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Yusuf Hamied Department of Chemistry

 

Publications by Professor David Spring

A Platform for SpyCatcher Conjugation to Native Antibodies
S Krajcovicova, T Wharton, CL Driscoll, TA King, MR Howarth, DR Spring
– Chemical Science
(2025)
(DOI: 10.1039/d5sc02286j)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2025)
(DOI: 10.7554/elife.104238)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2025)
(DOI: 10.7554/elife.104238.2)
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
T Wharton, DR Spring
– ChemMedChem
(2025)
20,
e202500132
(DOI: 10.1002/cmdc.202500132)
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity
M Wang, P Medarametla, T Kronenberger, T Deingruber, P Brear, W Figueroa, P-M Ho, T Krueger, JC Pearce, A Poso, JG Wakefield, DR Spring, M Welch
– Nat Commun
(2025)
16,
2334
(DOI: 10.1038/s41467-025-57532-z)
Pseudomonas aeruginosa PfpI is a methylglyoxalase.
L Grimm, A Wijaya, I Askenasy, RR Nazeer, H Seki, PD Brear, W Figueroa, DR Spring, M Welch
– The Journal of biological chemistry
(2025)
301,
108374
(DOI: 10.1016/j.jbc.2025.108374)
The 2-methylcitrate cycle and the glyoxylate shunt in Pseudomonas aeruginosa are linked through enzymatic redundancy
AJ Wijaya, SK Dolan, M Kohlstedt, L Gläser, P Brear, S Geddis, C Wittmann, DR Spring, M Welch
– Journal of Biological Chemistry
(2025)
301,
108355
(DOI: 10.1016/j.jbc.2025.108355)
Advances in the Release of Amide-Containing Molecules
T Wharton, DR Spring
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2025)
31,
e202404413
(DOI: 10.1002/chem.202404413)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, E McCall, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2025)
(DOI: 10.7554/elife.104238.1)
Publisher Correction: Novel immunotherapeutics against LGR5 to target multiple cancer types.
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Ghodsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
– EMBO molecular medicine
(2024)
16,
3026
(DOI: 10.1038/s44321-024-00139-6)
Selective Aurora A-TPX2 interaction inhibitors have in vivo efficacy as targeted anti-mitotic agents
SR Stockwell, DE Scott, G Fischer, E Guarino, TPC Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, TR Perrior, TL Blundell, DR Spring, G McKenzie, C Abell, J Skidmore, AR Venkitaraman, M Hyvönen
– J Med Chem
(2024)
67,
15521
(DOI: 10.1021/acs.jmedchem.4c01165)
Novel immunotherapeutics against LGR5 to target multiple cancer types
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Ghodsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
– EMBO Molecular Medicine
(2024)
16,
2233
(DOI: 10.1038/s44321-024-00121-2)
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs
R Walther, M Park, N Ashman, M Welch, JS Carroll, DR Spring
– Chem Commun (Camb)
(2024)
60,
7025
(DOI: 10.1039/d4cc01558d)
Towards the Targeted Protein Degradation of PRMT1.
PL Martin, FJ Pérez-Areales, SV Rao, SJ Walsh, JS Carroll, DR Spring
– ChemMedChem
(2024)
19,
e202400269
(DOI: 10.1002/cmdc.202400269)
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules.
BM da S Santos, FG Finelli, DR Spring
– Organic letters
(2024)
26,
4065
(DOI: 10.1021/acs.orglett.4c01019)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, E Fisher, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, L Itzhaki
(2024)
(DOI: 10.1101/2024.04.30.590460)
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay-Williams, T Schober, RA Floto, DR Spring
– Angew Chem Int Ed Engl
(2024)
63,
e202402267
(DOI: 10.1002/anie.202402267)
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay‐Williams, T Schober, RA Floto, DR Spring
– Angewandte Chemie
(2024)
136,
e202402267
(DOI: 10.1002/ange.202402267)
CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
S Day-Riley, RM West, PD Brear, M Hyvönen, DR Spring
– Kinases and Phosphatases
(2024)
2,
110
(DOI: 10.3390/kinasesphosphatases2020007)
Site-selective peptide functionalisation mediated via vinyl-triazine linchpins †
JD Sydenham, H Seki, S Krajcovicova, L Zeng, T Schober, T Deingruber, DR Spring
– Chemical Communications
(2024)
60,
706
(DOI: 10.1039/d3cc05213c)

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