Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

Helix stability in barstar peptides.
AS Soler-González, AR Fersht
European journal of biochemistry
(2004)
249
(doi: 10.1111/j.1432-1033.1997.t01-1-00724.x)
Carl-Ivar!Branden - 1934-2004 - Obituary
S Zhang, A Rich, JL Sussman, AR Fersht
Nature Structural & Molecular Biology
(2004)
11
(doi: 10.1038/nsmb0604-490)
Phi-value analysis and the nature of protein-folding transition states.
AR Fersht, S Sato
Proc Natl Acad Sci U S A
(2004)
101
(doi: 10.1073/pnas.0402684101)
Designing a metal-binding site in the scaffold of Escherichia coli KDO8PS
Z Oliynyk, L Briseño-Roa, T Janowitz, P Sondergeld, AR Fersht
Protein Eng Des Sel
(2004)
17
(doi: 10.1093/protein/gzh046)
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation.
P Jemth, S Gianni, R Day, B Li, CM Johnson, V Daggett, AR Fersht
Proceedings of the National Academy of Sciences
(2004)
101
(doi: 10.1073/pnas.0401732101)
Testing protein-folding simulations by experiment: B domain of protein A.
S Sato, TL Religa, V Daggett, AR Fersht
Proceedings of the National Academy of Sciences of the United States of America
(2004)
101
(doi: 10.1073/pnas.0401396101)
The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid
T Batuwangala, D Shepherd, SD Gadola, KJC Gibson, NR Zaccai, AR Fersht, GS Besra, V Cerundolo, EY Jones
The Journal of Immunology
(2004)
172
(doi: 10.4049/jimmunol.172.4.2382)
Structural Distortion of p53 by the Mutation R249S and its Rescue by a Designed Peptide: Implications for “Mutant Conformation”
A Friedler, BS DeDecker, SMV Freund, C Blair, S Rüdiger, AR Fersht
J Mol Biol
(2004)
336
(doi: 10.1016/j.jmb.2003.12.005)
Binding of p53-derived Ligands to MDM2 Induces a Variety of Long Range Conformational Changes
O Schon, A Friedler, S Freund, AR Fersht
J Mol Biol
(2004)
336
(doi: 10.1016/j.jmb.2003.11.051)
Analysis of Enzyme Structure and Activity by Protein Engineering
AR Fersht, J Shi, AJ Wilkinson, DM Blow, P Carter, MMY Waye, GP Winter
Angewandte Chemie International Edition in English
(2003)
23
(doi: 10.1002/anie.198404673)
Structural insights in the folding of small single-domain proteins.
S Gianni, U Mayor, AR Fersht
The Italian Journal of Biochemistry
(2003)
52
The Denatured State of Engrailed Homeodomain under Denaturing and Native Conditions
U Mayor, JG Grossmann, NW Foster, SMV Freund, AR Fersht
Journal of molecular biology
(2003)
333
(doi: 10.1016/j.jmb.2003.08.062)
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide.
N Issaeva, A Friedler, P Bozko, KG Wiman, AR Fersht, G Selivanova
Proceedings of the National Academy of Sciences
(2003)
100
(doi: 10.1073/pnas.1835733100)
Unifying features in protein-folding mechanisms
S Gianni, NR Guydosh, F Khan, TD Caldas, U Mayor, GWN White, ML DeMarco, V Daggett, AR Fersht
Proc Natl Acad Sci U S A
(2003)
100
(doi: 10.1073/pnas.1835776100)
The Kinetic Pathway of Folding of Barnase
F Khan, JI Chuang, S Gianni, AR Fersht
Journal of molecular biology
(2003)
333
(doi: 10.1016/j.jmb.2003.08.024)
Crystal Structure of a Superstable Mutant of Human p53 Core Domain INSIGHTS INTO THE MECHANISM OF RESCUING ONCOGENIC MUTATIONS*
AC Joerger, MD Allen, AR Fersht
The Journal of biological chemistry
(2003)
279
(doi: 10.1074/jbc.M309732200)
Crystal structures of engrailed homeodomain mutants - Implications for stability and dynamics
EJ Stollar, U Mayor, SC Lovell, L Federici, SMV Freund, AR Fersht, BF Luisi
The Journal of biological chemistry
(2003)
278
(doi: 10.1074/jbc.M308029200)
Rapid amyloid fiber formation from the fast-folding WW domain FBP28.
N Ferguson, J Berriman, M Petrovich, TD Sharpe, JT Finch, AR Fersht
Proc Natl Acad Sci U S A
(2003)
100
(doi: 10.1073/pnas.1333907100)
Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity
AC Joerger, S Mayer, AR Fersht
Proceedings of the National Academy of Sciences
(2003)
100
(doi: 10.1073/pnas.0531477100)
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules.
A Friedler, DB Veprintsev, LO Hansson, AR Fersht
Journal of Biological Chemistry
(2003)
278
(doi: 10.1074/jbc.m302458200)
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
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