Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Diversity-oriented synthesis

WRJD Galloway, RJ Spandl, A Bender, GL Thomas, M Diaz-Gavilan, KMG O’Connell, DR Spring

(2012)

39

(doi: 10.1017/cbo9781139021500.007)

Novel Phosphate Derivatives as Scaffolds for the Preparation of Synthetic Phosphoserine-Based Peptides Using the Fmoc/t-Bu Solid-Phase Strategy

D Spring, A Cilibrizzi, A Isidro-Llobet, N Mateu, W Galloway

Synlett

(2011)

2012

290

(doi: 10.1055/s-0031-1290119)

Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Organocuprate Oxidation

D Spring, S Aves, K O’Connell, K Pike

Synlett

(2011)

2012

298

(doi: 10.1055/s-0031-1290116)

Diversity-Oriented Synthesis

KMG O'Connell, WRJD Galloway, BM Ibbeson, A Isidro‐Llobet, CJ O'Connor, DR Spring

(2011)

131

(doi: 10.1002/9781118141649.ch4)

Importance of relative humidity in the oxidative ageing of organic aerosols: Case study of the ozonolysis of maleic acid aerosol

PJ Gallimore, P Achakulwisut, FD Pope, JF Davies, DR Spring, M Kalberer

Atmospheric Chemistry and Physics

(2011)

11

12181

(doi: 10.5194/acp-11-12181-2011)

Palladium-catalysed cross-coupling of organosilicon reagents

HF Sore, WRJD Galloway, DR Spring

Chem Soc Rev

(2011)

41

1845

(doi: 10.1039/c1cs15181a)

PNA to DNA to microarray decoding facilitates ligand discovery.

WRJD Galloway, DR Spring

Cell Chemical Biology

(2011)

18

1209

(doi: 10.1016/j.chembiol.2011.10.002)

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

VM Bolanos-Garcia, T Lischetti, D Matak-Vinković, E Cota, PJ Simpson, DY Chirgadze, DR Spring, CV Robinson, J Nilsson, TL Blundell

Structure (London, England : 1993)

(2011)

19

1691

(doi: 10.1016/j.str.2011.09.017)

Aryl-Aryl Bond Formation by the Fluoride-Free Cross-Coupling of Aryldisiloxanes with Aryl Bromides

CM Boehner, EC Frye, KMG O'Connell, WRJD Galloway, HF Sore, PG Dominguez, D Norton, DG Hulcoop, M Owen, G Turner, C Crawford, H Horsley, DR Spring

Chemistry – A European Journal

(2011)

17

13230

(doi: 10.1002/chem.201102285)

2-Heptyl-4-quinolone, a precursor of the Pseudomonas quinolone signal molecule, modulates swarming motility in Pseudomonas aeruginosa.

D-G Ha, JH Merritt, TH Hampton, JT Hodgkinson, M Janecek, DR Spring, M Welch, GA O'Toole

J Bacteriol

(2011)

193

6770

(doi: 10.1128/jb.05929-11)