Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.
AR Hanby, NS Troelsen, TJ Osberger, SL Kidd, KT Mortensen, DR Spring
Chemical communications (Cambridge, England)
(2020)
56
(doi: 10.1039/c9cc09796a)
Efficient and selective antibody modification with functionalised divinyltriazines.
AJ Counsell, SJ Walsh, NS Robertson, HF Sore, DR Spring
Org Biomol Chem
(2020)
18
(doi: 10.1039/d0ob01002b)
C(sp3)-H arylation to construct all-syncyclobutane-based heterobicyclic systems: a novel fragment collection
TJ Osberger, SL Kidd, TA King, DR Spring
Chemical communications (Cambridge, England)
(2020)
56
(doi: 10.1039/d0cc03237a)
General dual functionalisation of biomacromolecules via a cysteine bridging strategy.
SJ Walsh, J Iegre, H Seki, JD Bargh, HF Sore, JS Parker, JS Carroll, DR Spring
Organic & Biomolecular Chemistry
(2020)
18
(doi: 10.1039/d0ob00907e)
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
HL Stewart, AR Hanby, TA King, AD Bond, TA Moss, HF Sore, DR Spring
Chemical Communications
(2020)
56
(doi: 10.1039/d0cc02728f)
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
AV Strizhak, O Babii, S Afonin, I Bakanovich, T Pantelejevs, W Xu, E Fowler, R Eapen, K Sharma, MO Platonov, VV Hurmach, L Itzhaki, M Hyvönen, AS Ulrich, DR Spring, IV Komarov
Org Biomol Chem
(2020)
18
(doi: 10.1039/d0ob00831a)
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman
ACS omega
(2019)
5
(doi: 10.1021/acsomega.9b03626)
GLP-1R is downregulated in beta cells of NOD mice and T1D patients
A Recino, K Barkan, A Schmidt-Christensen, J Nilsson, N Holmes, D Howie, D Holmberg, P Larsson, M Flodström-Tullberg, L Laraia, DR Spring, J Hecksher-Sørensen, A Cooke, G Ladds, M Wållberg
(2019)
(doi: 10.1101/845776)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
Scientific Reports
(2019)
9
(doi: 10.1038/s41598-019-50702-2)
Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling
A Renzetti, RN Rutherford, K Fukumoto, D Kunciw, HF Sore, DR Spring
Synlett
(2019)
30
(doi: 10.1055/s-0039-1690217)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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