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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Chemical genetics
CJ O'Connor, L Laraia, DR Spring
– Chemical Society Reviews
(2011)
40,
4332
(doi: 10.1039/c1cs15053g)
The Serratia LuxR family regulator CarR 39006 activates transcription independently of cognate quorum sensing signals
S Poulter, TM Carlton, DR Spring, GPC Salmond
– Molecular Microbiology
(2011)
80,
1120
(doi: 10.1111/j.1365-2958.2011.07634.x)
Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene.
Z Xu, DR Spring, J Yoon
– Chemistry an Asian Journal
(2011)
6,
2114
(doi: 10.1002/asia.201100120)
The Serratia LuxR family regulator CarR(39006) activates transcription independently of cognate quorum sensing signals
S Poulter, TM Carlton, DR Spring, GPC Salmond
– Molecular Microbiology
(2011)
80,
1120
(doi: 10.1111/j.1365-2958.2011.07634.x)
Diversity-oriented synthesis of macrocyclic peptidomimetics
A Isidro-Llobet, T Murillo, P Bello, A Cilibrizzi, JT Hodgkinson, WRJD Galloway, A Bender, M Welch, DR Spring
– Proceedings of the National Academy of Sciences of the United States of America
(2011)
108,
6793
(doi: 10.1073/pnas.1015267108)
Rational methods for the selection of diverse screening compounds.
DJ Huggins, AR Venkitaraman, DR Spring
– ACS chemical biology
(2011)
6,
208
(doi: 10.1021/cb100420r)
Controlling the contents of microdroplets by exploiting the permeability of PDMS.
J-U Shim, SN Patil, JT Hodgkinson, SD Bowden, DR Spring, M Welch, WTS Huck, F Hollfelder, C Abell
– Lab on a chip
(2011)
11,
1132
(doi: 10.1039/C0LC00615G)
Better leads come from diversity
WRJD Galloway, DR Spring
– NATURE
(2011)
470,
43
(link to publication)
Drug discovery: A question of library design.
PJ Hajduk, WRJD Galloway, DR Spring
– Nature
(2011)
470,
42
(doi: 10.1038/470042a)
Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls.
JL Kenwright, WRJD Galloway, DT Blackwell, A Isidro-Llobet, J Hodgkinson, L Wortmann, SD Bowden, M Welch, DR Spring
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2011)
17,
2981
(doi: 10.1002/chem.201002093)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

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    About the University

    Research at Cambridge