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Department of Chemistry

Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

Diversity-Oriented Synthesis
Synthetic Methodology
Protein-Protein Interactions
Quorum Sensing
New Antibiotics
Next Generation Therapeutics

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.



If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.



For a list of all our publications please visit the Spring Group publication page.


Sulfatase-cleavable linkers for antibody-drug conjugates
JD Bargh, SJ Walsh, A Isidro-Llobet, S Omarjee, JS Carroll, DR Spring
– Chemical Science
Fsp 3 -rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery
AR Hanby, NS Troelsen, TJ Osberger, SL Kidd, KT Mortensen, DR Spring
– Chemical Communications
Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman
– ACS omega
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
– Chem Commun (Camb)
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.
K Sharma, AV Strizhak, E Fowler, W Xu, B Chappell, HF Sore, WRJD Galloway, MN Grayson, YH Lau, LS Itzhaki, DR Spring
– ACS Omega
Direct Synthesis of N -Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling
A Renzetti, RN Rutherford, K Fukumoto, D Kunciw, HF Sore, DR Spring
– Synlett
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Scientific Reports
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K Sharma, AV Strizhak, E Fowler, X Wang, W Xu, C Hatt Jensen, Y Wu, HF Sore, YH Lau, M Hyvönen, LS Itzhaki, DR Spring
– Organic & biomolecular chemistry
Cleavable linkers in antibody–drug conjugates
JD Bargh, A Isidro-Llobet, JS Parker, DR Spring
– Chem Soc Rev
Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
NS Robertson, SJ Walsh, E Fowler, M Yoshida, SM Rowe, Y Wu, HF Sore, JS Parker, DR Spring
– Chemical communications (Cambridge, England)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address