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Yusuf Hamied Department of Chemistry

 

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Site-selective peptide functionalisation mediated via vinyl-triazine linchpins.
JD Sydenham, H Seki, S Krajcovicova, L Zeng, T Schober, T Deingruber, DR Spring
– Chemical Communications
(2024)
60,
706
Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
– RSC Chemical Biology
(2024)
5,
49
A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
T Pantelejevs, P Zuazua-Villar, O Koczy, AJ Counsell, SJ Walsh, NS Robertson, DR Spring, JA Downs, M Hyvönen
– Chemical science
(2023)
14,
13915
Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution.
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
– RSC Chemical Biology
(2023)
5,
49
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction
J Iegre, S Krajcovicova, A Gunnarsson, L Wissler, H Käck, A Luchniak, S Tångefjord, F Narjes, DR Spring
– Chemical Science
(2023)
14,
10800
Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
TA King, SJ Walsh, M Kapun, T Wharton, S Krajcovicova, MS Glossop, DR Spring
– Chemical communications (Cambridge, England)
(2023)
59,
9868
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
S Krajcovicova, DR Spring
– Angewandte Chemie International Edition
(2023)
62,
e202307782
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
S Krajcovicova, DR Spring
– Angewandte Chemie
(2023)
135,
e202307782
Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.
KT Mortensen, DSY Wong, TA King, HF Sore, DR Spring
– Organic & biomolecular chemistry
(2023)
21,
4591
Identification of macrocyclic peptides which activate bacterial cylindrical proteases.
R Walther, LM Westermann, S Carmali, SE Jackson, H Brötz-Oesterhelt, DR Spring
– RSC Med Chem
(2023)
14,
1186
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk