Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
Chemical science
(2019)
10
(doi: 10.1039/c9sc00798a)
Development of novel CK2 inhibitors: From small molecules to conformationally constrained peptides targeting allosteric binding sites
J Iegre, P Brear, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257
Designed analogues of the aplyronines for next-generation antibody-drug conjugates
R Porter, T Pettigrew, I Paterson, D Spring, J Parker
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
Y Wu, A Kaur, E Fowler, MM Wiedmann, R Young, WRJD Galloway, L Olsen, HF Sore, A Chattopadhyay, TT-L Kwan, W Xu, SJ Walsh, P de Andrade, M Janecek, S Arumugam, LS Itzhaki, YH Lau, DR Spring
ACS chemical biology
(2019)
14
(doi: 10.1021/acschembio.9b00063)
Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol.
RC Knighton, K Sharma, NS Robertson, DR Spring, M Wills
ACS omega
(2019)
4
(doi: 10.1021/acsomega.8b03634)
Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
Chemical science
(2019)
10
(doi: 10.1039/c8sc90248h)
A General Approach for the Site-Selective Modification of Native Proteins, Enabling the Generation of Stable and Functional Antibody-Drug Conjugates
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
Chemical science
(2019)
10
(doi: 10.1039/c8sc04645j)
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K Sharma, AV Strizhak, E Fowler, X Wang, W Xu, C Hatt Jensen, Y Wu, HF Sore, YH Lau, M Hyvönen, LS Itzhaki, DR Spring
Org Biomol Chem
(2019)
17
(doi: 10.1039/c9ob01745c)
Synthesis and biological evaluation of 1,2-disubstituted 4-quinolone analogues of Pseudonocardia sp. natural products
SM Geddis, T Coroama, S Forrest, JT Hodgkinson, M Welch, DR Spring
Beilstein Journal of Organic Chemistry
(2018)
14
(doi: 10.3762/bjoc.14.245)
Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections.
SL Kidd, TJ Osberger, N Mateu, HF Sore, DR Spring
Frontiers in Chemistry
(2018)
6
(doi: 10.3389/fchem.2018.00460)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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