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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

(Z)-Selective Takai olefination of salicylaldehydes
SM Geddis, CE Hagerman, WRJD Galloway, HF Sore, JM Goodman, DR Spring
– Beilstein journal of organic chemistry
(2017)
13,
323
(doi: 10.3762/bjoc.13.35)
Macrocyclized Extended Peptides: Inhibiting the Substrate Recognition Domain of Tankyrase
W Xu, YH Lau, G Fischer, YS Tan, A Chattopadhyay, M de la Roche, M Hyvönen, C Verma, DR Spring, LS Itzhaki
– Journal of the American Chemical Society
(2017)
139,
2245
(doi: 10.1021/jacs.6b10234)
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
– Angewandte Chemie - International Edition
(2017)
56,
524
(doi: 10.1002/anie.201609427)
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
– Angewandte Chemie
(2017)
129,
539
(doi: 10.1002/ange.201609427)
A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine
JJ Ciardiello, HL Stewart, HF Sore, WRJD Galloway, DR Spring
– Bioorganic and Medicinal Chemistry
(2017)
25,
2825
(doi: 10.1016/j.bmc.2017.02.060)
Glyoxylate shunt as an antibacterial drug target
S Bartlett, A McVey, A Crousilles, M Welch, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
253,
(link to publication)
Strain-promoted double-click functionalised stapled peptides for inhibiting protein-protein interactions
K Sharma, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
254,
(link to publication)
Identification and development of small molecule inhibitors of the aggregation of amyloid β
S Collins, F Gielen, L van Vliet, G Kaminski, F Hollfelder, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
253,
(link to publication)
Divergent Synthesis of Quinolone Natural Products from $\textit{Pseudonocardia}$ sp. CL38489
SM Geddis, L Carro Santos, JT Hodgkinson, DR Spring
– European J Org Chem
(2016)
2016,
5799
(doi: 10.1002/ejoc.201601195)
C-H activation: Complex peptides made simple
S Bartlett, DR Spring
– Nature Chemistry
(2016)
9,
9
(doi: 10.1038/nchem.2701)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge