Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
RCB Nicolescu, ZR Maylin, FJ Pérez‐Areales, J Iegre, HS Pandha, M Asim, DR Spring
ChemMedChem
(2023)
18
(doi: 10.1002/cmdc.202200703)
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
RCB Nicolescu, ZR Maylin, FJ Pérez-Areales, J Iegre, HS Pandha, M Asim, DR Spring
Chemmedchem
(2022)
18
(doi: 10.1002/cmdc.202200548)
Non-internalising antibody-drug conjugates
N Ashman, JD Bargh, DR Spring
Chemical Society Reviews
(2022)
51
(doi: 10.1039/d2cs00446a)
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
P Brear, C De Fusco, EL Atkinson, J Iegre, NJ Francis-Newton, AR Venkitaraman, M Hyvönen, DR Spring
Rsc Medicinal Chemistry
(2022)
13
(doi: 10.1039/d2md00161f)
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy
AR Hanby, SJ Walsh, AJ Counsell, N Ashman, KT Mortensen, JS Carroll, DR Spring
Chem Commun (Camb)
(2022)
58
(doi: 10.1039/d2cc02515a)
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
Chemical Science
(2022)
13
(doi: 10.1039/d2sc02198f)
Reconstructing the history of helminth prevalence in the UK
H Ryan, PG Flammer, R Nicholson, L Loe, B Reeves, E Allison, C Guy, IL Doriga, T Waldron, D Walker, C Kirchhelle, G Larson, AL Smith
PLoS neglected tropical diseases
(2022)
16
(doi: 10.1371/journal.pntd.0010312)
Development of small cyclic peptides targeting the CK2α/β interface.
EL Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvönen, DR Spring
Chemical Communications
(2022)
58
(doi: 10.1039/d2cc00707j)
A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
S Collins, LV Vliet, F Gielen, M Janeček, SW Valladolid, C Poudel, G Fusco, A De Simone, C Michel, C Kaminski, D Spring, F Hollfelder, GSK Schierle
(2022)
(doi: 10.21203/rs.3.rs-1478521/v1)
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability
SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2022)
58
(doi: 10.1039/d1cc06766d)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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