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Yusuf Hamied Department of Chemistry

 

Publications by Professor Gonçalo Bernardes

Computational advances in combating colloidal aggregation in drug discovery
D Reker, GJL Bernardes, T Rodrigues
– Nat Chem
(2019)
11,
402
(DOI: 10.1038/s41557-019-0234-9)
Potassium Arylethynyltrifluoroborate as an Unstrained Dienophile for Ultrafast and On Demand Activation of Bioorthogonal IEDDA Reactions
Z Guo, B Oliveira, C Navo, P M. S. D. Cal, F Corzana, G Jiménez-Osés, G Bernardes
(2019)
(DOI: 10.26434/chemrxiv.8038685.v1)
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez‐Osés, GJL Bernardes
– Angewandte Chemie
(2019)
131,
6712
(DOI: 10.1002/ange.201901405)
Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs
AL Amorim, MM Peterle, A Guerreiro, DF Coimbra, RS Heying, GF Caramori, AL Braga, AJ Bortoluzzi, A Neves, GJL Bernardes, R Peralta
– Dalton Trans
(2019)
48,
5574
(DOI: 10.1039/c9dt00616h)
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells
LJ Alcock, BL Oliveira, MJ Deery, TL Pukala, MV Perkins, GJL Bernardes, JM Chalker
– ACS Chem Biol
(2019)
14,
594
(DOI: 10.1021/acschembio.8b01104)
Azabicyclic vinyl sulfones for residue-specific dual protein labelling.
E Gil de Montes, E Jiménez-Moreno, BL Oliveira, CD Navo, PMSD Cal, G Jiménez-Osés, I Robina, AJ Moreno-Vargas, GJL Bernardes
– Chemical science
(2019)
10,
4515
(DOI: 10.1039/c9sc00125e)
Natural product-drug conjugates for modulation of TRPV1-expressing tumors
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
– Bioorganic & Medicinal Chemistry
(2019)
27,
2531
(DOI: 10.1016/j.bmc.2019.03.025)
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
P Akkapeddi, R Fragoso, JA Hixon, AS Ramalho, ML Oliveira, T Carvalho, A Gloger, M Matasci, F Corzana, SK Durum, D Neri, GJL Bernardes, JT Barata
– Leukemia
(2019)
33,
2155
(DOI: 10.1038/s41375-019-0434-8)
A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism
VE Zwicker, BL Oliveira, JH Yeo, ST Fraser, GJL Bernardes, EJ New, KA Jolliffe
– Angewandte Chemie
(2019)
131,
3119
(DOI: 10.1002/ange.201812489)
Contemporary approaches to site-selective protein modification
EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes
– Nature Reviews Chemistry
(2019)
3,
147
(DOI: 10.1038/s41570-019-0079-1)
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana
– Journal of the American Chemical Society
(2019)
141,
4063
(DOI: 10.1021/jacs.8b13503)
De novo design of potent and selective mimics of IL-2 and IL-15.
D-A Silva, S Yu, UY Ulge, JB Spangler, KM Jude, C Labão-Almeida, LR Ali, A Quijano-Rubio, M Ruterbusch, I Leung, T Biary, SJ Crowley, E Marcos, CD Walkey, BD Weitzner, F Pardo-Avila, J Castellanos, L Carter, L Stewart, SR Riddell, M Pepper, GJL Bernardes, M Dougan, KC Garcia, D Baker
– Nature
(2019)
565,
186
(DOI: 10.1038/s41586-018-0830-7)
Lysine Bioconjugation on Native Albumin with a Sulfonyl Acrylate Reagent.
MJ Matos, G Jiménez-Osés, GJL Bernardes
– Methods Mol Biol
(2019)
2033,
25
(DOI: 10.1007/978-1-4939-9654-4_3)
Efficient and irreversible antibody-cysteine bioconjugation using carbonylacrylic reagents.
B Bernardim, MJ Matos, X Ferhati, I Compañón, A Guerreiro, P Akkapeddi, ACB Burtoloso, G Jiménez-Osés, F Corzana, GJL Bernardes
– Nat Protoc
(2019)
14,
86
(DOI: 10.1038/s41596-018-0083-9)
One-pot stapling of interchain disulfides of antibodies using an isobutylene motif.
S Sun, P Akkapeddi, MC Marques, N Martínez-Sáez, VM Torres, C Cordeiro, O Boutureira, GJL Bernardes
– Org Biomol Chem
(2018)
17,
2005
(DOI: 10.1039/c8ob02877j)
Protein engineering through chemical, genetic and computational manipulation.
I Hamachi, GJL Bernardes
– Chemical Society Reviews
(2018)
47,
8977
(DOI: 10.1039/c8cs90125b)
Bioorthogonal decaging reactions for targeted drug activation
S Davies, BJ Stenton, GJL Bernardes
– Chimia
(2018)
72,
771
(DOI: 10.2533/chimia.2018.771)
Radical‐Mediated Thiol‐Ene Strategy: Photoactivation of Thiol‐Containing Drugs in Cancer Cells
GJ Lopes Bernardes
– Angewandte Chemie (International ed. in English)
(2018)
57,
15832
(DOI: 10.1002/anie.201811338)
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution
NL Mutter, M Soskine, G Huang, IS Albuquerque, GJL Bernardes, G Maglia
– ACS Chem Biol
(2018)
13,
3153
(DOI: 10.1021/acschembio.8b00720)
Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo
B Stenton, B Oliveira, J Conde, M Negrão, M Godinho Ferreira, R Fior, G Bernardes
(2018)
(DOI: 10.26434/chemrxiv.7327904.v1)

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