Professor David Spring | Page 23 | Yusuf Hamied Department of Chemistry

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Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Quantitatively mapping cellular viscosity with detailed organelle information via a designed PET fluorescent probe

T Liu, X Liu, DR Spring, X Qian, J Cui, Z Xu

– Sci Rep

(2014)

4,

5418

(doi: 10.1038/srep05418)

The use of chlorobenzene as a probe molecule in molecular dynamics simulations.

YS Tan, DR Spring, C Abell, C Verma

– Journal of chemical information and modeling

(2014)

54,

1821

(doi: 10.1021/ci500215x)

Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2

KL Irvine, M Gangloff, CM Walsh, DR Spring, NJ Gay, CE Bryant

– PLoS ONE

(2014)

9,

e98776

(doi: 10.1371/journal.pone.0098776)

High Content Screening of Diverse Compound Libraries Identifies Potent Modulators of Tubulin Dynamics

L Laraia, J Stokes, A Emery, GJ McKenzie, AR Venkitaraman, DR Spring

– ACS Medicinal Chemistry Letters

(2014)

5,

598

(doi: 10.1021/ml5000564)

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis.

BM Ibbeson, L Laraia, E Alza, CJ O' Connor, YS Tan, HML Davies, G McKenzie, AR Venkitaraman, DR Spring

– Nat Commun

(2014)

5,

3155

(doi: 10.1038/ncomms4155)

Aqeuous hydrosilylation: Application to site-selective protein modification

TT-L Kwan, EC Frye, MK Gupta, M Welch, JW Chin, DR Spring

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)

Targeting mitochondria in prostate cancer with the rotenoid group of natural products

DA Russell, DR Spring, DE Neal, LG Fryer

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)

Small molecule modulation of quorum sensing pathways

DR Spring

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

247,

(link to publication)

Chemical probes for studying cell-to-cell communication in bacteria

YR Baker, JT Hodgkinson, M Welch, DR Spring

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)

Unusual Z-selectivity in the Takai olefination: Evidence for a competing chelation reaction mechanism

CE Hagerman, SM Geddis, DR Spring

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

248,

(link to publication)