Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics
B Morkunas, WRJD Galloway, M Wright, BM Ibbeson, JT Hodgkinson, KMG O'Connell, N Bartolucci, M Della Valle, M Welch, DR Spring
Org Biomol Chem
(2012)
10
Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
YS Tan, P Śledź, S Lang, CJ Stubbs, DR Spring, C Abell, RB Best
Angewandte Chemie International Edition
(2012)
51
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
WRJD Galloway, JT Hodgkinson, S Bowden, M Welch, DR Spring
Trends in Microbiology
(2012)
20
Palladium-Catalysed Cross-Coupling of Vinyldisiloxanes with Benzylic and Allylic Halides and Sulfonates
EC Frye, CJ O'Connor, DG Twigg, B Elbert, L Laraia, DG Hulcoop, AR Venkitaraman, DR Spring
Chemistry - A European Journal
(2012)
18
Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds
KMG O'Connell, M Díaz-Gavilán, WRJD Galloway, DR Spring
Beilstein Journal of Organic Chemistry
(2012)
8
Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs
JT Hodgkinson, WRJD Galloway, M Welch, DR Spring
Nat Protoc
(2012)
7
The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles.
JWL Lee, V Carrascón, PJ Gallimore, SJ Fuller, A Björkegren, DR Spring, FD Pope, M Kalberer
Physical Chemistry Chemical Physics
(2012)
14
Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa
JT Hodgkinson, WRJD Galloway, M Wright, IK Mati, RL Nicholson, M Welch, DR Spring
Organic and Biomolecular Chemistry
(2012)
10
Diversity-oriented synthesis: Producing chemical tools for dissecting biology
CJ O' Connor, HSG Beckmann, DR Spring
Chem Soc Rev
(2012)
41
Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity
S Zheng, L Laraia, CJ O'Connor, D Sorrell, YS Tan, Z Xu, AR Venkitaraman, W Wu, DR Spring
Organic and Biomolecular Chemistry
(2012)
10

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address