Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Divergent synthesis of six biologically active 4-quinolone natural products isolated from Pseudonocardia sp CL38489
S Geddis, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
252
The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
F Salvaggio, JT Hodgkinson, L Carro, SM Geddis, WRJD Galloway, M Welch, DR Spring
European Journal of Organic Chemistry
(2015)
2016
(doi: 10.1002/ejoc.201501400)
Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.
TA Alanine, WRJD Galloway, S Bartlett, JJ Ciardiello, TM McGuire, DR Spring
Organic & Biomolecular Chemistry
(2015)
14
(doi: 10.1039/c5ob01784j)
Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.
YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring
Angew Chem Int Ed Engl
(2015)
54
(doi: 10.1002/anie.201508416)
Double Strain‐Promoted Macrocyclization for the Rapid Selection of Cell‐Active Stapled Peptides
YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring
Angewandte Chemie
(2015)
127
(doi: 10.1002/ange.201508416)
Which microbial factors really are important in Pseudomonas aeruginosa infections?
A Crousilles, E Maunders, S Bartlett, C Fan, E-F Ukor, Y Abdelhamid, Y Baker, A Floto, DR Spring, M Welch
Future Microbiol
(2015)
10
(doi: 10.2217/fmb.15.100)
New Advances in Diversity‐Oriented Synthesis
WRJD Galloway, JE Stokes, DR Spring
(2015)
(doi: 10.1002/9781118771723.ch4)
The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions.
YS Tan, DR Spring, C Abell, CS Verma
Journal of Chemical Theory and Computation
(2015)
11
(doi: 10.1021/ct5010577)
Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
L Laraia, G McKenzie, DR Spring, AR Venkitaraman, DJ Huggins
Chemistry & Biology
(2015)
22
(doi: 10.1016/j.chembiol.2015.04.019)
Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
MS Frei, MK Bilyard, TA Alanine, WRJD Galloway, JE Stokes, DR Spring
Bioorganic and Medicinal Chemistry
(2015)
23
(doi: 10.1016/j.bmc.2014.11.037)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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