Professor David Spring

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Synthesis of diverse semi-saturated bicyclic heteroaromatics

H Stewart, T Moss, D Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2018)

256

Two-component stapling of biologically active and conformationally constrained peptides: past, present and future

J Iegre, JS Gaynord, NS Robertson, HF Sore, M Hyvönen, DR Spring

Advanced Therapeutics

(2018)

1800052

(doi: 10.1002/adtp.201800052)

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

P Brear, AJP North, J Iegre, K Hadje Georgiou, A Lubin, L Carro, W Green, H Sore, M Hyvonen, D Spring

Bioorganic and Medicinal Chemistry

(2018)

3016

(doi: 10.1016/j.bmc.2018.05.011)

Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons.

E Bilsland, TA Tavella, R Krogh, JE Stokes, A Roberts, J Ajioka, DR Spring, AD Andricopulo, FTM Costa, SG Oliver

BMC biotechnology

(2018)

(doi: 10.1186/s12896-018-0428-z)

Studies Towards the Synthesis of the Core of Endiandric Acid H

S Zheng, D Yang, R Zhu, DR Spring

Chemistry of Natural Compounds

(2018)

289

(doi: 10.1007/s10600-018-2326-y)

Bioinspired Total Synthesis of Bussealin e

DG Twigg, L Baldassarre, EC Frye, WRJD Galloway, DR Spring

Organic letters

(2018)

1597

(doi: 10.1021/acs.orglett.8b00340)

Loving the poison: the methylcitrate cycle and bacterial pathogenesis

SK Dolan, A Wijaya, SM Geddis, DR Spring, R Silva-Rocha, M Welch

Microbiology

(2018)

164

251

(doi: 10.1099/mic.0.000604)

Highly Reactive Bis-Cyclooctyne-Modified Diarylethene for SPAAC-mediated Cross-Linking

AV Strizhak, K Sharma, O Babii, S Afonin, AS Ulrich, IV Komarov, DR Spring

Organic and Biomolecular Chemistry

(2018)

8559

(doi: 10.1039/c8ob02428f)

Stapled peptides as a new technology to investigate protein-protein interactions in human platelets.

J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring

Chemical science

(2018)

4638

(doi: 10.1039/c8sc00284c)

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein-Protein Interactions

NS Robertson, DR Spring

Molecules (Basel, Switzerland)

(2018)

E959

(doi: 10.3390/molecules23040959)

Professor David Spring

Professor of Chemistry & Chemical Biology

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

Teaching

Publications

Publications

Research Group

Research Interest Groups

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College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge