Professor David Spring | Yusuf Hamied Department of Chemistry

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring

Angew Chem Int Ed Engl

(2015)

54

15410

(doi: 10.1002/anie.201508416)

Which microbial factors really are important in Pseudomonas aeruginosa infections?

A Crousilles, E Maunders, S Bartlett, C Fan, E-F Ukor, Y Abdelhamid, Y Baker, A Floto, DR Spring, M Welch

Future Microbiol

(2015)

10

1825

(doi: 10.2217/fmb.15.100)

New Advances in Diversity‐Oriented Synthesis

WRJD Galloway, JE Stokes, DR Spring

(2015)

77

(doi: 10.1002/9781118771723.ch4)

The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions.

YS Tan, DR Spring, C Abell, CS Verma

J Chem Theory Comput

(2015)

11

3199

(doi: 10.1021/ct5010577)

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

L Laraia, G McKenzie, DR Spring, AR Venkitaraman, DJ Huggins

Chem Biol

(2015)

22

689

(doi: 10.1016/j.chembiol.2015.04.019)

Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis

MS Frei, MK Bilyard, TA Alanine, WRJD Galloway, JE Stokes, DR Spring

Bioorganic and Medicinal Chemistry

(2015)

23

2666

(doi: 10.1016/j.bmc.2014.11.037)

Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha

TH Sum, TJ Sum, JE Stokes, WRJD Galloway, DR Spring

Tetrahedron

(2015)

71

4557

(doi: 10.1016/j.tet.2015.02.017)

The Pseudomonas Quinolone Signal (PQS)

T Sams, Y Baker, J Hodgkinson, J Gross, D Spring, M Welch

Israel Journal of Chemistry

(2015)

56

282

(doi: 10.1002/ijch.201400128)

Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction.

RJH Scanes, O Grossmann, A Grossmann, DR Spring

Organic Letters

(2015)

17

2462

(doi: 10.1021/acs.orglett.5b00971)

A two-component 'double-click' approach to peptide stapling

YH Lau, Y Wu, P de Andrade, WRJD Galloway, DR Spring

Nature protocols

(2015)

10

585

(doi: 10.1038/nprot.2015.033)