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Yusuf Hamied Department of Chemistry

 

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a two-minute tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Rapid and robust cysteine bioconjugation with vinylheteroarenes
H Seki, SJ Walsh, JD Bargh, JS Parker, J Carroll, DR Spring
– Chemical science
(2021)
12,
9060
Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs)
BM Cooper, J Iegre, DH O' Donovan, M Ölwegård Halvarsson, DR Spring
– Chemical Society Reviews
(2021)
50,
1480
Site-selective modification strategies in antibody-drug conjugates.
SJ Walsh, JD Bargh, FM Dannheim, AR Hanby, H Seki, AJ Counsell, X Ou, E Fowler, N Ashman, Y Takada, A Isidro-Llobet, JS Parker, JS Carroll, DR Spring
– Chem Soc Rev
(2021)
50,
1305
The role of chemical synthesis in developing RiPP antibiotics
SM Rowe, DR Spring
– Chem Soc Rev
(2021)
50,
4245
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics.
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angewandte Chemie - International Edition
(2020)
59,
23045
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angewandte Chemie
(2020)
132,
23245
Adventures in drugging undruggable targets
DR Spring
– JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2020)
63,
362
Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA)
JJ Freudenreich, S Bartlett, NS Robertson, SL Kidd, S Forrest, HF Sore, WRJD Galloway, M Welch, DR Spring
– ChemMedChem
(2020)
15,
1289
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells
DA Russell, HR Bridges, R Serreli, SL Kidd, N Mateu, TJ Osberger, HF Sore, J Hirst, DR Spring
– J Nat Prod
(2020)
83,
1829
2-aminopyridine analogs inhibit both enzymes of the glyoxylate shunt in pseudomonas aeruginosa
AC McVey, S Bartlett, M Kajbaf, A Pellacani, V Gatta, P Tammela, DR Spring, M Welch
– Int J Mol Sci
(2020)
21,
E2490
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk