fate of the HIV genome.
T Mourer, M Harastani, C Cuche, JI Perez-Lopez, S Tornambe, S Tachon, G Corre, MJ Maristany, J-Y Tinevez, A Gazi, V Poletti, R Collepardo-Guevara, A Sartori-Rupp, F Di Nunzio
Science advances
(2026)
12
Compositional control of FUS condensate ageing through aggregation-prone interaction networks
E Pedraza, Ó Rebato, A Feito, F Gámez, P Llombart, AR Tejedor, R Collepardo-Guevara, JR Espinosa
(2026)
A Spectrum of Free Energy Landscape Topologies Encodes Chromatin Polymorphism and Phase Separation
Y Chen, J Huertas, MJ Maristany, K Russell, M Zhang, SE Farr, JR Espinosa, R Collepardo-Guevara
(2026)
hexABC seeking the physical code of DNA
F Battistini, M Wieczór, A Hospital, M Pasi, JP Arcón, I Serrano-Chacón, A Sala, S Deb, A García-Doñate, M Burman, EW Chan, L Chang, G da Rosa, JR Espinosa, GL Hoang, KA Hossain, M Jurkowski, R Poupon, R Sharma, R Sun, TC Bishop, P Carloni, TE Cheatham, R Collepardo-Guevara, J Czub, PD Dans, SA Harris, C Laughton, R Galindo-Murillo, JH Maddocks, A Noy, A Pérez, D Petkevičiūtė-Gerlach, M Orozco
Nature communications
(2026)
17
Single-molecule nucleosome spacing coordinates chromatin fiber interactions
K Zhang, MJ Maristany, J Huertas, R Collepardo-Guevara, V Ramani
(2026)
RNA synthesis and degradation regulate biomolecular condensates through non-equilibrium feedback
I Sanchez-Burgos, AR Tejedor, A Ocana, JR Espinosa, R Collepardo-Guevara
(2026)
RNA2PS: A sequence-specific coarse-grained RNA model linking structure, thermodynamics and phase separation
AR Tejedor, J Luengo-Márquez, J Oller-Iscar, J Ramirez, A Ocana, R Collepardo-Guevara, P Llombart, JR Espinosa
(2026)
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells.
MA Shimazoe, J Huertas, C Phillips, S Ide, S Tamura, S Farr, SS Ashwin, M Sasai, R Collepardo-Guevara, K Maeshima
Sci Adv
(2026)
12
Length Scale-Dependent Dynamics in Electrostatic Protein Coacervates
E Pedraza, AR Tejedor, ÁS Zorita, R Collepardo-Guevara, D de Sancho, P Llombart, JR Espinosa
(2026)
Pushing the experimental resolution boundary in chromatin fibre organisation using multiscale simulations.
J Huertas, MJ Maristany, JI Perez-Lopez, R Collepardo-Guevara
Current Opinion in Genetics & Development
(2026)
98

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