Professor David Spring | Page 24 | Yusuf Hamied Department of Chemistry

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Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Functionalised staple linkages for modulating the cellular activity of stapled peptides

YH Lau, P de Andrade, ST Quah, M Rossmann, L Laraia, N Sköld, TJ Sum, PJE Rowling, TL Joseph, C Verma, M Hyvönen, LS Itzhaki, AR Venkitaraman, CJ Brown, DP Lane, DR Spring

– Chemical Science

(2014)

5,

1804

(doi: 10.1039/c4sc00045e)

Chemical probes for studying cell-to-cell communication in bacteria

YR Baker, JT Hodgkinson, M Welch, DR Spring

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)

Development of small-molecule inhibitors of Aurora kinase A: TPX2 protein-protein interaction

M Janecek, P Sharma, M Rossmann, G McKenzie, M Hyvoenen, DR Spring, AR Venkitaraman

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)

Unusual Z-selectivity in the Takai olefination: Evidence for a competing chelation reaction mechanism

CE Hagerman, SM Geddis, DR Spring

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)

Targeting mitochondria in prostate cancer with the rotenoid group of natural products

DA Russell, DR Spring, DE Neal, LG Fryer

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)

How Diverse Are Diversity Assessment Methods? A Comparative Analysis and Benchmarking of Molecular Descriptor Space.

A Koutsoukas, S Paricharak, WRJD Galloway, DR Spring, AP Ijzerman, RC Glen, D Marcus, A Bender

– Journal of chemical information and modeling

(2013)

54,

230

(doi: 10.1021/ci400469u)

Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp

SD Bowden, A Eyres, JCS Chung, RE Monson, A Thompson, GPC Salmond, DR Spring, M Welch

– Molecular Microbiology

(2013)

90,

457

(doi: 10.1111/mmi.12369)

Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems.

P Mestichelli, MJ Scott, WRJD Galloway, J Selwyn, JS Parker, DR Spring

– Organic Letters

(2013)

15,

5448

(doi: 10.1021/ol4025259)

Combating multidrug-resistant bacteria: Current strategies for the discovery of novel antibacterials

KMG O'Connell, JT Hodgkinson, HF Sore, M Welch, GPC Salmond, DR Spring

– Angewandte Chemie International Edition

(2013)

52,

10706

(doi: 10.1002/anie.201209979)

Chemical library screening approaches to aid the design of protein–protein inhibitors

G Zinzalla, L Laraia, DR Spring

(2013)

32

(doi: 10.4155/ebo.13.151)