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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Chemical probes targeting the kinase CK2: a journey outside the catalytic box
J Iegre, EL Atkinson, PD Brear, BM Cooper, M Hyvönen, DR Spring
– Organic & biomolecular chemistry
(2021)
19,
4380
(doi: 10.1039/d1ob00257k)
Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)
BM Cooper, J Iegre, DH O' Donovan, M Ölwegård Halvarsson, DR Spring
– Chemical Society reviews
(2021)
50,
1480
(doi: 10.1039/d0cs00556h)
Site-selective modification strategies in antibody-drug conjugates.
SJ Walsh, JD Bargh, FM Dannheim, AR Hanby, H Seki, AJ Counsell, X Ou, E Fowler, N Ashman, Y Takada, A Isidro-Llobet, JS Parker, JS Carroll, DR Spring
– Chemical Society Reviews
(2020)
50,
1305
(doi: 10.1039/d0cs00310g)
Photocatalytic methods for amino acid modification.
TA King, J Mandrup Kandemir, SJ Walsh, DR Spring
– Chem Soc Rev
(2020)
50,
39
(doi: 10.1039/d0cs00344a)
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angewandte Chemie
(2020)
132,
23245
(doi: 10.1002/ange.202010090)
Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angewandte Chemie - International Edition
(2020)
59,
23045
(doi: 10.1002/anie.202010090)
Adventures in drugging undruggable targets
DR Spring
– JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2020)
63,
362
(link to publication)
Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin-Resistant Staphylococcus aureus (MRSA)
JJ Freudenreich, S Bartlett, NS Robertson, SL Kidd, S Forrest, HF Sore, WRJD Galloway, M Welch, DR Spring
– ChemMedChem
(2020)
15,
1289
(doi: 10.1002/cmdc.202000179)
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.
DA Russell, HR Bridges, R Serreli, SL Kidd, N Mateu, TJ Osberger, HF Sore, J Hirst, DR Spring
– Journal of Natural Products
(2020)
83,
1829
(doi: 10.1021/acs.jnatprod.9b01224)
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, D Bellini, R Talon, J McLoughlin, T Krojer, A Aimon, A Bradley, M Fairhead, P Brear, L Díaz-Sáez, K McAuley, HF Sore, A Madin, DH O'Donovan, KVM Huber, M Hyvönen, F von Delft, CG Dowson, DR Spring
– Chemical Science
(2020)
11,
10792
(doi: 10.1039/d0sc01232g)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge