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Department of Chemistry

 
Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

Diversity-Oriented Synthesis
Synthetic Methodology
Protein-Protein Interactions
Quorum Sensing
New Antibiotics
Next Generation Therapeutics

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.

 

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

 

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
J Charoenpattarapreeda, YS Tan, J Iegre, SJ Walsh, E Fowler, RS Eapen, Y Wu, HF Sore, CS Verma, L Itzhaki, DR Spring
– Chem Commun (Camb)
(2019)
55,
7914
Strategies for the Diversity-Oriented Synthesis of Macrocycles
KT Mortensen, TJ Osberger, TA King, HF Sore, DR Spring
– Chem Rev
(2019)
acs.chemrev.9b00084
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
A Sveiczer, AJP North, N Mateu, SL Kidd, HF Sore, DR Spring
– Org Lett
(2019)
21,
4600
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
Y Wu, A Kaur, E Fowler, MM Wiedmann, R Young, WRJD Galloway, L Olsen, HF Sore, A Chattopadhyay, TT-L Kwan, W Xu, SJ Walsh, P de Andrade, M Janecek, S Arumugam, LS Itzhaki, YH Lau, DR Spring
– ACS Chemical Biology
(2019)
14,
526
Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1 '-Biphenyl-2,2 ',6,6 '-tetrol
RC Knighton, K Sharma, NS Robertson, DR Spring, M Wills
– ACS Omega
(2019)
4,
2160
Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
– Chem Sci
(2019)
10,
633
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
– Chem Sci
(2019)
10,
694
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
– Chemical science
(2019)
10,
5056
Synthesis and biological evaluation of 1,2-disubstituted 4-quinolone analogues of Pseudonocardia sp. Natural products
SM Geddis, T Coroama, S Forrest, JT Hodgkinson, M Welch, DR Spring
– Beilstein J Org Chem
(2018)
14,
2680
Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections
SL Kidd, TJ Osberger, N Mateu, HF Sore, DR Spring
– Frontiers in chemistry
(2018)
6,
460
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk