skip to content
Home

Yusuf Hamied Department of Chemistry

 

Publications by Professor Andreas Bender

Novel benzoxazine-based aglycones block glucose uptake in vivo by inhibiting glycosidases.
H Bharathkumar, MS Sundaram, S Jagadish, S Paricharak, M Hemshekhar, D Mason, K Kemparaju, KS Girish, Basappa, A Bender, KS Rangappa
– Plos One
(2014)
9,
e102759
(DOI: 10.1371/journal.pone.0102759)
Proteochemometric modeling in a Bayesian framework
I Cortes-Ciriano, GJ van Westen, EB Lenselink, DS Murrell, A Bender, T Malliavin
– Journal of Cheminformatics
(2014)
6,
35
(DOI: 10.1186/1758-2946-6-35)
In Silico Target Predictions: Defining a Benchmarking Data Set and Comparison of Performance of the Multiclass Naive Bayes and Parzen-Rosenblatt Window (vol 53, pg 1957, 2013)
A Koutsoukas, R Lowe, Y KalantarMotamedi, HY Mussa, W Klaffke, JB Mitchell, RC Glen, A Bender
– Journal of chemical information and modeling
(2014)
54,
2180
(DOI: 10.1021/ci500255v)
A community effort to assess and improve drug sensitivity prediction algorithms
JC Costello, LM Heiser, E Georgii, M Gönen, MP Menden, NJ Wang, M Bansal, M Ammad-ud-din, P Hintsanen, SA Khan, J-P Mpindi, O Kallioniemi, A Honkela, T Aittokallio, K Wennerberg, NCI DREAM Community, JJ Collins, D Gallahan, D Singer, J Saez-Rodriguez, S Kaski, JW Gray, G Stolovitzky
– Nature biotechnology
(2014)
32,
1202
(DOI: 10.1038/nbt.2877)
Towards predictive resistance models for agrochemicals by combining chemical and protein similarity via proteochemometric modelling.
GJP van Westen, A Bender, JP Overington
– Journal of Chemical Biology
(2014)
7,
119
(DOI: 10.1007/s12154-014-0112-2)
Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126.
SA Hudson, EH Mashalidis, A Bender, KJ McLean, AW Munro, C Abell
– Chembiochem
(2014)
15,
549
(DOI: 10.1002/cbic.201300697)
Synthesis and biological evaluation of tetrahydropyridinepyrazoles ('PFPs') as inhibitors of STAT3 phosphorylation
CN Revanna, Basappa, V Srinivasa, F Li, KS Siveen, X Dai, SN Swamy, DG Bhadregowda, G Sethi, K Mantelingu, A Bender, K Rangappa
– Medchemcomm
(2014)
5,
32
(DOI: 10.1039/c3md00119a)
Synthesis, biological evaluation and <i>in silico</i> and <i>in vitro</i> mode-of-action analysis of novel dihydropyrimidones targeting PPAR-γ
H Bharathkumar, S Paricharak, KR Dinesh, KS Siveen, JE Fuchs, S Rangappa, CD Mohan, N Mohandas, AP Kumar, G Sethi, A Bender, B Basappa, KS Rangappa
– Rsc Advances
(2014)
4,
45143
(DOI: 10.1039/c4ra08713e)
Comparative mode-of-action analysis following manual and automated phenotype detection in Xenopus laevis
G Drakakis, AE Hendry, K Hanson, SC Brewerton, MJ Bodkin, DA Evans, GN Wheeler, A Bender
– RSC Medicinal Chemistry
(2014)
5,
386
(DOI: 10.1039/c3md00313b)
Modelling ligand selectivity of serine proteases using integrative proteochemometric approaches improves model performance and allows the multi-target dependent interpretation of features
QU Ain, O Méndez-Lucio, IC Ciriano, T Malliavin, GJP van Westen, A Bender
– Integrative biology : quantitative biosciences from nano to macro
(2014)
6,
1023
(DOI: 10.1039/c4ib00175c)
Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases
S Paricharak, T Klenka, M Augustin, UA Patel, A Bender
– Journal of Cheminformatics
(2013)
5,
49
(DOI: 10.1186/1758-2946-5-49)
How diverse are diversity assessment methods? A comparative analysis and benchmarking of molecular descriptor space.
A Koutsoukas, S Paricharak, WRJD Galloway, DR Spring, AP Ijzerman, RC Glen, D Marcus, A Bender
– J. Chem. Inf. Model.
(2013)
54,
230
(DOI: 10.1021/ci400469u)
Design, synthesis and biological evaluation of a novel allosteric inhibitor of HSET that damages cancer cells with supernumerary centrosomes.
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
– Molecular Cancer Therapeutics
(2013)
12,
B96
(DOI: 10.1158/1535-7163.TARG-13-B96)
Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.
CA Watts, FM Richards, A Bender, PJ Bond, O Korb, O Kern, M Riddick, P Owen, RM Myers, J Raff, F Gergely, DI Jodrell, SV Ley
– Chem Biol
(2013)
20,
1399
(DOI: 10.1016/j.chembiol.2013.09.012)
Experimental Confirmation of New Drug-Target Interactions Predicted by Drug Profile Matching
L Végner, Á Peragovics, L Tombor, B Jelinek, P Czobor, A Bender, Z Simon, A Málnási-Csizmadia
– Journal of medicinal chemistry
(2013)
56,
8377
(DOI: 10.1021/jm400813y)
Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to <i>Xenopus laevis</i> Phenotypic Readouts
S Liggi, G Drakakis, AE Hendry, KM Hanson, SC Brewerton, GN Wheeler, MJ Bodkin, DA Evans, A Bender
– Molecular informatics
(2013)
32,
1009
(DOI: 10.1002/minf.201300102)
Benchmarking of protein descriptor sets in proteochemometric modeling (part 2): modeling performance of 13 amino acid descriptor sets
GJ van Westen, RF Swier, I Cortes-Ciriano, JK Wegner, JP Overington, AP Ijzerman, HW van Vlijmen, A Bender
– J Cheminform
(2013)
5,
42
(DOI: 10.1186/1758-2946-5-42)
Benchmarking of protein descriptor sets in proteochemometric modeling (part 1): comparative study of 13 amino acid descriptor sets
GJ van Westen, RF Swier, JK Wegner, AP Ijzerman, HW van Vlijmen, A Bender
– J Cheminform
(2013)
5,
42
(DOI: 10.1186/1758-2946-5-41)
Diversity Selection of Compounds Based on 'Protein Affinity Fingerprints' Improves Sampling of <i>Bioactive</i> Chemical Space
HP Nguyen, A Koutsoukas, F Mohd Fauzi, G Drakakis, M Maciejewski, RC Glen, A Bender
– Chemical Biology & Drug Design
(2013)
82,
252
(DOI: 10.1111/cbdd.12155)
In silico target predictions: defining a benchmarking data set and comparison of performance of the multiclass Naïve Bayes and Parzen-Rosenblatt window.
A Koutsoukas, R Lowe, Y Kalantarmotamedi, HY Mussa, W Klaffke, JBO Mitchell, RC Glen, A Bender
– Journal of chemical information and modeling
(2013)
53,
1957
(DOI: 10.1021/ci300435j)

    Study at Cambridge

    About the University

    Research at Cambridge