Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution
DM Korzhnev, TL Religa, W Banachewicz, AR Fersht, LE Kay
Science (New York, N.Y.)
(2010)
329
(doi: 10.1126/science.1191723)
Refolding the engrailed homeodomain: structural basis for the accumulation of a folding intermediate.
ME McCully, DAC Beck, AR Fersht, V Daggett
Biophysical Journal
(2010)
99
(doi: 10.1016/j.bpj.2010.06.040)
The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces.
E Arbely, H Neuweiler, TD Sharpe, CM Johnson, AR Fersht
Protein science : a publication of the Protein Society
(2010)
19
(doi: 10.1002/pro.453)
Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant
L Briseño-Roa, Z Oliynyk, CM Timperley, AD Griffiths, AR Fersht
Protein Engineering Design and Selection
(2010)
24
(doi: 10.1093/protein/gzq046)
S100 proteins interact with the N-terminal domain of MDM2.
J van Dieck, JK Lum, DP Teufel, AR Fersht
FEBS Lett
(2010)
584
(doi: 10.1016/j.febslet.2010.06.024)
Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
S Rajagopalan, A Andreeva, TJ Rutherford, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2010)
107
(doi: 10.1073/pnas.1003689107)
Transdisciplinary EU science institute needs funds urgently.
JW Vasbinder, B Andersson, WB Arthur, M Boasson, R de Boer, JP Changeux, E Domingo, M Eigen, A Fersht, D Frenkel, M Rees, T Groen, R Huber, T Hunt, J Holland, R May, E Norrby, P Nijkamp, JM Lehn, R Rabbinge, M Scheffer, P Schuster, I Serageldin, J Stuip, J de Vries, W van Vierssen, R Willems
Nature
(2010)
463
(doi: 10.1038/463876a)
The Tumor Suppressor p53: From Structures to Drug Discovery
AC Joerger, AR Fersht
Cold Spring Harbor perspectives in biology
(2010)
2
(doi: 10.1101/cshperspect.a000919)
Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73.
J van Dieck, T Brandt, DP Teufel, DB Veprintsev, AC Joerger, AR Fersht
Oncogene
(2010)
29
(doi: 10.1038/onc.2009.490)
Engineering a two-helix bundle protein for folding studies.
CA Dodson, N Ferguson, TJ Rutherford, CM Johnson, AR Fersht
Protein Engineering Design and Selection
(2010)
23
(doi: 10.1093/protein/gzp080)
Toward the Rational Design of p53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant
N Basse, JL Kaar, G Settanni, AC Joerger, TJ Rutherford, AR Fersht
Chemistry & Biology
(2010)
17
(doi: 10.1016/j.chembiol.2009.12.011)
Reply to Campos et al.: Direct observation versus ambiguous kinetics and thermodynamics
F Huang, L Ying, H Neuweiler, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2009)
106
(doi: 10.1073/pnas.0913321107)
Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer.
F Huang, S Rajagopalan, G Settanni, RJ Marsh, DA Armoogum, N Nicolaou, AJ Bain, E Lerner, E Haas, L Ying, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2009)
106
(doi: 10.1073/pnas.0909644106)
Awakening guardian angels: Drugging the P53 pathway
CJ Brown, S Lain, CS Verma, AR Fersht, DP Lane
Nature Reviews Cancer
(2009)
9
(doi: 10.1038/nrc2763)
Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.
S Rajagopalan, RS Sade, FM Townsley, AR Fersht
Nucleic Acids Research
(2009)
38
(doi: 10.1093/nar/gkp1041)
Direct observation of ultrafast folding and denatured state dynamics in single protein molecules.
H Neuweiler, CM Johnson, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2009)
106
(doi: 10.1073/pnas.0910860106)
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
AC Joerger, S Rajagopalan, E Natan, DB Veprintsev, CV Robinson, AR Fersht
Proceedings of the National Academy of Sciences
(2009)
106
(doi: 10.1073/pnas.0905867106)
Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53.
J van Dieck, DP Teufel, AM Jaulent, MR Fernandez-Fernandez, TJ Rutherford, A Wyslouch-Cieszynska, AR Fersht
Journal of molecular biology
(2009)
394
(doi: 10.1016/j.jmb.2009.10.002)
Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer
F Huang, L Ying, AR Fersht
Proc Natl Acad Sci U S A
(2009)
106
(doi: 10.1073/pnas.0909126106)
Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53.
TS Wong, S Rajagopalan, SM Freund, TJ Rutherford, A Andreeva, FM Townsley, M Petrovich, AR Fersht
Nucleic Acids Research
(2009)
37
(doi: 10.1093/nar/gkp750)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
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