Tumor suppressor p53 slides on DNA with low friction and high stability.
A Tafvizi, F Huang, JS Leith, AR Fersht, LA Mirny, AM van Oijen
Biophys J
(2008)
95
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain
M Wells, H Tidow, TJ Rutherford, P Markwick, MR Jensen, E Mylonas, DI Svergun, M Blackledge, AR Fersht
Proc Natl Acad Sci U S A
(2008)
105
High temperature unfolding simulations of the TRPZ1 peptide.
G Settanni, AR Fersht
Biophysical Journal
(2008)
94
A Guide to Measuring and Interpreting Φ‐values
NR Guydosh, AR Fersht
(2008)
1
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.
DB Veprintsev, AR Fersht
Nucleic Acids Research
(2008)
36
Fluorescence resonance energy transfer analysis of the folding pathway of Engrailed Homeodomain
F Huang, G Settanni, AR Fersht
Protein engineering, design & selection : PEDS
(2008)
21
Demonstration by burst-phase analysis of a robust folding intermediate in the FF domain
P Jemth, CM Johnson, S Gianni, AR Fersht
Protein Engineering Design and Selection
(2008)
21
The role of the turn in beta-hairpin formation during WW domain folding.
T Sharpe, AL Jonsson, TJ Rutherford, V Daggett, AR Fersht
Protein Sci
(2007)
16
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.
B Sot, SMV Freund, AR Fersht
Journal of Biological Chemistry
(2007)
282
Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex
H Tidow, R Melero, E Mylonas, SMV Freund, JG Grossmann, JM Carazo, DI Svergun, M Valle, AR Fersht
Proceedings of the National Academy of Sciences
(2007)
104
Correlation of Levels of Folded Recombinant p53 in Escherichia coli with Thermodynamic Stability in Vitro
S Mayer, S Rüdiger, HC Ang, AC Joerger, AR Fersht
Journal of molecular biology
(2007)
372
Searching for multiple folding pathways of a nearly symmetrical protein:: Temperature dependent Φ-Value analysis of the B domain of protein A
S Sato, AR Fersht
Journal of molecular biology
(2007)
372
The folding pathway of an FF domain: characterization of an on-pathway intermediate state under folding conditions by (15)N, (13)C(alpha) and (13)C-methyl relaxation dispersion and (1)H/(2)H-exchange NMR spectroscopy.
DM Korzhnev, TL Religa, P Lundström, AR Fersht, LE Kay
Journal of molecular biology
(2007)
372
The helix-turn-helix motif as an ultrafast independently folding domain:: The pathway of folding of Engrailed homeodomain
TL Religa, CM Johnson, DM Vu, SH Brewer, RB Dyer, AR Fersht
Proceedings of the National Academy of Sciences
(2007)
104
Solution Structure of ASPP2 N-terminal Domain (N-ASPP2) Reveals a Ubiquitin-like Fold
H Tidow, A Andreeva, TJ Rutherford, AR Fersht
J Mol Biol
(2007)
371
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.
DP Teufel, SM Freund, M Bycroft, AR Fersht
Proceedings of the National Academy of Sciences
(2007)
104
Structure–function–rescue: the diverse nature of common p53 cancer mutants
AC Joerger, AR Fersht
Oncogene
(2007)
26
Conformational entropy of alanine versus glycine in protein denatured states
KA Scott, DOV Alonso, S Sato, AR Fersht, V Daggett
Proc Natl Acad Sci U S A
(2007)
104
Structural biology: analysis of 'downhill' protein folding.
N Ferguson, TD Sharpe, CM Johnson, PJ Schartau, AR Fersht
Nature
(2007)
445
Folding and binding: implementing the game plan
AR Fersht, V Daggett
Current Opinion in Structural Biology
(2007)
17