Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Site-selective modification strategies in antibody–drug conjugates
SJ Walsh, JD Bargh, FM Dannheim, AR Hanby, H Seki, AJ Counsell, X Ou, E Fowler, N Ashman, Y Takada, A Isidro-Llobet, JS Parker, JS Carroll, DR Spring
Chem Soc Rev
(2020)
50
(doi: 10.1039/d0cs00310g)
Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
J Charoenpattarapreeda
(2020)
(doi: 10.17863/CAM.64118)
Photocatalytic methods for amino acid modification.
TA King, J Mandrup Kandemir, SJ Walsh, DR Spring
Chem Soc Rev
(2020)
50
(doi: 10.1039/d0cs00344a)
The development of sulfatase-cleavable linkers for antibody-drug conjugates
J Bargh
(2020)
(doi: 10.17863/CAM.64165)
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
Angew Chem Int Ed Engl
(2020)
59
(doi: 10.1002/anie.202010090)
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
Angewandte Chemie
(2020)
132
(doi: 10.1002/ange.202010090)
Molecular-genetic characterisation of arginine auxotrophy in the opportunistic human pathogen, Pseudomonas aeruginosa
V Mohan
(2020)
(doi: 10.17863/cam.69740)
Studies within fragment-based drug discovery : library synthesis and hit-to-lead optimisation
A Sveiczer
(2020)
(doi: 10.17863/CAM.63171)
Epidemiological insights from a large-scale investigation of intestinal helminths in Medieval Europe.
PG Flammer, H Ryan, SG Preston, S Warren, R Přichystalová, R Weiss, V Palmowski, S Boschert, K Fellgiebel, I Jasch-Boley, M-S Kairies, E Rümmele, D Rieger, B Schmid, B Reeves, R Nicholson, L Loe, C Guy, T Waldron, J Macháček, J Wahl, M Pollard, G Larson, AL Smith
PLOS Neglected Tropical Diseases
(2020)
14
(doi: 10.1371/journal.pntd.0008600)
The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
J Gaynord
(2020)
(doi: 10.17863/CAM.59572)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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