Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Hydrosilylation in water: A new bioorthogonal reaction?
EC Frye, DR Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide
P Sledz, M Hyvonen, YS Tan, S Lang, D Spring, C Abell, RB Best
(2012)
(doi: 10.2210/pdb4e67/pdb)
A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds
KMG O'Connell, HSG Beckmann, L Laraia, HT Horsley, A Bender, AR Venkitaraman, DR Spring
Organic & Biomolecular Chemistry
(2012)
10
(doi: 10.1039/c2ob26272j)
Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics
B Morkunas, WRJD Galloway, M Wright, BM Ibbeson, JT Hodgkinson, KMG O'Connell, N Bartolucci, M Della Valle, M Welch, DR Spring
Organic and Biomolecular Chemistry
(2012)
10
(doi: 10.1039/c2ob26501j)
Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1
YS Tan, P Śledź, S Lang, CJ Stubbs, DR Spring, C Abell, RB Best
Angewandte Chemie (International ed. in English)
(2012)
51
(doi: 10.1002/anie.201205676)
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
WRJD Galloway, JT Hodgkinson, S Bowden, M Welch, DR Spring
Trends in Microbiology
(2012)
20
(doi: 10.1016/j.tim.2012.06.003)
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
WRJD Galloway, JT Hodgkinson, S Bowden, M Welch, DR Spring
Trends Microbiol
(2012)
20
(doi: 10.1016/j.tim.2012.06.003)
Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates
EC Frye, CJ O'Connor, DG Twigg, B Elbert, L Laraia, DG Hulcoop, AR Venkitaraman, DR Spring
Chemistry - A European Journal
(2012)
18
(doi: 10.1002/chem.201200431)
Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds.
KMG O'Connell, M Díaz-Gavilán, WRJD Galloway, DR Spring
Beilstein J Org Chem
(2012)
8
(doi: 10.3762/bjoc.8.95)
Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1h)-quinolone and structurally related analogs
JT Hodgkinson, WRJD Galloway, M Welch, DR Spring
Nature protocols
(2012)
7
(doi: 10.1038/nprot.2012.054)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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