Selective Aurora A-TPX2 interaction inhibitors havein vivoefficacy as targeted anti-mitotic agents
S Stockwell, D Scott, G Fischer, E Guarino, T Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, T Perrior, T Blundell, D Spring, G McKenzie, C Abell, J Skidmore, A Venkitaraman, M Hyvönen
(2023)
A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
T Pantelejevs, P Zuazua-Villar, O Koczy, A Counsell, S Walsh, N Robertson, D Spring, J Downs, M Hyvönen
(2023)
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance
MA Lake, KN Adams, F Nie, E Fowler, AK Verma, S Dei, E Teodori, DR Sherman, PH Edelstein, DR Spring, M Troll, L Ramakrishnan
– Proceedings of the National Academy of Sciences
(2023)
120,
Peroxide-cleavable linkers for antibody–drug conjugates
N Ashman, JD Bargh, SJ Walsh, RD Greenwood, A Tiberghien, JS Carroll, DR Spring
– Chem Commun (Camb)
(2023)
59,
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
RCB Nicolescu, ZR Maylin, FJ Pérez‐Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
(2023)
18,
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
RCB Nicolescu, ZR Maylin, FJ Pérez-Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
(2022)
18,
Non-internalising antibody-drug conjugates
N Ashman, JD Bargh, DR Spring
– Chemical Society Reviews
(2022)
13,
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action.
P Brear, C De Fusco, EL Atkinson, J Iegre, NJ Francis-Newton, AR Venkitaraman, M Hyvönen, DR Spring
– RSC Med Chem
(2022)
13,
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
AR Hanby, SJ Walsh, AJ Counsell, N Ashman, KT Mortensen, JS Carroll, DR Spring
– Chem Commun (Camb)
(2022)
58,
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
– Chem Sci
(2022)
13,
