Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Designed analogues of the aplyronines for next-generation antibody-drug conjugates
R Porter, T Pettigrew, I Paterson, D Spring, J Parker
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257
Sulfatase-cleavable linkers for antibody-drug conjugates (ADCs)
J Bargh, S Walsh, A Isidro-Llobet, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
258
Photoswitchable PROTACs: Visible light activated degradation of the androgen receptor
E Fowler, A Hock, D O'Donovan, J Gorman, G Fumagalli, R Friend, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
258
A General Approach for the Site-Selective Modification of Native Proteins, Enabling the Generation of Stable and Functional Antibody-Drug Conjugates
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
Chem Sci
(2019)
10
(doi: 10.1039/c8sc04645j)
Development of novel CK2 inhibitors: From small molecules to conformationally constrained peptides targeting allosteric binding sites
J Iegre, P Brear, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257
Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of Pseudonocardia sp. natural products.
SM Geddis, T Coroama, S Forrest, JT Hodgkinson, M Welch, DR Spring
Beilstein Journal of Organic Chemistry
(2018)
14
(doi: 10.3762/bjoc.14.245)
Recent applications of diversity-oriented synthesis Toward novel, 3-dimensional fragment collections
SL Kidd, TJ Osberger, N Mateu, HF Sore, DR Spring
Front Chem
(2018)
6
(doi: 10.3389/fchem.2018.00460)
Molecular archaeoparasitology identifies cultural changes in the Medieval Hanseatic trading centre of Lubeck
PG Flammer, S Dellicour, SG Preston, D Rieger, S Warren, CKW Tan, R Nicholson, R Přichystalová, N Bleicher, J Wahl, NR Faria, OG Pybus, M Pollard, AL Smith
Proc Biol Sci
(2018)
285
(doi: 10.1098/rspb.2018.0991)
Synthesis of structurally diverse biflavonoids
TJ Sum, TH Sum, WRJD Galloway, DG Twigg, JJ Ciardiello, DR Spring
Tetrahedron
(2018)
74
(doi: 10.1016/j.tet.2018.05.003)
Synthesis of structurally diverse N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters
N Mateu, SL Kidd, L Kalash, HF Sore, A Madin, A Bender, DR Spring
Chemistry A European Journal
(2018)
24
(doi: 10.1002/chem.201803143)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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