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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking.
AV Strizhak, K Sharma, O Babii, S Afonin, AS Ulrich, IV Komarov, DR Spring
– Organic and Biomolecular Chemistry
(2018)
16,
8559
(doi: 10.1039/c8ob02428f)
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets.
J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring
– Chemical science
(2018)
9,
4638
(doi: 10.1039/x0xx00000x)
Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions
NS Robertson, DR Spring
– Molecules
(2018)
23,
959
(doi: 10.3390/molecules23040959)
Synthesis of diverse semi-saturated bicyclic heteroaromatics
H Stewart, T Moss, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256,
(link to publication)
Diversity-oriented synthesis for the generation of N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters
S Kidd, N Mateu-Sanchis, A Madin, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256,
(link to publication)
Second-generation CK2α inhibitors targeting the αD pocket.
J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, L Carro, HF Sore, M Hyvönen, DR Spring
– Chem Sci
(2018)
9,
3041
(doi: 10.1039/c7sc05122k)
Adventures in Drugging Undruggable Targets
D Spring
– JOURNAL OF PEPTIDE SCIENCE
(2018)
24,
S44
(link to publication)
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone
DA Russell, WJS Fong, DG Twigg, HF Sore, DR Spring
– Journal of natural products
(2017)
80,
2751
(doi: 10.1021/acs.jnatprod.7b00527)
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
– Biochemistry
(2017)
56,
5539
(doi: 10.1021/acs.biochem.7b00852)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
– Angewandte Chemie
(2017)
129,
13046
(doi: 10.1002/ange.201705611)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

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