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Department of Chemistry

Portrait of drs36

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

Diversity-Oriented Synthesis
Synthetic Methodology
Protein-Protein Interactions
Quorum Sensing
New Antibiotics
Next Generation Therapeutics

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Research Interests

For more detailed information please visit the Spring Group research pages.



If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.



For a list of all our publications please visit the Spring Group publication page.


A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Sci Rep
Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery
TA King, HL Stewart, KT Mortensen, AJP North, HF Sore, DR Spring
– European Journal of Organic Chemistry
Cleavable linkers in antibody-drug conjugates
JD Bargh, A Isidro-Llobet, JS Parker, DR Spring
– Chemical Society Reviews
Macrocyclisation and functionalisation of unprotected peptides: Via divinyltriazine cysteine stapling
NS Robertson, SJ Walsh, E Fowler, M Yoshida, SM Rowe, Y Wu, HF Sore, JS Parker, DR Spring
– Chem Commun (Camb)
Strategies for the Diversity-Oriented Synthesis of Macrocycles
KT Mortensen, TJ Osberger, TA King, HF Sore, DR Spring
– Chemical Reviews
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
A Sveiczer, AJP North, N Mateu, SL Kidd, HF Sore, DR Spring
– Organic Letters
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
– Chemical Science
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides
Y Wu, A Kaur, E Fowler, MM Wiedmann, R Young, WRJD Galloway, L Olsen, HF Sore, A Chattopadhyay, TT-L Kwan, W Xu, SJ Walsh, P de Andrade, M Janecek, S Arumugam, LS Itzhaki, YH Lau, DR Spring
– ACS Chem Biol
Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1 '-Biphenyl-2,2 ',6,6 '-tetrol
RC Knighton, K Sharma, NS Robertson, DR Spring, M Wills
– ACS omega
Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
– Chemical science
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address