Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Synthesis of diverse semi-saturated bicyclic heteroaromatics
H Stewart, T Moss, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Second-generation CK2α inhibitors targeting the αD pocket
J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, L Carro, HF Sore, M Hyvönen, DR Spring
Chemical science
(2018)
9
(doi: 10.1039/c7sc05122k)
Adventures in Drugging Undruggable Targets
D Spring
JOURNAL OF PEPTIDE SCIENCE
(2018)
24
Diversity-oriented synthesis for the generation of N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters
S Kidd, N Mateu-Sanchis, A Madin, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring
Chemical science
(2018)
9
(doi: 10.1039/c8sc00284c)
Stereocontrolled Semi-Syntheses of Elliptone and 12aβ-Hydroxyelliptone
DA Russell, WJS Fong, DG Twigg, HF Sore, DR Spring
J Nat Prod
(2017)
80
(doi: 10.1021/acs.jnatprod.7b00527)
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
Biochemistry
(2017)
56
(doi: 10.1021/acs.biochem.7b00852)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
Angewandte Chemie
(2017)
129
(doi: 10.1002/ange.201705611)
Identification of new quorum sensing autoinducer binding partners in: Pseudomonas aeruginosa using photoaffinity probes
YR Baker, JT Hodgkinson, BI Florea, E Alza, WRJD Galloway, L Grimm, SM Geddis, HS Overkleeft, M Welch, DR Spring
Chem. Sci.
(2017)
8
(doi: 10.1039/c7sc01270e)
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
Chem Commun (Camb)
(2017)
53
(doi: 10.1039/c7cc05379g)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge