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Yusuf Hamied Department of Chemistry

 

Rosana is an Interdisciplinary Lecturer in the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Dr Collepardo discusses her research

Publications

Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence.
SM Lichtinger, A Garaizar, R Collepardo-Guevara, A Reinhardt
– PLoS computational biology
(2021)
17,
e1009328
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients.
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
– Sci Rep
(2021)
11,
15241
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
SE Farr, EJ Woods, JA Joseph, A Garaizar, R Collepardo-Guevara
– Nat Commun
(2021)
12,
2883
Thermodynamics and kinetics of phase separation of protein-RNA mixtures by a minimal model
JA Joseph, JR Espinosa, I Sanchez-Burgos, A Garaizar, D Frenkel, R Collepardo-Guevara
– Biophys J
(2021)
120,
1219
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– Nature communications
(2021)
12,
1085
Valency and binding affinity variations can regulate the multilayered organization of protein condensates with many components
I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara
– Biomolecules
(2021)
11,
278
Reentrant Liquid Condensate Phase of Proteins is Stabilized by Hydrophobic and Non-Ionic interactions
G Krainer, TJ Welsh, JA Joseph, P St George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2021)
120,
28A
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
S Farr, E Woods, J Joseph, A Garaizar, R Collepardo-Guevara
(2020)
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions.
A Sandoval-Pérez, RML Berger, A Garaizar, SE Farr, MA Brehm, G König, SW Schneider, R Collepardo-Guevara, V Huck, JO Rädler, C Aponte-Santamaría
– Nucleic acids research
(2020)
48,
11812
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence
S Lichtinger, A Garaizar, R Collepardo-Guevara, A Reinhardt
(2020)
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Research Groups

Research Interest Group

Email address

rc597@cam.ac.uk