Professor David Spring | Page 11 | Yusuf Hamied Department of Chemistry

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Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Molecular archaeoparasitology identifies cultural changes in the Medieval Hanseatic trading centre of Lübeck

PG Flammer, S Dellicour, SG Preston, D Rieger, S Warren, CKW Tan, R Nicholson, R Přichystalová, N Bleicher, J Wahl, NR Faria, OG Pybus, M Pollard, AL Smith

– Proceedings of the Royal Society B: Biological Sciences

(2018)

285,

20180991

(doi: 10.1098/rspb.2018.0991)

Synthesis of structurally diverse biflavonoids

TJ Sum, TH Sum, WRJD Galloway, DG Twigg, JJ Ciardiello, DR Spring

– Tetrahedron

(2018)

74,

5089

(doi: 10.1016/j.tet.2018.05.003)

Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

N Mateu, SL Kidd, L Kalash, HF Sore, A Madin, A Bender, DR Spring

– Chemistry (Weinheim an der Bergstrasse, Germany)

(2018)

24,

13681

(doi: 10.1002/chem.201803143)

Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol

DA Russell, JJ Freudenreich, HL Stewart, AD Bond, HF Sore, DR Spring

– Organic & Biomolecular Chemistry

(2018)

16,

6395

(doi: 10.1039/c8ob01919c)

Two-component stapling of biologically active and conformationally constrained peptides: past, present and future

J Iegre, JS Gaynord, NS Robertson, HF Sore, M Hyvönen, DR Spring

– Advanced Therapeutics

(2018)

1,

1800052

(doi: 10.1002/adtp.201800052)

Novel non-ATP competitive small molecules targeting the CK2 α/β interface.

P Brear, AJP North, J Iegre, K Hadje Georgiou, A Lubin, L Carro, W Green, H Sore, M Hyvonen, D Spring

– Bioorganic and Medicinal Chemistry

(2018)

26,

3016

(doi: 10.1016/j.bmc.2018.05.011)

Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons

E Bilsland, TA Tavella, R Krogh, JE Stokes, A Roberts, J Ajioka, DR Spring, AD Andricopulo, FTM Costa, SG Oliver

– BMC Biotechnol

(2018)

18,

22

(doi: 10.1186/s12896-018-0428-z)

Studies Towards the Synthesis of the Core of Endiandric Acid H

S Zheng, D Yang, R Zhu, DR Spring

– Chemistry of Natural Compounds

(2018)

54,

289

(doi: 10.1007/s10600-018-2326-y)

Bioinspired Total Synthesis of Bussealin E.

DG Twigg, L Baldassarre, EC Frye, WRJD Galloway, DR Spring

– Org Lett

(2018)

20,

1597

(doi: 10.1021/acs.orglett.8b00340)

Loving the poison: The methylcitrate cycle and bacterial pathogenesis

SK Dolan, A Wijaya, SM Geddis, DR Spring, R Silva-Rocha, M Welch

– Microbiology (United Kingdom)

(2018)

164,

251

(doi: 10.1099/mic.0.000604)