Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides

YH Lau, P de Andrade, GJ McKenzie, AR Venkitaraman, DR Spring

Chembiochem : a European journal of chemical biology

(2014)

15

2680

(doi: 10.1002/cbic.201402374)

Diversity‐Oriented Synthesis of Drug‐Like Macrocyclic Scaffolds Using an Orthogonal Organo‐ and Metal Catalysis Strategy

A Grossmann, S Bartlett, M Janecek, JT Hodgkinson, DR Spring

Angew Chem Int Ed Engl

(2014)

53

13093

(doi: 10.1002/anie.201406865)

Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck–Suzuki reaction

E Alza, L Laraia, BM Ibbeson, S Collins, WRJD Galloway, JE Stokes, AR Venkitaraman, DR Spring

Chemical Science

(2014)

6

390

(doi: 10.1039/c4sc02547d)

Peptide stapling techniques based on different macrocyclisation chemistries

YH Lau, P de Andrade, Y Wu, DR Spring

Chem Soc Rev

(2014)

44

91

(doi: 10.1039/c4cs00246f)

Concise synthesis of substituted quinolizin-4-ones by ring-closing metathesis

TA Alanine, WRJD Galloway, TM McGuire, DR Spring

European Journal of Organic Chemistry

(2014)

2014

5767

(doi: 10.1002/ejoc.201402648)

Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems

WRJD Galloway, D Wilcke, F Nie, K Hadje‐Georgiou, L Laraia, DR Spring

(2014)

9783527336111

379

(doi: 10.1002/9783527687503.ch26)

Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae.

SW Wachira, S Omar, JW Jacob, M Wahome, HT Alborn, DR Spring, DK Masiga, B Torto

Parasites & vectors

(2014)

7

312

(doi: 10.1186/1756-3305-7-312)

Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy

F Zhang, DR Spring

Chem. Soc. Rev.

(2014)

43

6906

(doi: 10.1039/c4cs00137k)

Quantitatively mapping cellular viscosity with detailed organelle information via a designed PET fluorescent probe.

T Liu, X Liu, DR Spring, X Qian, J Cui, Z Xu

Sci Rep

(2014)

4

5418

(doi: 10.1038/srep05418)

The use of chlorobenzene as a probe molecule in molecular dynamics simulations

YS Tan, DR Spring, C Abell, C Verma

J. Chem. Inf. Model.

(2014)

54

1821

(doi: 10.1021/ci500215x)