Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angewandte Chemie International Edition
(2020)
59,
Epidemiological insights from a large-scale investigation of intestinal helminths in Medieval Europe
PG Flammer, H Ryan, SG Preston, S Warren, R Přichystalová, R Weiss, V Palmowski, S Boschert, K Fellgiebel, I Jasch-Boley, M-S Kairies, E Rümmele, D Rieger, B Schmid, B Reeves, R Nicholson, L Loe, C Guy, T Waldron, J Macháček, J Wahl, M Pollard, G Larson, AL Smith
– PLoS Negl Trop Dis
(2020)
14,
Adventures in drugging undruggable targets
DR Spring
– JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2020)
63,
Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin-Resistant Staphylococcus aureus (MRSA).
JJ Freudenreich, S Bartlett, NS Robertson, SL Kidd, S Forrest, HF Sore, WRJD Galloway, M Welch, DR Spring
– Chemmedchem
(2020)
15,
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.
DA Russell, HR Bridges, R Serreli, SL Kidd, N Mateu, TJ Osberger, HF Sore, J Hirst, DR Spring
– Journal of natural products
(2020)
83,
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, D Bellini, R Talon, J McLoughlin, T Krojer, A Aimon, A Bradley, M Fairhead, P Brear, L Díaz-Sáez, K McAuley, HF Sore, A Madin, DH O'Donovan, KVM Huber, M Hyvönen, F von Delft, CG Dowson, DR Spring
– Chem Sci
(2020)
11,
2-aminopyridine analogs inhibit both enzymes of the glyoxylate shunt in pseudomonas aeruginosa
AC McVey, S Bartlett, M Kajbaf, A Pellacani, V Gatta, P Tammela, DR Spring, M Welch
– International Journal of Molecular Biosciences (IJMS)
(2020)
21,
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.
PR Curran, CJ Radoux, MD Smilova, RA Sykes, AP Higueruelo, AR Bradley, BD Marsden, DR Spring, TL Blundell, AR Leach, WR Pitt, JC Cole
– Journal of chemical information and modeling
(2020)
60,
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
– Chem Commun (Camb)
(2020)
56,
Sulfatase-cleavable linkers for antibody-drug conjugates.
JD Bargh, SJ Walsh, A Isidro-Llobet, S Omarjee, JS Carroll, DR Spring
– Chemical Science
(2020)
11,
