Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.

MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring

Angewandte Chemie International Edition

(2017)

524

(doi: 10.1002/anie.201609427)

Glyoxylate shunt as an antibacterial drug target

S Bartlett, A McVey, A Crousilles, M Welch, D Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2017)

253

Strain-promoted double-click functionalised stapled peptides for inhibiting protein-protein interactions

K Sharma, D Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2017)

254

Identification and development of small molecule inhibitors of the aggregation of amyloid β

S Collins, F Gielen, L van Vliet, G Kaminski, F Hollfelder, D Spring

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2017)

253

A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.

JJ Ciardiello, HL Stewart, HF Sore, WRJD Galloway, DR Spring

Bioorganic & medicinal chemistry

(2017)

2825

(doi: 10.1016/j.bmc.2017.02.060)

Divergent Synthesis of Quinolone Natural Products from $\textit{Pseudonocardia}$ sp. CL38489

SM Geddis, L Carro Santos, JT Hodgkinson, DR Spring

European Journal of Organic Chemistry

(2016)

2016

5799

(doi: 10.1002/ejoc.201601195)

C-H activation: Complex peptides made simple.

S Bartlett, DR Spring

Nature Chemistry

(2016)

(doi: 10.1038/nchem.2701)

Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5ctp/pdb)

Crystal structure of CK2alpha with 3-(3-chloro-4-(phenyl)benzylamino)propan-1-ol bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5ct0/pdb)

Crystal structure of CK2alpha with (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoate bound

P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen

(2016)

(doi: 10.2210/pdb5cx9/pdb)

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

Teaching

Publications

Publications

Research Group

Research Interest Groups

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Email address

College

About the Department

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Study at Cambridge

About the University

Research at Cambridge