Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation.
A Nasedkin, M Marcellini, TL Religa, SM Freund, A Menzel, AR Fersht, P Jemth, D van der Spoel, J Davidsson
Plos One
(2015)
10
(doi: 10.1371/journal.pone.0125662)
Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis.
G Wang, AR Fersht
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1500243112)
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.
G Wang, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2015)
112
(doi: 10.1073/pnas.1500262112)
Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 nobel laureates in chemistry.
AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2013)
110
(doi: 10.1073/pnas.1320569110)
MDMX contains an autoinhibitory sequence element
M Bista, M Petrovich, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2013)
110
(doi: 10.1073/pnas.1317398110)
Small molecule induced reactivation of mutant p53 in cancer cells
X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, AR Fersht
Nucleic Acids Res
(2013)
41
(doi: 10.1093/nar/gkt305)
HEFLibs: Chemical probes for detecting halogen bonding in fragment-based lead discovery
R Wilcken, AC Joerger, AR Fersht, FM Boeckler
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245
Reply to Campos and Munoz: Why phosphate is a bad buffer for guanidinium chloride titrations
AR Fersht, M Petrovich
Proceedings of the National Academy of Sciences of the United States of America
(2013)
110
(doi: 10.1073/pnas.1303286110)
Denaturation (Proteins)
AR Fersht
(2013)
(doi: 10.1016/B978-0-12-374984-0.00393-4)
Don’t waste good methods on bad buffers and ambiguous data
F Huang, CM Johnson, M Petrovich, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2013)
110
(doi: 10.1073/pnas.1217840110)
3.1 Combining Simulation and Experiment to Map Protein Folding
AL Jonsson, AR Fersht, V Daggett
COMPREHENSIVE BIOPHYSICS, VOL 3: THE FOLDING OF PROTEINS AND NUCLEIC ACIDS
(2012)
3
(doi: 10.1016/b978-0-12-374920-8.00301-5)
Evaluating Drosophila p53 as a model system for studying cancer mutations.
G Herzog, AC Joerger, MD Shmueli, AR Fersht, E Gazit, D Segal
The Journal of biological chemistry
(2012)
287
(doi: 10.1074/jbc.m112.417980)
Chemical physics of protein folding.
PG Wolynes, WA Eaton, AR Fersht
Proceedings of the National Academy of Sciences
(2012)
109
(doi: 10.1073/pnas.1215733109)
Stability of p53 Homologs
T Brandt, JL Kaar, AR Fersht, DB Veprintsev
PloS one
(2012)
7
(doi: 10.1371/journal.pone.0047889)
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
SM Vogel, MR Bauer, AC Joerger, R Wilcken, T Brandt, DB Veprintsev, TJ Rutherford, AR Fersht, FM Boeckler
Proc Natl Acad Sci U S A
(2012)
109
(doi: 10.1073/pnas.1215060109)
Sequence-dependent sliding kinetics of p53
JS Leith, A Tafvizi, F Huang, WE Uspal, PS Doyle, AR Fersht, LA Mirny, AM van Oijen
Proceedings of the National Academy of Sciences
(2012)
109
(doi: 10.1073/pnas.1120452109)
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy
M Bista, SM Freund, AR Fersht
Proc Natl Acad Sci U S A
(2012)
109
(doi: 10.1073/pnas.1214176109)
In support of the BMRB.
JL Markley, H Akutsu, T Asakura, M Baldus, R Boelens, A Bonvin, R Kaptein, A Bax, I Bezsonova, MR Gryk, JC Hoch, DM Korzhnev, MW Maciejewski, D Case, WJ Chazin, TA Cross, S Dames, H Kessler, O Lange, T Madl, B Reif, M Sattler, D Eliezer, A Fersht, J Forman-Kay, LE Kay, J Fraser, J Gross, T Kortemme, A Sali, T Fujiwara, K Gardner, X Luo, J Rizo-Rey, M Rosen, RR Gil, C Ho, G Rule, AM Gronenborn, R Ishima, J Klein-Seetharaman, P Tang, P van der Wel, Y Xu, S Grzesiek, S Hiller, J Seelig, ED Laue, H Mott, D Nietlispach, I Barsukov, L-Y Lian, D Middleton, T Blumenschein, G Moore, I Campbell, J Schnell, IJ Vakonakis, A Watts, MR Conte, J Mason, M Pfuhl, MR Sanderson, J Craven, M Williamson, C Dominguez, G Roberts, U Günther, M Overduin, J Werner, P Williamson, C Blindauer, M Crump, P Driscoll, T Frenkiel, A Golovanov, S Matthews, J Parkinson, D Uhrin, M Williams, D Neuhaus, H Oschkinat, A Ramos, DE Shaw, C Steinbeck, M Vendruscolo, GW Vuister, KJ Walters, H Weinstein, K Wüthrich, S Yokoyama
Nat Struct Mol Biol
(2012)
19
(doi: 10.1038/nsmb.2371)
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition.
R Wilcken, G Wang, FM Boeckler, AR Fersht
Proc Natl Acad Sci U S A
(2012)
109
(doi: 10.1073/pnas.1211550109)
First-order rate-determining aggregation mechanism of p53 and its implications
G Wang, AR Fersht
Proc Natl Acad Sci U S A
(2012)
109
(doi: 10.1073/pnas.1211557109)
Yusuf Hamied Department of Chemistry
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