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Professor David Spring

Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

Diversity-Oriented Synthesis
Synthetic Methodology
Protein-Protein Interactions
Quorum Sensing
New Antibiotics
Next Generation Therapeutics

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.



If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.



For a list of all our publications please visit the Spring Group publication page.


Bioinspired Total Synthesis of Bussealin E.
DG Twigg, L Baldassarre, EC Frye, WRJD Galloway, DR Spring
– Organic letters
Loving the poison: the methylcitrate cycle and bacterial pathogenesis.
SK Dolan, A Wijaya, SM Geddis, DR Spring, R Silva-Rocha, M Welch
– Microbiology
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone.
DA Russell, WJS Fong, DG Twigg, HF Sore, DR Spring
– Journal of Natural Products
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
– Biochemistry
Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
– Angew Chem Int Ed Engl
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
– Chemical communications (Cambridge, England)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
– Bioorganic & medicinal chemistry
Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid beta (1-42)
TH Sum, TJ Sum, S Collins, WRJD Galloway, DG Twigg, F Hollfelder, DR Spring
– Org Biomol Chem
Protein modificationviaalkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst.
TT-L Kwan, O Boutureira, EC Frye, SJ Walsh, MK Gupta, S Wallace, Y Wu, F Zhang, HF Sore, WRJD Galloway, JW Chin, M Welch, GJL Bernardes, DR Spring
– Chem. Sci.
Stereocontrolled semi-syntheses of deguelin and tephrosin
DA Russell, JJ Freudenreich, JJ Ciardiello, HF Sore, DR Spring
– Org Biomol Chem
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address