Yusuf Hamied Department of Chemistry

Professor David Spring

Professor of Chemistry & Chemical Biology

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Targeting transcription factor HNF1β in ovarian cancer using stapled peptides
M Wiedmann, D Spring, J Brenton
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
251
Synthesis of diverse semi-saturated bicyclic heteroaromatics
H Stewart, D Spring, T Moss
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
252
The reductive cleavage of picolinic amides
DHO Donovan, C De Fusco, DR Spring
Tetrahedron Letters
(2016)
57
(doi: 10.1016/j.tetlet.2016.05.068)
The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
F Salvaggio, JT Hodgkinson, L Carro, SM Geddis, WRJD Galloway, M Welch, DR Spring
European Journal of Organic Chemistry
(2015)
2016
(doi: 10.1002/ejoc.201501400)
Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen
TA Alanine, WRJD Galloway, S Bartlett, JJ Ciardiello, TM McGuire, DR Spring
Organic & biomolecular chemistry
(2015)
14
(doi: 10.1039/c5ob01784j)
Double Strain‐Promoted Macrocyclization for the Rapid Selection of Cell‐Active Stapled Peptides
YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring
Angewandte Chemie
(2015)
127
(doi: 10.1002/ange.201508416)
Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides
YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring
Angewandte Chemie International Edition
(2015)
54
(doi: 10.1002/anie.201508416)
Which microbial factors really are important in Pseudomonas aeruginosa infections?
A Crousilles, E Maunders, S Bartlett, C Fan, E-F Ukor, Y Abdelhamid, Y Baker, A Floto, DR Spring, M Welch
Future Microbiol
(2015)
10
(doi: 10.2217/fmb.15.100)
New Advances in Diversity-Oriented Synthesis
WRJD Galloway, JE Stokes, DR Spring
(2015)
(doi: 10.1002/9781118771723.ch4)
The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions
YS Tan, DR Spring, C Abell, CS Verma
J Chem Theory Comput
(2015)
11
(doi: 10.1021/ct5010577)

Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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