Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

Ultraslow oligomerization equilibria of p53 and its implications.
E Natan, D Hirschberg, N Morgner, CV Robinson, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2009)
106
(doi: 10.1073/pnas.0907840106)
Effects of stability on the biological function of p53
KH Khoo, S Mayer, AR Fersht
Journal of Biological Chemistry
(2009)
284
(doi: 10.1074/jbc.M109.033183)
Adaptive Evolution of p53 Thermodynamic Stability
KH Khoo, A Andreeva, AR Fersht
J Mol Biol
(2009)
393
(doi: 10.1016/j.jmb.2009.08.013)
The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells
M Di Re, H Sembongi, J He, A Reyes, T Yasukawa, P Martinsson, LJ Bailey, S Goffart, JD Boyd-Kirkup, TS Wong, AR Fersht, JN Spelbrink, IJ Holt
Nucleic Acids Res
(2009)
37
(doi: 10.1093/nar/gkp614)
Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics
S Rajagopalan, A Andreeva, DP Teufel, SM Freund, AR Fersht
Journal of Biological Chemistry
(2009)
284
(doi: 10.1074/jbc.M109.006429)
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.
KH Khoo, AC Joerger, SMV Freund, AR Fersht
Protein engineering, design & selection : PEDS
(2009)
22
(doi: 10.1093/protein/gzp018)
The Folding Mechanism of BBL: Plasticity of Transition-State Structure Observed within an Ultrafast Folding Protein Family
H Neuweiler, TD Sharpe, TJ Rutherford, CM Johnson, MD Allen, N Ferguson, AR Fersht
Journal of molecular biology
(2009)
390
(doi: 10.1016/j.jmb.2009.05.011)
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain.
JMR Lambert, P Gorzov, DB Veprintsev, M Söderqvist, D Segerbäck, J Bergman, AR Fersht, P Hainaut, KG Wiman, VJN Bykov
Cancer Cell
(2009)
15
(doi: 10.1016/j.ccr.2009.03.003)
Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2
DP Teufel, M Bycroft, AR Fersht
Oncogene
(2009)
28
(doi: 10.1038/onc.2009.71)
Downhill versus Barrier-Limited Folding of BBL 1: Energetic and Structural Perturbation Effects upon Protonation of a Histidine of Unusually Low pKa
E Arbely, TJ Rutherford, TD Sharpe, N Ferguson, AR Fersht
Journal of Molecular Biology
(2009)
387
(doi: 10.1016/j.jmb.2008.12.055)
Corrigendum to "Conservation of Transition State Structure in Fast Folding Peripheral Subunit-Binding Domains" [J. Mol. Biol. 383 (2008) 224-237] (DOI:10.1016/j.jmb.2008.06.081)
TD Sharpe, N Ferguson, CM Johnson, AR Fersht
Journal of Molecular Biology
(2009)
387
(doi: 10.1016/j.jmb.2009.01.002)
Time-Resolved Fluorescence Resonance Energy Transfer Study Shows a Compact Denatured State of the B Domain of Protein A
F Huang, E Lerner, S Sato, D Amir, E Haas, AR Fersht
Biochemistry
(2009)
48
(doi: 10.1021/bi801890w)
Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers
J van Dieck, MR Fernandez-Fernandez, DB Veprintsev, AR Fersht
J Biol Chem
(2009)
284
(doi: 10.1074/jbc.M901351200)
Molecular basis of the interactions between the p73 N terminus and p300: Effects on transactivation and modulation by phosphorylation
S Burge, DP Teufel, FM Townsley, SMV Freund, M Bycroft, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2009)
106
(doi: 10.1073/pnas.0900383106)
Downhill versus Barrier-Limited Folding of BBL 3. Heterogeneity of the Native State of the BBL Peripheral Subunit Binding Domain and Its Implications for Folding Mechanisms
G Settanni, AR Fersht
Journal of molecular biology
(2009)
387
(doi: 10.1016/j.jmb.2009.02.014)
Solution Structure of the U11-48K CHHC Zinc-Finger Domain that Specifically Binds the 5′ Splice Site of U12-Type Introns
H Tidow, A Andreeva, TJ Rutherford, AR Fersht
Structure (London, England : 1993)
(2009)
17
(doi: 10.1016/j.str.2008.11.013)
Protein folding and binding: moving into unchartered territory.
V Daggett, AR Fersht
Curr Opin Struct Biol
(2009)
19
(doi: 10.1016/j.sbi.2009.01.006)
Sequence-Dependent Kinetics of One-Dimensional Diffusion of p53 on DNA
JS Leith, A Tafvizi, F Huang, AR Fersht, LA Mirny, AM van Oijen
Biophysical Journal
(2009)
96
(doi: 10.1016/j.bpj.2008.12.2125)
Single-molecule Studies Of p53 Sliding Along DNA
A Tafvizi, JS Leith, F Huang, AR Fersht, LA Mirny, AM van Oijen
Biophysical Journal
(2009)
96
(doi: 10.1016/j.bpj.2008.12.2128)
The novel p53 isoform "delta p53" is a misfolded protein and does not bind the p21 promoter site.
MM García-Alai, H Tidow, E Natan, FM Townsley, DB Veprintsev, AR Fersht
Protein science : a publication of the Protein Society
(2009)
17
(doi: 10.1110/ps.036996.108)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
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