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Yusuf Hamied Department of Chemistry

 

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Peroxide-cleavable linkers for antibody–drug conjugates †
N Ashman, JD Bargh, SJ Walsh, RD Greenwood, A Tiberghien, JS Carroll, DR Spring
– Chemical Communications
(2023)
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
RCB Nicolescu, ZR Maylin, FJ Pérez‐Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
(2023)
18,
Non-internalising antibody-drug conjugates.
N Ashman, JD Bargh, DR Spring
– Chemical Society Reviews
(2022)
13,
9182
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
RCB Nicolescu, ZR Maylin, FJ Pérez-Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
(2022)
18,
e202200548
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
P Brear, C De Fusco, EL Atkinson, J Iegre, NJ Francis-Newton, AR Venkitaraman, M Hyvönen, DR Spring
– RSC medicinal chemistry
(2022)
13,
1420
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy
AR Hanby, SJ Walsh, AJ Counsell, N Ashman, KT Mortensen, JS Carroll, DR Spring
– Chemical Communications
(2022)
58,
9401
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
– Chemical science
(2022)
13,
8781
Development of small cyclic peptides targeting the CK2 alpha/beta interface
EL Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvönen, DR Spring
– Chemical communications (Cambridge, England)
(2022)
58,
4791
Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability
SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring
– Chem Commun (Camb)
(2022)
58,
1962
Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
– Chem Soc Rev
(2022)
51,
792
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk