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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
WRJD Galloway, JT Hodgkinson, S Bowden, M Welch, DR Spring
– Trends in Microbiology
(2012)
20,
449
(doi: 10.1016/j.tim.2012.06.003)
Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates
EC Frye, CJ O'Connor, DG Twigg, B Elbert, L Laraia, DG Hulcoop, AR Venkitaraman, DR Spring
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2012)
18,
8774
(doi: 10.1002/chem.201200431)
Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds
KMG O'Connell, M Díaz-Gavilán, WRJD Galloway, DR Spring
– Beilstein J Org Chem
(2012)
8,
850
(doi: 10.3762/bjoc.8.95)
Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs
JT Hodgkinson, WRJD Galloway, M Welch, DR Spring
– Nature Protocols
(2012)
7,
1184
(doi: 10.1038/nprot.2012.054)
The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles.
JWL Lee, V Carrascón, PJ Gallimore, SJ Fuller, A Björkegren, DR Spring, FD Pope, M Kalberer
– Phys Chem Chem Phys
(2012)
14,
8023
(doi: 10.1039/c2cp24094g)
Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa
JT Hodgkinson, WRJD Galloway, M Wright, IK Mati, RL Nicholson, M Welch, DR Spring
– Organic & Biomolecular Chemistry
(2012)
10,
6032
(doi: 10.1039/c2ob25198a)
Diversity-oriented synthesis: producing chemical tools for dissecting biology
CJ O' Connor, HSG Beckmann, DR Spring
– Chemical Society reviews
(2012)
41,
4444
(doi: 10.1039/c2cs35023h)
Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity
S Zheng, L Laraia, CJ O'Connor, D Sorrell, YS Tan, Z Xu, AR Venkitaraman, W Wu, DR Spring
– Organic and Biomolecular Chemistry
(2012)
10,
2590
(doi: 10.1039/c2ob25065a)
Coumarin-derived transformable fluorescent sensor for Zn2+.
Z Xu, X Liu, J Pan, DR Spring
– Chem Commun (Camb)
(2012)
48,
4764
(doi: 10.1039/c2cc30963g)
A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives
S Zheng, SJ Aves, L Laraia, WRJD Galloway, KG Pike, W Wu, DR Spring
– Chemistry A European Journal
(2012)
18,
3193
(doi: 10.1002/chem.201103530)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

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    About the University

    Research at Cambridge