An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions
G Cereghetti, VM Kissling, LM Koch, A Arm, CC Schmidt, Y Thüringer, N Zamboni, P Afanasyev, M Linsenmeier, C Eichmann, S Kroschwald, J Zhou, Y Cao, DM Pfizenmaier, T Wiegand, R Cadalbert, G Gupta, D Boehringer, TPJ Knowles, R Mezzenga, P Arosio, R Riek, M Peter
– Developmental Cell
(2024)
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Biomolecular condensates sustain pH gradients at equilibrium through charge neutralisation
H Ausserwöger, R Scrutton, C Fischer, T Sneideris, D Qian, E de Csilléry, I Baronaite, K Saar, A Białek, M Oeller, G Krainer, T Franzmann, S Wittmann, J Iglesias-Artola, G Invernizzi, A Hyman, S Alberti, N Lorenzen, T Knowles
(2024)
Solutes unmask differences in clustering versus phase separation of FET proteins.
M Kar, LT Vogel, G Chauhan, S Felekyan, H Ausserwöger, TJ Welsh, F Dar, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
– Nat Commun
(2024)
15,
Polysaccharide functionalization reduces lipid vesicle stiffness
K Jahnke, M Pavlovic, W Xu, A Chen, TPJ Knowles, LR Arriaga, DA Weitz
– Proceedings of the National Academy of Sciences of the United States of America
(2024)
121,
Kinetic models reveal the interplay of protein production and aggregation.
J Wei, G Meisl, A Dear, M Oosterhuis, R Melki, C Emanuelsson, S Linse, TPJ Knowles
– Chemical science
(2024)
15,
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
– Nat Commun
(2024)
15,
Maximum entropy determination of mammalian proteome dynamics.
AJ Dear, GA Garcia, G Meisl, GA Collins, TPJ Knowles, AL Goldberg
– Proceedings of the National Academy of Sciences
(2024)
121,
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
– Chem Sci
(2024)
15,
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TL Chris Ng, M Hoare, J Maristany, E Wilde, T Sneideris, J Huertas, B Agbetiameh, M Furukawa, J Joseph, TPJ Knowles, R Collepardo-Guevara, L Itzhaki, J Kumita
(2024)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
– Nat Chem Biol
(2024)
20,
