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Yusuf Hamied Department of Chemistry

 

Dr Jenny Zhang

University Assistant Professor

"Life is nothing but an electron looking for a place to rest"  
- Albert Szent-Györgyi (Nobel Laureate in Physiology 1937)

Current research

My team's goal is to develop smart bio-hybrid approaches that can help to probe or re-wire the bioenergetics of living systems. These can serve as platforms to launch new biotechnologies to address a range of societal needs, including for renewable energy generation, carbon recycling, precision farming, environmental sensing, and treating pathogenic biofilms. Currently, we are focused on understanding and re-wiring photosynthesis towards sustainable energy conversion. We work at the intersection of many disciplines, including physics, synthetic biology, chemical biology, engineering and material science; but at the heart of our work is electrochemistry.

Please see our website for more info: https://www.ch.cam.ac.uk/group/zhang

**PhD positions available. Contact Jenny and attach your CV to enquire.**

Jenny completed her PhD in bioinorganic chemistry at the University of Sydney, Australia, with a brief stint at the Hebrew University of Jerusalem. During this time, she developed redox active platinum-based anti-cancer agents and studied their biodistribtion and metabolism within tumour models. Following this, she was awarded a Marie Curie Incoming International Fellowship at the University of Cambridge to explore how biocatalysts can be exploited to generate solar fuels. In particular, she worked on developing strategies to re-wire complex enzymes, such as the water-oxidation enzyme photosystem II, to electrodes/semiconductors/other proteins in an emerging field known as 'semi-artificial photosynthesis'. She has since been awarded a BBSRC David Phillips Fellowship, followed by appointment to Assistant Professor in Materials Chemistry at the Yusuf Hamied Department of Chemistry. Here, she takes on the re-wiring of photosynthesis to another level of complexity - in living cells! She was awarded the RSC Felix Franks Biotechnology Medal and the L'Oreal UNESCO Sustainable Development award for Women in Science.

Watch Dr Zhang discuss her research

Publications

The Development of Biophotovoltaic Systems for Power Generation and Biological Analysis.
LT Wey, P Bombelli, X Chen, JM Lawrence, CM Rabideau, SJL Rowden, JZ Zhang, CJ Howe
– ChemElectroChem
(2019)
6,
5375
(doi: 10.1002/celc.201900997)
Advancing Techniques for Investigating the Enzyme–Electrode Interface
N Kornienko, KH Ly, WE Robinson, N Heidary, JZ Zhang, E Reisner
– Accounts of chemical research
(2019)
52,
1439
(doi: 10.1021/acs.accounts.9b00087)
Structure-activity relationships of hierarchical three-dimensional electrodes with photosystem II for semi-artifcial photosynthesis
E Reisner, X Fang, KP Sokol, N Heidary, TA Kandiel, JZ Zhang
– Nano Lett
(2019)
19,
1844
(doi: 10.1021/acs.nanolett.8b04935)
Modulating the Cellular Uptake of Fluorescently Tagged Substrates of Prostate-Specific Antigen before and after Enzymatic Activation.
L Di Marco, JZ Zhang, J Doan, BJ Kim, N Yamamoto, NS Bryce, TW Hambley
– Bioconjugate Chemistry
(2019)
30,
124
(doi: 10.1021/acs.bioconjchem.8b00792)
Oxygenic Photoreactivity in Photosystem II Studied by Rotating Ring Disk Electrochemistry
N Kornienko, JZ Zhang, KP Sokol, S Lamaison, A Fantuzzi, R van Grondelle, AW Rutherford, E Reisner
– J Am Chem Soc
(2018)
140,
17923
(doi: 10.1021/jacs.8b08784)
Bias-free photoeletrochemical water splitting with photosystem II on a dye-sensitised photoanode wired to hydrogenase
KP Sokol, WE Robinson, J Warnan, N Kornienko, MM Nowaczyk, A Ruff, JZ Zhang, E Reisner
– Nature Energy
(2018)
3,
944
(doi: 10.1038/s41560-018-0232-y)
Interfacing nature's catalytic machinery with synthetic materials for semi-artificial photosynthesis
N Kornienko, JZ Zhang, KK Sakimoto, P Yang, E Reisner
– Nature nanotechnology
(2018)
13,
890
(doi: 10.1038/s41565-018-0251-7)
Solar Water Splitting with a Hydrogenase Integrated in Photoelectrochemical Tandem Cells
DH Nam, JZ Zhang, V Andrei, N Kornienko, N Heidary, A Wagner, K Nakanishi, KP Sokol, B Slater, I Zebger, S Hofmann, JC Fontecilla‐Camps, CB Park, E Reisner
– Angewandte Chemie
(2018)
130,
10755
(doi: 10.1002/ange.201805027)
Solar Water Splitting with a Hydrogenase Integrated in Photoelectrochemical Tandem Cells.
DH Nam, JZ Zhang, V Andrei, N Kornienko, N Heidary, A Wagner, K Nakanishi, KP Sokol, B Slater, I Zebger, S Hofmann, JC Fontecilla-Camps, CB Park, E Reisner
– Angewandte Chemie (International ed. in English)
(2018)
57,
10595
(doi: 10.1002/anie.201805027)
Photoelectrochemistry of photosystem II in vitro vs. in vivo
JZ Zhang, P Bombelli, KP Sokol, A Fantuzzi, AW Rutherford, CJ Howe, E Reisner
– J Am Chem Soc
(2017)
140,
6
(doi: 10.1021/jacs.7b08563)
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Research Group

Research Interest Groups

Telephone number

01223 336426

Email address

jz366@cam.ac.uk

College

Corpus Christi College

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