Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Diversity-oriented synthesis: producing chemical tools for dissecting biology
CJ O' Connor, HSG Beckmann, DR Spring
Chemical Society Reviews
(2012)
41
Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity
S Zheng, L Laraia, CJ O'Connor, D Sorrell, YS Tan, Z Xu, AR Venkitaraman, W Wu, DR Spring
Organic and Biomolecular Chemistry
(2012)
10
Coumarin-derived transformable fluorescent sensor for Zn2+
Z Xu, X Liu, J Pan, DR Spring
Chemical communications (Cambridge, England)
(2012)
48
A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives
S Zheng, SJ Aves, L Laraia, WRJD Galloway, KG Pike, W Wu, DR Spring
Chemistry A European Journal
(2012)
18
Diversity-oriented synthesis
WRJD Galloway, RJ Spandl, A Bender, GL Thomas, M Diaz-Gavilan, KMG O’Connell, DR Spring
(2012)
Azide-based macrocyclisation strategies towards functionalised stapled peptides
YH Lau, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
243
Modulating protein-protein interactions with small molecules
CJ O' Connor, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
243
Diversity-oriented synthesis of macrocyclic scaffolds
HSG Beckmann, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
243
Synthesis of highly substituted symmetrical 1,3-dienes via organocuprate oxidation
D Spring, S Aves, K O’Connell, K Pike
Synlett
(2011)
2012
Novel Phosphate Derivatives as Scaffolds for the Preparation of Synthetic Phosphoserine-Based Peptides Using the Fmoc/t-Bu Solid-Phase Strategy
D Spring, A Cilibrizzi, A Isidro-Llobet, N Mateu, W Galloway
Synlett
(2011)
2012

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address