Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
K Sharma, AV Strizhak, E Fowler, W Xu, B Chappell, HF Sore, WRJD Galloway, MN Grayson, YH Lau, LS Itzhaki, DR Spring
– ACS omega
(2020)
5,
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
HL Stewart, AR Hanby, TA King, AD Bond, TA Moss, HF Sore, DR Spring
– Chemical Communications
(2020)
56,
C(sp3)–H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection
TJ Osberger, SL Kidd, TA King, DR Spring
– Chemical communications (Cambridge, England)
(2020)
56,
General dual functionalisation of biomacromolecules via a cysteine bridging strategy
SJ Walsh, J Iegre, H Seki, JD Bargh, HF Sore, JS Parker, JS Carroll, DR Spring
– Org Biomol Chem
(2020)
18,
Fsp 3 -rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery
AR Hanby, NS Troelsen, TJ Osberger, SL Kidd, KT Mortensen, DR Spring
– Chemical Communications
(2020)
56,
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
AV Strizhak, O Babii, S Afonin, I Bakanovich, T Pantelejevs, W Xu, E Fowler, R Eapen, K Sharma, MO Platonov, VV Hurmach, L Itzhaki, M Hyvönen, AS Ulrich, DR Spring, IV Komarov
– Organic & Biomolecular Chemistry
(2020)
18,
Efficient and selective antibody modification with functionalised divinyltriazines.
AJ Counsell, SJ Walsh, NS Robertson, HF Sore, DR Spring
– Organic & Biomolecular Chemistry
(2020)
18,
Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman
– ACS Omega
(2019)
5,
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
A Venkitaraman
– Scientific Reports
(2019)
9,
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Scientific Reports
(2019)
9,
