Professor David Spring

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.

K Sharma, AV Strizhak, E Fowler, W Xu, B Chappell, HF Sore, WRJD Galloway, MN Grayson, YH Lau, LS Itzhaki, DR Spring

ACS omega

(2020)

1157

(doi: 10.1021/acsomega.9b03459)

Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.

AR Hanby, NS Troelsen, TJ Osberger, SL Kidd, KT Mortensen, DR Spring

Chemical Communications

(2020)

2280

(doi: 10.1039/c9cc09796a)

General dual functionalisation of biomacromolecules via a cysteine bridging strategy.

SJ Walsh, J Iegre, H Seki, JD Bargh, HF Sore, JS Parker, JS Carroll, DR Spring

Organic & Biomolecular Chemistry

(2020)

4224

(doi: 10.1039/d0ob00907e)

C(sp 3 )–H arylation to construct all- syn cyclobutane-based heterobicyclic systems: a novel fragment collection

TJ Osberger, SL Kidd, TA King, DR Spring

Chemical communications (Cambridge, England)

(2020)

7423

(doi: 10.1039/d0cc03237a)

Efficient and selective antibody modification with functionalised divinyltriazines

AJ Counsell, SJ Walsh, NS Robertson, HF Sore, DR Spring

Organic & biomolecular chemistry

(2020)

4739

(doi: 10.1039/d0ob01002b)

An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds

HL Stewart, AR Hanby, TA King, AD Bond, TA Moss, HF Sore, DR Spring

Chem Commun (Camb)

(2020)

6818

(doi: 10.1039/d0cc02728f)

Diarylethene moiety as an enthalpy-entropy switch: Photoisomerizable stapled peptides for modulating p53/MDM2 interaction

AV Strizhak, O Babii, S Afonin, I Bakanovich, T Pantelejevs, W Xu, E Fowler, R Eapen, K Sharma, MO Platonov, VV Hurmach, L Itzhaki, M Hyvönen, AS Ulrich, DR Spring, IV Komarov

Organic & biomolecular chemistry

(2020)

5359

(doi: 10.1039/d0ob00831a)

Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.

DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman

ACS Omega

(2019)

822

(doi: 10.1021/acsomega.9b03626)

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

A Recino, K Barkan, A Schmidt-Christensen, J Nilsson, N Holmes, D Howie, D Holmberg, P Larsson, M Flodström-Tullberg, L Laraia, DR Spring, J Hecksher-Sørensen, A Cooke, G Ladds, M Wållberg

(2019)

845776

(doi: 10.1101/845776)

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman

Scientific Reports

(2019)

15930

(doi: 10.1038/s41598-019-50702-2)

Professor David Spring

Professor of Chemistry & Chemical Biology

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

Teaching

Publications

Publications

Research Group

Research Interest Groups

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Email address

College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge