Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Chemical library screening approaches to aid the design of protein-protein inhibitors
L Laraia, DR Spring
(2013)
(doi: 10.4155/EBO.13.151)
Design and synthesis of a biotinylated chemical probe for detecting the molecular targets of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin.
YR Baker, WRJD Galloway, JT Hodgkinson, DR Spring
Molecules
(2013)
18
(doi: 10.3390/molecules181011783)
Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing.
SD Bowden, N Hale, JCS Chung, JT Hodgkinson, DR Spring, M Welch
Microbiology
(2013)
159
(doi: 10.1099/mic.0.070748-0)
A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling
HSG Beckmann, F Nie, CE Hagerman, H Johansson, YS Tan, D Wilcke, DR Spring
Nat Chem
(2013)
5
(doi: 10.1038/NCHEM.1729)
The Basics of Diversity‐Oriented Synthesis
KMG O'Connell, WRJD Galloway, DR Spring
(2013)
(doi: 10.1002/9781118618110.ch1)
Ligand Binding Kinetics of the Quorum Sensing Regulator PqsR
M Welch, JT Hodgkinson, J Gross, DR Spring, T Sams
Biochemistry
(2013)
52
(doi: 10.1021/bi400315s)
A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells
T Liu, Z Xu, DR Spring, J Cui
Organic letters
(2013)
15
(doi: 10.1021/ol400973v)
Hydrosilylation in water: A new bioorthogonal reaction?
EC Frye, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245
Design, synthesis, and biological evaluation of Polo-box domain (PBD) phosphopeptidomimetics
JE Stokes, A Emery, B Hardwick, AJ Narvaez, E Alza, J Balmer, G McKenzie, DR Spring, A Venkitaraman
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245
Diversity-oriented synthesis and phenotypic screening identifies novel small molecule regulators of mitosis
L Laraia, AR Venkitaraman, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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