Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angewandte Chemie
(2020)
132,
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angew Chem Int Ed Engl
(2020)
59,
Epidemiological insights from a large-scale investigation of intestinal helminths in Medieval Europe.
PG Flammer, H Ryan, SG Preston, S Warren, R Přichystalová, R Weiss, V Palmowski, S Boschert, K Fellgiebel, I Jasch-Boley, M-S Kairies, E Rümmele, D Rieger, B Schmid, B Reeves, R Nicholson, L Loe, C Guy, T Waldron, J Macháček, J Wahl, M Pollard, G Larson, AL Smith
– PLoS neglected tropical diseases
(2020)
14,
Adventures in drugging undruggable targets
DR Spring
– JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2020)
63,
Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin-Resistant Staphylococcus aureus (MRSA).
JJ Freudenreich, S Bartlett, NS Robertson, SL Kidd, S Forrest, HF Sore, WRJD Galloway, M Welch, DR Spring
– ChemMedChem
(2020)
15,
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells
DA Russell, HR Bridges, R Serreli, SL Kidd, N Mateu, TJ Osberger, HF Sore, J Hirst, DR Spring
– Journal of Natural Products
(2020)
83,
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, D Bellini, R Talon, J McLoughlin, T Krojer, A Aimon, A Bradley, M Fairhead, P Brear, L Díaz-Sáez, K McAuley, HF Sore, A Madin, DH O'Donovan, KVM Huber, M Hyvönen, F von Delft, CG Dowson, DR Spring
– Chemical science
(2020)
11,
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa.
AC McVey, S Bartlett, M Kajbaf, A Pellacani, V Gatta, P Tammela, DR Spring, M Welch
– International Journal of Molecular Sciences
(2020)
21,
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design
PR Curran, CJ Radoux, MD Smilova, RA Sykes, AP Higueruelo, AR Bradley, BD Marsden, DR Spring, TL Blundell, AR Leach, WR Pitt, JC Cole
– J. Chem. Inf. Model.
(2020)
60,
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
– Chemical Communications
(2020)
56,
