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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections
TM Postma, WRJD Galloway, FBL Cougnon, GD Pantoş, JE Stokes, DR Spring
– Synlett
(2013)
24,
765
(doi: 10.1055/s-0032-1318407)
Hydrosilylation in water: A new bioorthogonal reaction?
EC Frye, DR Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
(link to publication)
Design, synthesis, and biological evaluation of Polo-box domain (PBD) phosphopeptidomimetics
JE Stokes, A Emery, B Hardwick, AJ Narvaez, E Alza, J Balmer, G McKenzie, DR Spring, A Venkitaraman
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
(link to publication)
Investigations into the Ullmann biaryl ether synthesis
MJ Scott, JS Parker, DR Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
(link to publication)
Diversity-oriented synthesis and phenotypic screening identifies novel small molecule regulators of mitosis
L Laraia, AR Venkitaraman, DR Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
(link to publication)
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide
P Sledz, M Hyvonen, YS Tan, S Lang, D Spring, C Abell, RB Best
(2012)
(doi: 10.2210/pdb4e67/pdb)
A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.
KMG O'Connell, HSG Beckmann, L Laraia, HT Horsley, A Bender, AR Venkitaraman, DR Spring
– Organic & biomolecular chemistry
(2012)
10,
7545
(doi: 10.1039/c2ob26272j)
Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics
B Morkunas, WRJD Galloway, M Wright, BM Ibbeson, JT Hodgkinson, KMG O'Connell, N Bartolucci, M Della Valle, M Welch, DR Spring
– Org Biomol Chem
(2012)
10,
8452
(doi: 10.1039/c2ob26501j)
Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1
YS Tan, P Śledź, S Lang, CJ Stubbs, DR Spring, C Abell, RB Best
– Angewandte Chemie International Edition
(2012)
51,
10078
(doi: 10.1002/anie.201205676)
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
WRJD Galloway, JT Hodgkinson, S Bowden, M Welch, DR Spring
– Trends in Microbiology
(2012)
20,
449
(doi: 10.1016/j.tim.2012.06.003)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge