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Yusuf Hamied Department of Chemistry

 
University Lecturer

Rosana is an Interdisciplinary Associate Professor in the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Dr Collepardo discusses her research

Publications

Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– Nano letters
(2022)
acs.nanolett.1c03138
Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides.
J Gorman, SRE Orsborne, A Sridhar, R Pandya, P Budden, A Ohmann, NA Panjwani, Y Liu, JL Greenfield, S Dowland, V Gray, STJ Ryan, S De Ornellas, AH El-Sagheer, T Brown, JR Nitschke, J Behrends, UF Keyser, A Rao, R Collepardo-Guevara, E Stulz, RH Friend, F Auras
– J Am Chem Soc
(2021)
jacs.1c10241
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
J Joseph, A Reinhardt, A Aguirre, PY Chew, K Russell, J Rene Espinosa, A Garaizar, R Collepardo Guevara
– Nature Computational Science
(2021)
1,
732
Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
G da Rosa, L Grille, V Calzada, K Ahmad, JP Arcon, F Battistini, G Bayarri, T Bishop, P Carloni, T Cheatham, R Collepardo-Guevara, J Czub, JR Espinosa, R Galindo-Murillo, SA Harris, A Hospital, C Laughton, JH Maddocks, A Noy, M Orozco, M Pasi, A Pérez, D Petkevičiūtė-Gerlach, R Sharma, R Sun, PD Dans
– Biophysical Reviews
(2021)
13,
995
Intermolecular reorganisation of single-component condensates during ageing promotes multiphase architectures
A Garaizar, J Espinosa, J Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
(2021)
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins
I Sanchez-Burgos, J Espinosa, J Joseph, R Collepardo-Guevara
(2021)
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
A Garaizar, J Espinosa, J Joseph, R Collepardo-Guevara
(2021)
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence
SM Lichtinger, A Garaizar, R Collepardo-Guevara, A Reinhardt
– PLoS computational biology
(2021)
17,
e1009328
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
– Scientific Reports
(2021)
11,
15241
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
SE Farr, EJ Woods, JA Joseph, A Garaizar, R Collepardo-Guevara
– Nature communications
(2021)
12,
2883
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Research Groups

Research Interest Group

Email address

rc597@cam.ac.uk