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Yusuf Hamied Department of Chemistry

 

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Publisher Correction: Novel immunotherapeutics against LGR5 to target multiple cancer types
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Ghodsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
– EMBO Molecular Medicine
(2024)
1
Selective Aurora A-TPX2 interaction inhibitors have in vivo efficacy as targeted anti-mitotic agents
SR Stockwell, DE Scott, G Fischer, E Guarino, TPC Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, TR Perrior, TL Blundell, DR Spring, G McKenzie, C Abell, J Skidmore, AR Venkitaraman, M Hyvönen
– J Med Chem
(2024)
67,
15521
Novel immunotherapeutics against LGR5 to target multiple cancer types
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Godsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
– EMBO Mol Med
(2024)
16,
2233
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
R Walther, M Park, N Ashman, M Welch, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
(2024)
60,
7025
Towards the Targeted Protein Degradation of PRMT1
PL Martin, FJ Pérez-Areales, SV Rao, SJ Walsh, JS Carroll, DR Spring
– ChemMedChem
(2024)
19,
e202400269
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules
BM da S Santos, FG Finelli, DR Spring
– Org Lett
(2024)
26,
4065
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, E McCall, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, L Itzhaki
(2024)
Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules.
T Wharton, F Crawshay-Williams, T Schober, RA Floto, DR Spring
– Angew Chem Int Ed Engl
(2024)
63,
e202402267
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay‐Williams, T Schober, RA Floto, DR Spring
– Angewandte Chemie
(2024)
136,
e202402267
CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
S Day-Riley, RM West, PD Brear, M Hyvönen, DR Spring
– Kinases and Phosphatases
(2024)
2,
110
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk