Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.
K Zhu, DR Spring, B-F Shi, F Zhang
Chem Soc Rev
(2025)
54
(doi: 10.1039/d5cs00235d)
Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors
PA Glossop, P Brear, S Wright, N Flanagan, MS Glossop, CAL Lane, RP Butt, DR Spring, M Hyvönen, D Cawkill
J Med Chem
(2025)
68
(doi: 10.1021/acs.jmedchem.5c01807)
β-Lactamase cleavable antimicrobial peptide-drug conjugates.
T Deingruber, JS Gaynord, BH Gan, KA Kostadinova, TJ O'Brien, YS Tan, JS Parker, TA Hunt, JS Carroll, M Welch, DR Spring
Chemical science
(2025)
16
(doi: 10.1039/d5sc06369h)
Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome.
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, DR Spring, C Lindon, C Phillips, LS Itzhaki
Elife
(2025)
14
(doi: 10.7554/eLife.104238)
A Dynamic Silver(I) Nanocluster Holds Together a 3 x 3 Self-Assembled Grid
AW Heard, L Pesce, PT Gierth, S Adorinni, TK Ronson, B Rossi, JD Thoburn, T Deingruber, M Welch, DR Spring, S Marchesan, GM Pavan, JR Nitschke
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c07271)
A platform for SpyCatcher conjugation to native antibodies
S Krajcovicova, T Wharton, CL Driscoll, TA King, MR Howarth, DR Spring
Chemical science
(2025)
16
(doi: 10.1039/d5sc02286j)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2025)
(doi: 10.7554/elife.104238.2)
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
T Wharton, DR Spring
ChemMedChem
(2025)
20
(doi: 10.1002/cmdc.202500132)
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity.
M Wang, P Medarametla, T Kronenberger, T Deingruber, P Brear, W Figueroa, P-M Ho, T Krueger, JC Pearce, A Poso, JG Wakefield, DR Spring, M Welch
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-57532-z)
Pseudomonas aeruginosa PfpI is a methylglyoxalase
L Grimm, A Wijaya, I Askenasy, RR Nazeer, H Seki, PD Brear, W Figueroa, DR Spring, M Welch
Journal of Biological Chemistry
(2025)
301
(doi: 10.1016/j.jbc.2025.108374)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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