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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Chemical library screening approaches to aid the design of protein–protein inhibitors
L Laraia, DR Spring
(2013)
32
(doi: 10.4155/EBO.13.151)
Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp
SD Bowden, A Eyres, JCS Chung, RE Monson, A Thompson, GPC Salmond, DR Spring, M Welch
– Mol Microbiol
(2013)
90,
457
(doi: 10.1111/mmi.12369)
Design and synthesis of a biotinylated chemical probe for detecting the molecular targets of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin.
YR Baker, WRJD Galloway, JT Hodgkinson, DR Spring
– Molecules
(2013)
18,
11783
(doi: 10.3390/molecules181011783)
Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing.
SD Bowden, N Hale, JCS Chung, JT Hodgkinson, DR Spring, M Welch
– Microbiology United Kingdom
(2013)
159,
2375
(doi: 10.1099/mic.0.070748-0)
Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
KMG O'Connell, JT Hodgkinson, HF Sore, M Welch, GPC Salmond, DR Spring
– Angew Chem Int Ed Engl
(2013)
52,
10706
(doi: 10.1002/anie.201209979)
A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.
HSG Beckmann, F Nie, CE Hagerman, H Johansson, YS Tan, D Wilcke, DR Spring
– Nat Chem
(2013)
5,
861
(doi: 10.1038/nchem.1729)
Ligand Binding Kinetics of the Quorum Sensing Regulator PqsR
M Welch, JT Hodgkinson, J Gross, DR Spring, T Sams
– Biochemistry
(2013)
52,
4433
(doi: 10.1021/bi400315s)
A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells
T Liu, Z Xu, DR Spring, J Cui
– Organic Letters
(2013)
15,
2310
(doi: 10.1021/ol400973v)
Mild and efficient synthesis of benzo-fused seven- and eight-membered ring lactams: A convenient approach to biologically interesting chemotypes
JL Kenwright, WRJD Galloway, L Wortmann, DR Spring
– Synthetic Communications
(2013)
43,
1508
(doi: 10.1080/00397911.2011.643439)
Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections
TM Postma, WRJD Galloway, FBL Cougnon, GD Pantoş, JE Stokes, DR Spring
– Synlett
(2013)
24,
765
(doi: 10.1055/s-0032-1318407)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge