Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Multiple‐parameter Optimization in Drug Discovery: Example of the 5‐HT1B GPCR
RC Glen, WRJD Galloway, DR Spring, G Liwiki
Molecular informatics
(2016)
35
(doi: 10.1002/minf.201600056)
The reductive cleavage of picolinic amides
DHO Donovan, C De Fusco, DR Spring
Tetrahedron Letters
(2016)
57
(doi: 10.1016/j.tetlet.2016.05.068)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(doi: 10.2210/pdb5bxo/pdb)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(doi: 10.2210/pdb5bxu/pdb)
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, JE Stokes, YS Tan, EG Almeida, B Hardwick, AJ Narvaez, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
Scientific reports
(2016)
6
(doi: 10.1038/srep28528)
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
MM Wiedmann, S Aibara, DR Spring, M Stewart, JD Brenton
J Struct Biol
(2016)
195
(doi: 10.1016/j.jsb.2016.06.018)
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.
A Chattopadhyay, CJ O'Connor, F Zhang, C Galvagnion, WRJD Galloway, YS Tan, JE Stokes, T Rahman, C Verma, DR Spring, LS Itzhaki
Sci Rep
(2016)
6
(doi: 10.1038/srep23732)
Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology
D Spring, S Collins, S Bartlett, F Nie, H Sore
Synthesis Germany
(2016)
48
(doi: 10.1055/s-0035-1561414)
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling
Y Wu, LB Olsen, YH Lau, CH Jensen, M Rossmann, YR Baker, HF Sore, S Collins, DR Spring
Chembiochem : a European journal of chemical biology
(2016)
17
(doi: 10.1002/cbic.201500648)
Targeting transcription factor HNF1β in ovarian cancer using stapled peptides
M Wiedmann, D Spring, J Brenton
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
251

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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