Professor David Spring | Page 15 | Yusuf Hamied Department of Chemistry

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Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Crystal structure of CK2alpha with (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoate bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5cx9/pdb)

Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5ctp/pdb)

Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoat bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5cu2/pdb)

Crystal structure of CK2alpha with 3-(3-chloro-4-(phenyl)benzylamino)propan-1-ol bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5ct0/pdb)

Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5cu0/pdb)

Importin-alpha in complex with HNF1-beta peptide

MM Wiedmann, S Aibara, DR Spring, M Stewart, J Brenton

(2016)

(doi: 10.2210/pdb5k9s/pdb)

Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers

TH Sum, TJ Sum, WRJD Galloway, S Collins, DG Twigg, F Hollfelder, DR Spring

– Molecules (Basel, Switzerland)

(2016)

21,

1230

(doi: 10.3390/molecules21091230)

Partially Saturated Bicyclic Heteroaromatics as an sp3‐Enriched Fragment Collection

DG Twigg, N Kondo, SL Mitchell, WRJD Galloway, HF Sore, A Madin, DR Spring

– Angew Chem Int Ed Engl

(2016)

55,

12479

(doi: 10.1002/anie.201606496)

A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

F Nie, DL Kunciw, D Wilcke, JE Stokes, WRJD Galloway, S Bartlett, HF Sore, DR Spring

– Angew Chem Int Ed Engl

(2016)

55,

11139

(doi: 10.1002/anie.201605460)

Crystal Structure of CK2alpha with 3,4-dichlorophenethylamine bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5clp/pdb)