Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
Chemical Communications
(2017)
53
(doi: 10.1039/c7cc05379g)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
Bioorg Med Chem
(2017)
25
(doi: 10.1016/j.bmc.2017.04.037)
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
JJ Ciardiello, WRJD Galloway, CJ O'Connor, HF Sore, JE Stokes, Y Wu, DR Spring
Tetrahedron
(2017)
72
(doi: 10.1016/j.tet.2015.10.061)
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes.
A Guarnieri-Ibáñez, F Medina, C Besnard, SL Kidd, DR Spring, J Lacour
Chem Sci
(2017)
8
(doi: 10.1039/c7sc00964j)
Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1–42)
TH Sum, TJ Sum, S Collins, WRJD Galloway, DG Twigg, F Hollfelder, DR Spring
Organic & Biomolecular Chemistry
(2017)
15
(doi: 10.1039/c7ob00804j)
Protein modification <i>via</i> alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst.
TT-L Kwan, O Boutureira, EC Frye, SJ Walsh, MK Gupta, S Wallace, Y Wu, F Zhang, HF Sore, WRJD Galloway, JW Chin, M Welch, GJL Bernardes, DR Spring
Chemical science
(2017)
8
(doi: 10.1039/c6sc05313k)
Stereocontrolled semi-syntheses of deguelin and tephrosin
DA Russell, JJ Freudenreich, JJ Ciardiello, HF Sore, DR Spring
Organic &amp; Biomolecular Chemistry
(2017)
15
(doi: 10.1039/c6ob02659a)
(Z)-Selective Takai olefination of salicylaldehydes.
SM Geddis, CE Hagerman, WRJD Galloway, HF Sore, JM Goodman, DR Spring
Beilstein journal of organic chemistry
(2017)
13
(doi: 10.3762/bjoc.13.35)
Macrocyclized Extended Peptides: Inhibiting the Substrate Recognition Domain of Tankyrase
W Xu, YH Lau, G Fischer, YS Tan, A Chattopadhyay, M de la Roche, M Hyvönen, C Verma, DR Spring, LS Itzhaki
Journal of the American Chemical Society
(2017)
139
(doi: 10.1021/jacs.6b10234)
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
Angewandte Chemie International Edition
(2017)
56
(doi: 10.1002/anie.201609427)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge