Professor David Spring

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Bioinspired Total Synthesis of Bussealin e

DG Twigg, L Baldassarre, EC Frye, WRJD Galloway, DR Spring

Organic letters

(2018)

1597

(doi: 10.1021/acs.orglett.8b00340)

Loving the poison: The methylcitrate cycle and bacterial pathogenesis

SK Dolan, A Wijaya, SM Geddis, DR Spring, R Silva-Rocha, M Welch

Microbiology (Reading, England)

(2018)

164

251

(doi: 10.1099/mic.0.000604)

Second-generation CK2α inhibitors targeting the αD pocket

J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, L Carro, HF Sore, M Hyvönen, DR Spring

Chemical science

(2018)

3041

(doi: 10.1039/c7sc05122k)

Site-selective generation of stable antibody-drug conjugates via cysteine bridging of native antibodies

S Walsh, S Omarjee, M Hyvonen, J Carroll, D Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2018)

256

Stapled peptides as a new technology to investigate protein-protein interactions in human platelets

J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring

Chem Sci

(2018)

4638

(doi: 10.1039/x0xx00000x)

Highly Reactive Bis-Cyclooctyne-Modified Diarylethene for SPAAC-mediated Cross-Linking

AV Strizhak, K Sharma, O Babii, S Afonin, AS Ulrich, IV Komarov, DR Spring

Organic & Biomolecular Chemistry

(2018)

8559

(doi: 10.1039/C8OB02428F)

The Application of Diversity-oriented Synthesis in Chemical Biology

N Mateu, SL Kidd, TJ Osberger, HL Stewart, S Bartlett, WRJD Galloway, AJP North, HF Sore, DR Spring

(2018)

Diversity-oriented synthesis for the generation of N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters

S Kidd, N Mateu-Sanchis, A Madin, D Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2018)

256

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

NS Robertson, DR Spring

Molecules

(2018)

E959

(doi: 10.3390/molecules23040959)

Adventures in Drugging Undruggable Targets

D Spring

JOURNAL OF PEPTIDE SCIENCE

(2018)

S44

Professor David Spring

Professor of Chemistry & Chemical Biology

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

Teaching

Publications

Publications

Research Group

Research Interest Groups

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Email address

College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge