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Yusuf Hamied Department of Chemistry


Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow


Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure



Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.


If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.


For a list of all our publications please visit the Spring Group publication page.


Synthesis of sp 3 -rich Heterocyclic Frameworks by a Divergent Synthesis Strategy
KT Mortensen, DSY Wong, TA King, HF Sore, DR Spring
– Organic & Biomolecular Chemistry
Development of constrained peptide inhibitors targeting an oncogenic E3 ubiquitin ligase
G Zenkevičiūtė, W Xu, J Iegre, H Seki, YS Tan, PJE Rowling, F Ferrer, C Verma, D Spring, H Laman, L Itzhaki
Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents
SR Stockwell, DE Scott, G Fischer, E Guarino, TPC Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, TR Perrior, TL Blundell, DR Spring, G McKenzie, C Abell, J Skidmore, M Hyvönen, AR Venkitaraman
A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
T Pantelejevs, P Zuazua-Villar, O Koczy, A Counsell, S Walsh, N Robertson, D Spring, J Downs, M Hyvönen
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux, and macrophage-induced rifampicin tolerance
MA Lake, KN Adams, F Nie, E Fowler, AK Verma, S Dei, E Teodori, DR Sherman, PH Edelstein, DR Spring, M Troll, L Ramakrishnan
– Proc Natl Acad Sci U S A
Peroxide-cleavable linkers for antibody-drug conjugates.
N Ashman, JD Bargh, SJ Walsh, RD Greenwood, A Tiberghien, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
RCB Nicolescu, ZR Maylin, FJ Pérez‐Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI-001 in in vitro Models of Prostate Cancer Drug Resistance.
RCB Nicolescu, ZR Maylin, FJ Pérez-Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
Non-internalising antibody-drug conjugates
N Ashman, JD Bargh, DR Spring
– Chem Soc Rev
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
P Brear, C De Fusco, EL Atkinson, J Iegre, NJ Francis-Newton, AR Venkitaraman, M Hyvönen, DR Spring
– RSC Medicinal Chemistry
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Research Group

Research Interest Groups

Telephone number

01223 336498

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