Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relationships.
Biochemistry
(2002)
12
1067
(doi: 10.1021/bi00730a008)
Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin
Biochemistry
(2002)
12
2025
(doi: 10.1021/bi00735a001)
Demonstration of two active sites on a monomeric aminoacyl-tRNA synthetase. Possible roles of negative cooperativity and half-of-the-sites reactivity in oligomeric enzymes.
Biochemistry
(2002)
14
5
(doi: 10.1021/bi00672a002)
Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. Stereochemical interpretation
Biochemistry
(2002)
12
2035
(doi: 10.1021/bi00735a002)
Mechanism of the -chymotrypsin-catalyzed hydrolysis of specific amide substrates.
Journal of the American Chemical Society
(2002)
94
293
(doi: 10.1021/ja00756a061)
Ligand binding stoichiometries, subunit structure, and slow transitions in aminoacyl-tRNA synthetases
Biochemistry
(2002)
16
4005
(doi: 10.1021/bi00637a011)
Anomalous pH dependence of Kcat/Km in enzyme reactions. Rate constants for the association of chymotrypsin with substrates
Biochemistry
(2002)
12
4713
(doi: 10.1021/bi00747a026)
Mechanism of the -chymotrypsin-catalyzed hydrolysis of amides. pH dependence of k c and K m . Kinetic detection of an intermediate.
J Am Chem Soc
(2002)
93
7079
(doi: 10.1021/ja00754a066)
Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and half-of-the-sites reactivity in aminoacylation
Biochemistry
(2002)
14
3344
(doi: 10.1021/bi00686a009)
Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing.
Biochemistry
(2002)
15
3342
(doi: 10.1021/bi00660a026)
Mechanism of aminoacylation of transfer RNA. A pre-steady-state analysis of the reaction pathway catalyzed by the methionyl-tRNA synthetase of Bacillus stearothermophilus
Biochemistry
(2002)
17
5591
(doi: 10.1021/bi00619a002)
pH Dependence of chymotrypsin catalysis. Appendix. Substrate binding to dimeric α-chymotrypsin studied by x-ray diffraction and the equilibrium method
Biochemistry
(2002)
13
1416
(doi: 10.1021/bi00704a016)
Evidence for the double-sieve editing mechanism in protein synthesis. Steric exclusion of isoleucine by valyl-tRNA synthetases
Biochemistry
(2002)
18
2627
(doi: 10.1021/bi00579a030)
Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases
Biochemistry
(2002)
14
1
(doi: 10.1021/bi00672a001)
Energetics of complementary side chain packing in a protein hydrophobic core
Biochemistry
(2002)
28
4914
(doi: 10.1021/bi00437a058)
Protection of an unstable reaction intermediate examined with linear free energy relationships in tyrosyl-tRNA synthetase
Biochemistry
(2002)
28
9201
(doi: 10.1021/bi00449a036)
Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin.
Biochemistry
(2002)
13
2174
(doi: 10.1021/bi00707a027)
Acyl-transfer reactions of amides and esters with alcohols and thiols. A reference system for the serine and cysteine proteinases. Concerning the N protonation of amides and amide-imidate equilibria.
J Am Chem Soc
(2002)
93
3504
(doi: 10.1021/ja00743a035)
Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles
Biochemistry
(2002)
29
9343
(doi: 10.1021/bi00492a006)
Ligand binding and enzymic catalysis coupled through subunits in tyrosyl-tRNA synthetase
Biochemistry
(2002)
14
13
(doi: 10.1021/bi00672a003)
