Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
MS Frei, MK Bilyard, TA Alanine, WRJD Galloway, JE Stokes, DR Spring
Bioorganic and Medicinal Chemistry
(2015)
23
(doi: 10.1016/j.bmc.2014.11.037)
Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha
TH Sum, TJ Sum, JE Stokes, WRJD Galloway, DR Spring
Tetrahedron
(2015)
71
(doi: 10.1016/j.tet.2015.02.017)
The Pseudomonas Quinolone Signal (PQS)
T Sams, Y Baker, J Hodgkinson, J Gross, D Spring, M Welch
Israel Journal of Chemistry
(2015)
56
(doi: 10.1002/ijch.201400128)
Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction.
RJH Scanes, O Grossmann, A Grossmann, DR Spring
Organic Letters
(2015)
17
(doi: 10.1021/acs.orglett.5b00971)
A two-component 'double-click' approach to peptide stapling
YH Lau, Y Wu, P de Andrade, WRJD Galloway, DR Spring
Nat Protoc
(2015)
10
(doi: 10.1038/nprot.2015.033)
A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds
A Isidro-Llobet, K Hadje Georgiou, WRJD Galloway, E Giacomini, MR Hansen, G Méndez-Abt, YS Tan, L Carro, HF Sore, DR Spring
Organic and Biomolecular Chemistry
(2015)
13
(doi: 10.1039/c5ob00371g)
Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation
Z Walsh, E-R Janeček, JT Hodgkinson, J Sedlmair, A Koutsioubas, DR Spring, M Welch, CJ Hirschmugl, C Toprakcioglu, JR Nitschke, M Jones, OA Scherman
Proceedings of the National Academy of Sciences
(2014)
111
(doi: 10.1073/pnas.1406037111)
Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides
YH Lau, P de Andrade, GJ McKenzie, AR Venkitaraman, DR Spring
ChemBioChem
(2014)
15
(doi: 10.1002/cbic.201402374)
Diversity‐Oriented Synthesis of Drug‐Like Macrocyclic Scaffolds Using an Orthogonal Organo‐ and Metal Catalysis Strategy
A Grossmann, S Bartlett, M Janecek, JT Hodgkinson, DR Spring
Angewandte Chemie (International ed. in English)
(2014)
53
(doi: 10.1002/anie.201406865)
Synthesis of a novel polycyclic ring scaffold with antimitotic properties
E Alza, L Laraia, BM Ibbeson, S Collins, WRJD Galloway, JE Stokes, AR Venkitaraman, DR Spring
Chemical Science
(2014)
6
(doi: 10.1039/c4sc02547d)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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