Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol.

DA Russell, JJ Freudenreich, HL Stewart, AD Bond, HF Sore, DR Spring

Organic & Biomolecular Chemistry

(2018)

16

6395

(doi: 10.1039/c8ob01919c)

Two-component stapling of biologically active and conformationally constrained peptides: past, present and future

J Iegre, JS Gaynord, NS Robertson, HF Sore, M Hyvönen, DR Spring

Advanced Therapeutics

(2018)

1

1800052

(doi: 10.1002/adtp.201800052)

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

P Brear, AJP North, J Iegre, K Hadje Georgiou, A Lubin, L Carro, W Green, H Sore, M Hyvonen, D Spring

Bioorg Med Chem

(2018)

26

3016

(doi: 10.1016/j.bmc.2018.05.011)

Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons

E Bilsland, TA Tavella, R Krogh, JE Stokes, A Roberts, J Ajioka, DR Spring, AD Andricopulo, FTM Costa, SG Oliver

BMC biotechnology

(2018)

18

22

(doi: 10.1186/s12896-018-0428-z)

Studies Towards the Synthesis of the Core of Endiandric Acid H

S Zheng, D Yang, R Zhu, DR Spring

Chemistry of Natural Compounds

(2018)

54

289

(doi: 10.1007/s10600-018-2326-y)

Bioinspired Total Synthesis of Bussealin E

DG Twigg, L Baldassarre, EC Frye, WRJD Galloway, DR Spring

Organic Letters

(2018)

20

1597

(doi: 10.1021/acs.orglett.8b00340)

Loving the poison: the methylcitrate cycle and bacterial pathogenesis.

SK Dolan, A Wijaya, SM Geddis, DR Spring, R Silva-Rocha, M Welch

Microbiology United Kingdom

(2018)

164

251

(doi: 10.1099/mic.0.000604)

Site-selective generation of stable antibody-drug conjugates via cysteine bridging of native antibodies

S Walsh, S Omarjee, M Hyvonen, J Carroll, D Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2018)

256

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking

AV Strizhak, K Sharma, O Babii, S Afonin, AS Ulrich, IV Komarov, DR Spring

Organic & Biomolecular Chemistry

(2018)

16

8559

(doi: 10.1039/C8OB02428F)

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

NS Robertson, DR Spring

Molecules

(2018)

23

E959

(doi: 10.3390/molecules23040959)