Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Diversity-oriented synthesis for the generation of N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters
S Kidd, N Mateu-Sanchis, A Madin, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone
DA Russell, WJS Fong, DG Twigg, HF Sore, DR Spring
Journal of natural products
(2017)
80
(doi: 10.1021/acs.jnatprod.7b00527)
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa.
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
Biochemistry
(2017)
56
(doi: 10.1021/acs.biochem.7b00852)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
Angewandte Chemie
(2017)
129
(doi: 10.1002/ange.201705611)
Identification of new quorum sensing autoinducer binding partners in: Pseudomonas aeruginosa using photoaffinity probes
YR Baker, JT Hodgkinson, BI Florea, E Alza, WRJD Galloway, L Grimm, SM Geddis, HS Overkleeft, M Welch, DR Spring
Chem. Sci.
(2017)
8
(doi: 10.1039/c7sc01270e)
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
Chem Commun (Camb)
(2017)
53
(doi: 10.1039/c7cc05379g)
Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
Angewandte Chemie International Edition
(2017)
56
(doi: 10.1002/anie.201705611)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
Bioorganic & Medicinal Chemistry
(2017)
25
(doi: 10.1016/j.bmc.2017.04.037)
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
JJ Ciardiello, WRJD Galloway, CJ O'Connor, HF Sore, JE Stokes, Y Wu, DR Spring
Tetrahedron
(2017)
72
(doi: 10.1016/j.tet.2015.10.061)
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes
A Guarnieri-Ibáñez, F Medina, C Besnard, SL Kidd, DR Spring, J Lacour
Chemical Science
(2017)
8
(doi: 10.1039/c7sc00964j)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge