Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Novel immunotherapeutics against LGR5 to target multiple cancer types
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Ghodsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
EMBO Molecular Medicine
(2024)
16
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs †
R Walther, M Park, N Ashman, M Welch, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2024)
60
Towards the Targeted Protein Degradation of PRMT1.
PL Martin, FJ Pérez-Areales, SV Rao, SJ Walsh, JS Carroll, DR Spring
Chemmedchem
(2024)
19
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules
BM da S Santos, FG Finelli, DR Spring
Org Lett
(2024)
26
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2024)
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay-Williams, T Schober, RA Floto, DR Spring
Angew Chem Int Ed Engl
(2024)
63
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay‐Williams, T Schober, RA Floto, DR Spring
Angewandte Chemie
(2024)
136
CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
S Day-Riley, RM West, PD Brear, M Hyvönen, DR Spring
Kinases and Phosphatases
(2024)
2
Site-selective peptide functionalisation mediated via vinyl-triazine linchpins †
JD Sydenham, H Seki, S Krajcovicova, L Zeng, T Schober, T Deingruber, DR Spring
Chem Commun (Camb)
(2024)
60
Red-light modulated ortho -chloro azobenzene photoswitch for peptide stapling via aromatic substitution
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
RSC Chemical Biology
(2024)
5

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address