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Yusuf Hamied Department of Chemistry


Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow


Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure



Watch Professor David Spring discuss his research

Take a two-minute tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.


If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.


For a list of all our publications please visit the Spring Group publication page.


All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
– Chemical Science
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent: In vivo efficacy and tolerability
SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring
– Chemical Communications
Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
– Chemical Society Reviews
Development of small cyclic peptides targeting the CK2α/β interface
EL Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvönen, DR Spring
– Chemical communications (Cambridge, England)
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
AR Hanby, SJ Walsh, AJ Counsell, N Ashman, KT Mortensen, JS Carroll, DR Spring
– Chem Commun (Camb)
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
D Guo, H Singh, A Shimoyama, C Guffick, Y Tang, SM Rowe, T Noel, DR Spring, K Fukase, HW van Veen
– Communications Biology
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides
G Fumagalli, RJ Carbajo, JWM Nissink, J Tart, R Dou, AP Thomas, DR Spring
– J Med Chem
Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
M Bourdon, J Gaynord, KH Müller, G Evans, S Wallis, P Aston, DR Spring, R Wightman
– BMC Plant Biology
The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
– Chem Soc Rev
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.
EL Atkinson, J Iegre, PD Brear, EA Zhabina, M Hyvönen, DR Spring
– Molecules (Basel, Switzerland)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address