Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation
A Nasedkin, M Marcellini, TL Religa, SM Freund, A Menzel, AR Fersht, P Jemth, D van der Spoel, J Davidsson
Plos One
(2015)
10
(doi: 10.1371/journal.pone.0125662)
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.
G Wang, AR Fersht
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1500262112)
Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis
G Wang, AR Fersht
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1500243112)
Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 nobel laureates in chemistry.
AR Fersht
Proceedings of the National Academy of Sciences
(2013)
110
(doi: 10.1073/pnas.1320569110)
MDMX contains an autoinhibitory sequence element.
M Bista, M Petrovich, AR Fersht
Proceedings of the National Academy of Sciences
(2013)
110
(doi: 10.1073/pnas.1317398110)
Small molecule induced reactivation of mutant p53 in cancer cells
X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, AR Fersht
Nucleic Acids Research
(2013)
41
(doi: 10.1093/nar/gkt305)
HEFLibs: Chemical probes for detecting halogen bonding in fragment-based lead discovery
R Wilcken, AC Joerger, AR Fersht, FM Boeckler
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245
Reply to Campos and Munoz: Why phosphate is a bad buffer for guanidinium chloride titrations
AR Fersht, M Petrovich
Proceedings of the National Academy of Sciences
(2013)
110
(doi: 10.1073/pnas.1303286110)
Denaturation (Proteins)
AR Fersht
(2013)
(doi: 10.1016/B978-0-12-374984-0.00393-4)
Don’t waste good methods on bad buffers and ambiguous data
F Huang, CM Johnson, M Petrovich, AR Fersht
Proc Natl Acad Sci U S A
(2013)
110
(doi: 10.1073/pnas.1217840110)
3.1 Combining Simulation and Experiment to Map Protein Folding
AL Jonsson, AR Fersht, V Daggett
COMPREHENSIVE BIOPHYSICS, VOL 3: THE FOLDING OF PROTEINS AND NUCLEIC ACIDS
(2012)
3
(doi: 10.1016/b978-0-12-374920-8.00301-5)
Evaluating Drosophila p53 as a Model System for Studying Cancer Mutations
G Herzog, AC Joerger, MD Shmueli, AR Fersht, E Gazit, D Segal
Journal of Biological Chemistry
(2012)
287
(doi: 10.1074/jbc.m112.417980)
Chemical physics of protein folding
PG Wolynes, WA Eaton, AR Fersht
Proceedings of the National Academy of Sciences
(2012)
109
(doi: 10.1073/pnas.1215733109)
Stability of p53 Homologs
T Brandt, JL Kaar, AR Fersht, DB Veprintsev
PLoS ONE
(2012)
7
(doi: 10.1371/journal.pone.0047889)
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
SM Vogel, MR Bauer, AC Joerger, R Wilcken, T Brandt, DB Veprintsev, TJ Rutherford, AR Fersht, FM Boeckler
Proceedings of the National Academy of Sciences of the United States of America
(2012)
109
(doi: 10.1073/pnas.1215060109)
Sequence-dependent sliding kinetics of p53
JS Leith, A Tafvizi, F Huang, WE Uspal, PS Doyle, AR Fersht, LA Mirny, AM van Oijen
Proc Natl Acad Sci U S A
(2012)
109
(doi: 10.1073/pnas.1120452109)
Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.
M Bista, SM Freund, AR Fersht
Proceedings of the National Academy of Sciences
(2012)
109
(doi: 10.1073/pnas.1214176109)
In support of the BMRB.
JL Markley, H Akutsu, T Asakura, M Baldus, R Boelens, A Bonvin, R Kaptein, A Bax, I Bezsonova, MR Gryk, JC Hoch, DM Korzhnev, MW Maciejewski, D Case, WJ Chazin, TA Cross, S Dames, H Kessler, O Lange, T Madl, B Reif, M Sattler, D Eliezer, A Fersht, J Forman-Kay, LE Kay, J Fraser, J Gross, T Kortemme, A Sali, T Fujiwara, K Gardner, X Luo, J Rizo-Rey, M Rosen, RR Gil, C Ho, G Rule, AM Gronenborn, R Ishima, J Klein-Seetharaman, P Tang, P van der Wel, Y Xu, S Grzesiek, S Hiller, J Seelig, ED Laue, H Mott, D Nietlispach, I Barsukov, L-Y Lian, D Middleton, T Blumenschein, G Moore, I Campbell, J Schnell, IJ Vakonakis, A Watts, MR Conte, J Mason, M Pfuhl, MR Sanderson, J Craven, M Williamson, C Dominguez, G Roberts, U Günther, M Overduin, J Werner, P Williamson, C Blindauer, M Crump, P Driscoll, T Frenkiel, A Golovanov, S Matthews, J Parkinson, D Uhrin, M Williams, D Neuhaus, H Oschkinat, A Ramos, DE Shaw, C Steinbeck, M Vendruscolo, GW Vuister, KJ Walters, H Weinstein, K Wüthrich, S Yokoyama
Nature Structural & Molecular Biology
(2012)
19
(doi: 10.1038/nsmb.2371)
First-order rate-determining aggregation mechanism of p53 and its implications
G Wang, AR Fersht
Proc Natl Acad Sci U S A
(2012)
109
(doi: 10.1073/pnas.1211557109)
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition
R Wilcken, G Wang, FM Boeckler, AR Fersht
Proceedings of the National Academy of Sciences
(2012)
109
(doi: 10.1073/pnas.1211550109)
Yusuf Hamied Department of Chemistry
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