Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Cysteine Re-bridging Using Divinyl Pyrimidine Reagents for the Generation of Antibody-Drug Conjugates.
T Wharton, S Krajcovicova, DR Spring
Methods in Molecular Biology Clifton N J
(2026)
3009
Boosting peptide half-life: enabling efficient generation of Fc–peptide conjugates
M Park, FM Dannheim, MA Papworth, R Kay, E Tsonou, D Trajkovski, SJ Walsh, D Hovdal, T Wharton, A-C Nassoy, JS Parker, DR Spring
Chem Sci
(2026)
17
Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder
RM West, RC Bizga Nicolescu, P Brear, J Wagstaff, BK Blaszczyk, T Deingruber, MG Sanders, FJ Pérez-Areales, DR Spring, M Hyvönen
J Med Chem
(2026)
69
Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.
S Day-Riley, S Krajcovicova, AR Sokhal, JL Venne, P Brear, M Hyvönen, BC Whitehurst, JS Carroll, DR Spring
Beilstein J Org Chem
(2026)
22
Bismuth Bicycles
S Voss, A Sagar, A Tiberghien, RJL Hughes, L Chen, I Rioja, M Frigerio, MJ Skynner, DR Spring
Journal of Peptide Science
(2026)
32
Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder
RM West, RCB Nicolescu, P Brear, J Wagstaff, BK Blaszczyk, T Deingruber, MG Sanders, FJ Pérez-Areales, DR Spring, M Hyvönen
(2025)
An allantoin-inducible glyoxylate utilization pathway in Pseudomonas aeruginosa.
SL Parkhill, O Little, I Askenasy, E Labrini, M Wang, PD Brear, W Cai, T Deingruber, T Yang, DR Spring, M Welch
Microbiology
(2025)
171
MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody-drug conjugates.
AJ Counsell, SJ Walsh, N Ashman, M Park, FM Dannheim, TA King, T Wharton, JS Carroll, DR Spring
Chemical Science
(2025)
17
Towards a glutathione-cleavable azobenzene linker for antibody-drug conjugates.
M Kapun, R Patel, M Park, FJ Pérez-Areales, KA Kostadinova, T Wharton, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2025)
61
Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds
K Zhu, DR Spring, B-F Shi, F Zhang
Chem Soc Rev
(2025)
54

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address