Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells
DA Russell, HR Bridges, R Serreli, SL Kidd, N Mateu, TJ Osberger, HF Sore, J Hirst, DR Spring
Journal of Natural Products
(2020)
83
(doi: 10.1021/acs.jnatprod.9b01224)
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, D Bellini, R Talon, J McLoughlin, T Krojer, A Aimon, A Bradley, M Fairhead, P Brear, L Díaz-Sáez, K McAuley, HF Sore, A Madin, DH O'Donovan, KVM Huber, M Hyvönen, F von Delft, CG Dowson, DR Spring
Chemical Science
(2020)
11
(doi: 10.1039/d0sc01232g)
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa.
AC McVey, S Bartlett, M Kajbaf, A Pellacani, V Gatta, P Tammela, DR Spring, M Welch
International Journal of Molecular Biosciences (IJMS)
(2020)
21
(doi: 10.3390/ijms21072490)
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design
PR Curran, CJ Radoux, MD Smilova, RA Sykes, AP Higueruelo, AR Bradley, BD Marsden, DR Spring, TL Blundell, AR Leach, WR Pitt, JC Cole
J. Chem. Inf. Model.
(2020)
60
(doi: 10.1021/acs.jcim.9b00996)
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
Chem Commun (Camb)
(2020)
56
(doi: 10.1039/c9cc09050a)
Sulfatase-cleavable linkers for antibody-drug conjugates.
JD Bargh, SJ Walsh, A Isidro-Llobet, S Omarjee, JS Carroll, DR Spring
Chem Sci
(2020)
11
(doi: 10.1039/c9sc06410a)
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
K Sharma, AV Strizhak, E Fowler, W Xu, B Chappell, HF Sore, WRJD Galloway, MN Grayson, YH Lau, LS Itzhaki, DR Spring
ACS Omega
(2020)
5
(doi: 10.1021/acsomega.9b03459)
C(sp3)-H arylation to construct all-: Syn cyclobutane-based heterobicyclic systems: A novel fragment collection
TJ Osberger, SL Kidd, TA King, DR Spring
Chemical Communications
(2020)
56
(doi: 10.1039/d0cc03237a)
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
AV Strizhak, O Babii, S Afonin, I Bakanovich, T Pantelejevs, W Xu, E Fowler, R Eapen, K Sharma, MO Platonov, VV Hurmach, L Itzhaki, M Hyvönen, AS Ulrich, DR Spring, IV Komarov
Organic & biomolecular chemistry
(2020)
18
(doi: 10.1039/d0ob00831a)
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds.
HL Stewart, AR Hanby, TA King, AD Bond, TA Moss, HF Sore, DR Spring
Chem Commun (Camb)
(2020)
56
(doi: 10.1039/d0cc02728f)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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